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Trmt61a tRNA methyltransferase 61A [ Mus musculus (house mouse) ]

Gene ID: 328162, updated on 11-Apr-2024

Summary

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Official Symbol
Trmt61aprovided by MGI
Official Full Name
tRNA methyltransferase 61Aprovided by MGI
Primary source
MGI:MGI:2443487
See related
Ensembl:ENSMUSG00000060950 AllianceGenome:MGI:2443487
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gcd14; Trm61; 6720458F09Rik
Summary
Predicted to enable mRNA (adenine-N1-)-methyltransferase activity. Predicted to be involved in mRNA methylation and tRNA methylation. Predicted to act upstream of or within methylation and tRNA processing. Predicted to be part of tRNA (m1A) methyltransferase complex. Predicted to be active in nucleus. Orthologous to human TRMT61A (tRNA methyltransferase 61A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 16.2), adrenal adult (RPKM 12.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
12 F1; 12 61.09 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (111644539..111650336)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (111678105..111683902)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7187 Neighboring gene MAP/microtubule affinity regulating kinase 3 Neighboring gene STARR-positive B cell enhancer ABC_E10775 Neighboring gene creatine kinase, brain Neighboring gene VISTA enhancer mm1606 Neighboring gene predicted gene, 51961 Neighboring gene predicted gene, 36635

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. tRNA-m(1)A modification promotes T cell expansion via efficient MYC protein synthesis. Liu Y, et al. Nat Immunol, 2022 Oct. PMID 36138184
  2. The bipartite structure of the tRNA m1A58 methyltransferase from S. cerevisiae is conserved in humans. Ozanick S, et al. RNA, 2005 Aug. PMID 16043508, Free PMC Article
  3. New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules. Das R, et al. J Cell Sci, 2019 Jun 17. PMID 31138677, Free PMC Article
  4. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
  5. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. tRNA-m[1]A modification promotes T cell expansion via efficient MYC protein synthesis.
    Title: tRNA-m(1)A modification promotes T cell expansion via efficient MYC protein synthesis.
  2. Shows conservation of the yeast TRM61 (GCD14) protein in mouse, human and Drosophila, and demonstrates functional activity of the human ortholog.
    Title: The bipartite structure of the tRNA m1A58 methyltransferase from S. cerevisiae is conserved in humans.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables mRNA (adenine-N1-)-methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables tRNA (adenine(58)-N1)-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA methylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tRNA methylation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within tRNA processing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of tRNA (m1A) methyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of tRNA (m1A) methyltransferase complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A
Names
mRNA methyladenosine-N(1)-methyltransferase catalytic subunit TRMT61A
tRNA (adenine-N(1)-)-methyltransferase catalytic subunit TRM61
tRNA (adenine-N(1)-)-methyltransferase catalytic subunit TRMT61A
tRNA methyltransferase 61 homolog A
tRNA(m1A58)-methyltransferase subunit TRM61
tRNA(m1A58)-methyltransferase subunit TRMT61A
tRNA(m1A58)MTase subunit TRM61
tRNA(m1A58)MTase subunit TRMT61A
NP_001093262.1
NP_001093263.1
NP_796348.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001099792.1 → NP_001093262.1  tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A

    See identical proteins and their annotated locations for NP_001093262.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AI447734, BC051186, BY122337, BY345591
    Consensus CDS
    CCDS26184.1
    UniProtKB/Swiss-Prot
    Q80XC2, Q8BMD4, Q8BX33
    Related
    ENSMUSP00000133128.2, ENSMUST00000168338.2
    Conserved Domains (3) summary
    COG2519
    Location:9 → 290
    Gcd14; tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]
    pfam08704
    Location:64 → 287
    GCD14; tRNA methyltransferase complex GCD14 subunit
    pfam14801
    Location:12 → 58
    GCD14_N; tRNA methyltransferase complex GCD14 subunit N-term

  2. NM_001099793.1 → NP_001093263.1  tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A

    See identical proteins and their annotated locations for NP_001093263.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AI447734, BB868135, BC051186
    Consensus CDS
    CCDS26184.1
    UniProtKB/Swiss-Prot
    Q80XC2, Q8BMD4, Q8BX33
    Conserved Domains (3) summary
    COG2519
    Location:9 → 290
    Gcd14; tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]
    pfam08704
    Location:64 → 287
    GCD14; tRNA methyltransferase complex GCD14 subunit
    pfam14801
    Location:12 → 58
    GCD14_N; tRNA methyltransferase complex GCD14 subunit N-term

  3. NM_177374.4 → NP_796348.2  tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A

    See identical proteins and their annotated locations for NP_796348.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AI447734, BC051186, BY122337
    Consensus CDS
    CCDS26184.1
    UniProtKB/Swiss-Prot
    Q80XC2, Q8BMD4, Q8BX33
    Related
    ENSMUSP00000082011.4, ENSMUST00000084947.10
    Conserved Domains (3) summary
    COG2519
    Location:9 → 290
    Gcd14; tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]
    pfam08704
    Location:64 → 287
    GCD14; tRNA methyltransferase complex GCD14 subunit
    pfam14801
    Location:12 → 58
    GCD14_N; tRNA methyltransferase complex GCD14 subunit N-term

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    111644539..111650336
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80XC2.1 GenPept UniProtKB/Swiss-Prot:Q80XC2

Gene LinkOut

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