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Slfn5 schlafen 5 [ Mus musculus (house mouse) ]

Gene ID: 327978, updated on 27-Feb-2024

Summary

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Official Symbol
Slfn5provided by MGI
Official Full Name
schlafen 5provided by MGI
Primary source
MGI:MGI:1329004
See related
Ensembl:ENSMUSG00000054404 AllianceGenome:MGI:1329004
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable ATP binding activity. Predicted to act upstream of or within cell differentiation. Located in nucleus. Orthologous to human SLFN5 (schlafen family member 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in subcutaneous fat pad adult (RPKM 9.0), heart adult (RPKM 7.4) and 19 other tissues See more
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Genomic context

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Location:
11 C; 11 50.3 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (82842175..82855681)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (82951349..82964850)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene notchless homolog 1 Neighboring gene unc-45 myosin chaperone B Neighboring gene unc-45 myosin chaperone B, opposite strand Neighboring gene schlafen 5, opposite strand Neighboring gene SET domain-containing protein 8 pseudogene Neighboring gene schlafen 9 Neighboring gene microRNA 7679

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Schlafen-8 is essential for lymphatic endothelial cell activation in experimental autoimmune encephalomyelitis. Nakagawa K, et al. Int Immunol, 2018 Mar 8. PMID 29528433
  2. Expression and regulatory effects of murine Schlafen (Slfn) genes in malignant melanoma and renal cell carcinoma. Mavrommatis E, et al. J Biol Chem, 2013 Nov 15. PMID 24089532, Free PMC Article
  3. Modulation of T cell development and activation by novel members of the Schlafen (slfn) gene family harbouring an RNA helicase-like motif. Geserick P, et al. Int Immunol, 2004 Oct. PMID 15351786
  4. Subcellular localization of the Schlafen protein family. Neumann B, et al. Biochem Biophys Res Commun, 2008 May 23. PMID 18355440
  5. Evolution of the Schlafen genes, a gene family associated with embryonic lethality, meiotic drive, immune processes and orthopoxvirus virulence. Bustos O, et al. Gene, 2009 Nov 1. PMID 19619625, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (6) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
schlafen family member 5
Names
expressesd sequence AI956840

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_183201.4 → NP_899024.3  schlafen family member 5

    See identical proteins and their annotated locations for NP_899024.3

    Status: VALIDATED

    Source sequence(s)
    AK036486, AK040359, AL603745
    Consensus CDS
    CCDS25153.1
    UniProtKB/Swiss-Prot
    Q148Z1, Q3V3H0, Q5QNT5, Q7TMA8, Q8CBA2
    UniProtKB/TrEMBL
    A0A1G5SK44
    Related
    ENSMUSP00000064819.3, ENSMUST00000067443.10
    Conserved Domains (3) summary
    PHA02782
    Location:43 → 328
    PHA02782; hypothetical protein; Provisional
    pfam09848
    Location:571 → 759
    DUF2075; Uncharacterized conserved protein (DUF2075)
    cl28899
    Location:571 → 645
    DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    82842175..82855681
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006533574.4 → XP_006533637.1  schlafen family member 5 isoform X1

    See identical proteins and their annotated locations for XP_006533637.1

    UniProtKB/Swiss-Prot
    Q148Z1, Q3V3H0, Q5QNT5, Q7TMA8, Q8CBA2
    UniProtKB/TrEMBL
    A0A1G5SK44
    Conserved Domains (3) summary
    PHA02782
    Location:43 → 328
    PHA02782; hypothetical protein; Provisional
    pfam09848
    Location:571 → 759
    DUF2075; Uncharacterized conserved protein (DUF2075)
    cl28899
    Location:571 → 645
    DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily

  2. XM_006533580.3 → XP_006533643.1  schlafen family member 5 isoform X1

    See identical proteins and their annotated locations for XP_006533643.1

    UniProtKB/Swiss-Prot
    Q148Z1, Q3V3H0, Q5QNT5, Q7TMA8, Q8CBA2
    UniProtKB/TrEMBL
    A0A1G5SK44
    Conserved Domains (3) summary
    PHA02782
    Location:43 → 328
    PHA02782; hypothetical protein; Provisional
    pfam09848
    Location:571 → 759
    DUF2075; Uncharacterized conserved protein (DUF2075)
    cl28899
    Location:571 → 645
    DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily

