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Togaram1 TOG array regulator of axonemal microtubules 1 [ Mus musculus (house mouse) ]

Gene ID: 328108, updated on 5-Mar-2024

Summary

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Official Symbol
Togaram1provided by MGI
Official Full Name
TOG array regulator of axonemal microtubules 1provided by MGI
Primary source
MGI:MGI:2684313
See related
Ensembl:ENSMUSG00000035614 AllianceGenome:MGI:2684313
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fam179b; C130034K06; A430041B07Rik
Summary
Predicted to enable microtubule binding activity. Involved in positive regulation of microtubule polymerization. Located in ciliary basal body. Colocalizes with microtubule. Human ortholog(s) of this gene implicated in Joubert syndrome. Orthologous to human TOGARAM1 (TOG array regulator of axonemal microtubules 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 5.8), frontal lobe adult (RPKM 3.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
12 C1; 12 27.21 cM
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (65012350..65069347)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (64965576..65022573)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein L7A, pseudogene 1 Neighboring gene STARR-seq mESC enhancer starr_32310 Neighboring gene STARR-positive B cell enhancer mm9_chr12:66018613-66018914 Neighboring gene predicted gene, 51965 Neighboring gene predicted gene 527 Neighboring gene kelch-like 28 Neighboring gene STARR-seq mESC enhancer starr_32311 Neighboring gene STARR-positive B cell enhancer ABC_E7138 Neighboring gene predicted gene, 51966 Neighboring gene STARR-seq mESC enhancer starr_32313 Neighboring gene pre-mRNA processing factor 39 Neighboring gene predicted gene, 25970

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Conditional knockout of TOG results in CNS hypomyelination. Maggipinto MJ, et al. Glia, 2017 Mar. PMID 28063167, Free PMC Article
  2. Crescerin uses a TOG domain array to regulate microtubules in the primary cilium. Das A, et al. Mol Biol Cell, 2015 Nov 15. PMID 26378256, Free PMC Article
  3. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895
  4. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
  5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0423, MGC189816, MGC189944, mKIAA0423

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell projection organization IEA
Inferred from Electronic Annotation
more info
  
involved_in cilium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of microtubule polymerization IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in axoneme ISO
Inferred from Sequence Orthology
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in ciliary basal body IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cilium IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cilium IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasmic microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
colocalizes_with microtubule IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
TOG array regulator of axonemal microtubules protein 1
Names
crescerin-1
family with sequence similarity 179, member B
protein FAM179B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001364325.1 → NP_001351254.1  TOG array regulator of axonemal microtubules protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC159621, AC159632
    Consensus CDS
    CCDS88345.1
    UniProtKB/TrEMBL
    A0A1Y7VLS3, B2RXW9
    Related
    ENSMUSP00000152616.2, ENSMUST00000223166.2
    Conserved Domains (2) summary
    sd00044
    Location:395 → 419
    HEAT; HEAT repeat [structural motif]
    pfam15402
    Location:789 → 905
    Spc7_N; N-terminus of kinetochore NMS complex subunit Spc7

  2. NM_177805.3 → NP_808473.2  TOG array regulator of axonemal microtubules protein 1 isoform 2

    See identical proteins and their annotated locations for NP_808473.2

    Status: VALIDATED

    Source sequence(s)
    AC159621, AC159632
    Consensus CDS
    CCDS49075.1
    UniProtKB/Swiss-Prot
    F8WJB2, Q6A070
    UniProtKB/TrEMBL
    B2RXS2, B7ZWL4
    Related
    ENSMUSP00000070382.8, ENSMUST00000066296.9
    Conserved Domains (2) summary
    pfam08192
    Location:957 → 1108
    Peptidase_S64; Peptidase family S64
    sd00044
    Location:395 → 419
    HEAT; HEAT repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    65012350..65069347
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006516020.4 → XP_006516083.1  TOG array regulator of axonemal microtubules protein 1 isoform X1

    UniProtKB/TrEMBL
    B2RXW9
    Conserved Domains (2) summary
    sd00044
    Location:395 → 419
    HEAT; HEAT repeat [structural motif]
    pfam15402
    Location:799 → 915
    Spc7_N; N-terminus of kinetochore NMS complex subunit Spc7

  2. XM_006516022.4 → XP_006516085.1  TOG array regulator of axonemal microtubules protein 1 isoform X2

    UniProtKB/TrEMBL
    B2RXS2, B7ZWL4
    Conserved Domains (2) summary
    sd00044
    Location:395 → 419
    HEAT; HEAT repeat [structural motif]
    pfam15402
    Location:799 → 915
    Spc7_N; N-terminus of kinetochore NMS complex subunit Spc7

  3. XM_036157506.1 → XP_036013399.1  TOG array regulator of axonemal microtubules protein 1 isoform X3

    UniProtKB/TrEMBL
    B2RXW9
    Conserved Domains (2) summary
    sd00044
    Location:395 → 419
    HEAT; HEAT repeat [structural motif]
    pfam15402
    Location:799 → 915
    Spc7_N; N-terminus of kinetochore NMS complex subunit Spc7

  4. XM_006516023.4 → XP_006516086.1  TOG array regulator of axonemal microtubules protein 1 isoform X4

    UniProtKB/TrEMBL
    B2RXW9
    Conserved Domains (2) summary
    sd00044
    Location:395 → 419
    HEAT; HEAT repeat [structural motif]
    pfam15402
    Location:799 → 915
    Spc7_N; N-terminus of kinetochore NMS complex subunit Spc7

  5. XM_017315119.2 → XP_017170608.1  TOG array regulator of axonemal microtubules protein 1 isoform X5

    Conserved Domains (2) summary
    sd00044
    Location:395 → 419
    HEAT; HEAT repeat [structural motif]
    pfam15402
    Location:799 → 915
    Spc7_N; N-terminus of kinetochore NMS complex subunit Spc7

RNA

  1. XR_004937521.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6A070.3 GenPept UniProtKB/Swiss-Prot:Q6A070

Gene LinkOut

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