  3. XM_017314617.3 → XP_017170106.1  schlafen family member 5 isoform X1

    UniProtKB/Swiss-Prot
    Q148Z1, Q3V3H0, Q5QNT5, Q7TMA8, Q8CBA2
    UniProtKB/TrEMBL
    A0A1G5SK44
    Conserved Domains (3) summary
    PHA02782
    Location:43 → 328
    PHA02782; hypothetical protein; Provisional
    pfam09848
    Location:571 → 759
    DUF2075; Uncharacterized conserved protein (DUF2075)
    cl28899
    Location:571 → 645
    DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily

  4. XM_006533579.3 → XP_006533642.1  schlafen family member 5 isoform X1

    See identical proteins and their annotated locations for XP_006533642.1

    UniProtKB/Swiss-Prot
    Q148Z1, Q3V3H0, Q5QNT5, Q7TMA8, Q8CBA2
    UniProtKB/TrEMBL
    A0A1G5SK44
    Conserved Domains (3) summary
    PHA02782
    Location:43 → 328
    PHA02782; hypothetical protein; Provisional
    pfam09848
    Location:571 → 759
    DUF2075; Uncharacterized conserved protein (DUF2075)
    cl28899
    Location:571 → 645
    DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily

  5. XM_036156778.1 → XP_036012671.1  schlafen family member 5 isoform X1

    UniProtKB/Swiss-Prot
    Q148Z1, Q3V3H0, Q5QNT5, Q7TMA8, Q8CBA2
    UniProtKB/TrEMBL
    A0A1G5SK44
    Conserved Domains (3) summary
    PHA02782
    Location:43 → 328
    PHA02782; hypothetical protein; Provisional
    pfam09848
    Location:571 → 759
    DUF2075; Uncharacterized conserved protein (DUF2075)
    cl28899
    Location:571 → 645
    DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily

  6. XM_036156777.1 → XP_036012670.1  schlafen family member 5 isoform X1

    UniProtKB/Swiss-Prot
    Q148Z1, Q3V3H0, Q5QNT5, Q7TMA8, Q8CBA2
    UniProtKB/TrEMBL
    A0A1G5SK44
    Conserved Domains (3) summary
    PHA02782
    Location:43 → 328
    PHA02782; hypothetical protein; Provisional
    pfam09848
    Location:571 → 759
    DUF2075; Uncharacterized conserved protein (DUF2075)
    cl28899
    Location:571 → 645
    DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily

  7. XM_017314616.3 → XP_017170105.1  schlafen family member 5 isoform X1

    UniProtKB/Swiss-Prot
    Q148Z1, Q3V3H0, Q5QNT5, Q7TMA8, Q8CBA2
    UniProtKB/TrEMBL
    A0A1G5SK44
    Conserved Domains (3) summary
    PHA02782
    Location:43 → 328
    PHA02782; hypothetical protein; Provisional
    pfam09848
    Location:571 → 759
    DUF2075; Uncharacterized conserved protein (DUF2075)
    cl28899
    Location:571 → 645
    DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily

  8. XM_017314615.3 → XP_017170104.1  schlafen family member 5 isoform X1

    UniProtKB/Swiss-Prot
    Q148Z1, Q3V3H0, Q5QNT5, Q7TMA8, Q8CBA2
    UniProtKB/TrEMBL
    A0A1G5SK44
    Conserved Domains (3) summary
    PHA02782
    Location:43 → 328
    PHA02782; hypothetical protein; Provisional
    pfam09848
    Location:571 → 759
    DUF2075; Uncharacterized conserved protein (DUF2075)
    cl28899
    Location:571 → 645
    DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CBA2.2 GenPept UniProtKB/Swiss-Prot:Q8CBA2

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