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Xaf1 XIAP associated factor 1 [ Mus musculus (house mouse) ]

Gene ID: 327959, updated on 5-Mar-2024

Summary

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Official Symbol
Xaf1provided by MGI
Official Full Name
XIAP associated factor 1provided by MGI
Primary source
MGI:MGI:3772572
See related
Ensembl:ENSMUSG00000040483 AllianceGenome:MGI:3772572
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fbox39
Summary
Predicted to enable metal ion binding activity. Predicted to be involved in response to interferon-beta. Predicted to act upstream of or within apoptotic process. Predicted to be located in mitochondrion and nucleoplasm. Is expressed in embryo. Orthologous to human XAF1 (XIAP associated factor 1). [provided by Alliance of Genome Resources, Apr 2022]
Annotation information
Note: On NCBI's build 37.1 (2007), this geneID was incorrectly annotated as Fbxo39. The correct location of Fbxo39 corresponds to geneID: 628100. [03 Mar 2008]
Expression
Broad expression in lung adult (RPKM 11.5), mammary gland adult (RPKM 10.9) and 22 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 B4; 11 43.99 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (72192229..72204560)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (72301461..72313733)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 13 (sodium-dependent citrate transporter), member 5 Neighboring gene predicted gene, 34252 Neighboring gene RIKEN cDNA 1700051A21 gene Neighboring gene STARR-seq mESC enhancer starr_29902 Neighboring gene F-box protein 39 Neighboring gene predicted gene, 51867 Neighboring gene tektin 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. XAF1 overexpression exacerbates diabetes by promoting pancreatic β-cell apoptosis. Nishimura Y, et al. Acta Diabetol, 2022 Oct. PMID 35829914, Free PMC Article
  2. SARM1 deficiency up-regulates XAF1, promotes neuronal apoptosis, and accelerates prion disease. Zhu C, et al. J Exp Med, 2019 Apr 1. PMID 30842236, Free PMC Article
  3. Metabolic Endotoxemia-Activated Macrophages Promote Pancreatic β Cell Death via IFNβ-Xaf1 Pathway. Tsuruta M, et al. Horm Metab Res, 2018 Feb. PMID 29132171
  4. XAF1 promotes neuroblastoma tumor suppression and is required for KIF1Bβ-mediated apoptosis. Choo Z, et al. Oncotarget, 2016 Jun 7. PMID 27097110, Free PMC Article
  5. XIAP-associated factor 1 (XAF1) suppresses angiogenesis in mouse endothelial cells. Qiao L, et al. Tumour Biol, 2008. PMID 18544999

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. XAF1 promotes anti-RNA virus immune responses by regulating chromatin accessibility.
    Title: XAF1 promotes anti-RNA virus immune responses by regulating chromatin accessibility.
  2. Identification of XAF1 as an endogenous AKT inhibitor.
    Title: Identification of XAF1 as an endogenous AKT inhibitor.
  3. XAF1 prevents hyperproduction of type I interferon upon viral infection by targeting IRF7.
    Title: XAF1 prevents hyperproduction of type I interferon upon viral infection by targeting IRF7.
  4. XAF1 Protects Host against Emerging RNA Viruses by Stabilizing IRF1-Dependent Antiviral Immunity.
    Title: XAF1 Protects Host against Emerging RNA Viruses by Stabilizing IRF1-Dependent Antiviral Immunity.
  5. XAF1 overexpression exacerbates diabetes by promoting pancreatic beta-cell apoptosis.
    Title: XAF1 overexpression exacerbates diabetes by promoting pancreatic β-cell apoptosis.
  6. Macrophages activated by metabolic endotoxemia infiltrated into islets and produced IFNbeta, which induced beta-cell apoptosis by increasing the expression of Xaf1.
    Title: Metabolic Endotoxemia-Activated Macrophages Promote Pancreatic β Cell Death via IFNβ-Xaf1 Pathway.
  7. XAF1 may be a candidate tumor suppressor in neuroblastoma
    Title: XAF1 promotes neuroblastoma tumor suppression and is required for KIF1Bβ-mediated apoptosis.
  8. XAF1 possesses a potential antiangiogenesis effect. Suppressed expression of Tie-1, Ang-1, Ang-2 and c-Myc may be mechanistically responsible for the observed antiangiogenesis effect.
    Title: XIAP-associated factor 1 (XAF1) suppresses angiogenesis in mouse endothelial cells.
  9. Interferon gamma induces XAF1 and Noxa expression and potentiates apoptosis by STAT3 activation
    Title: Interferon-gamma induces X-linked inhibitor of apoptosis-associated factor-1 and Noxa expression and potentiates human vascular smooth muscle cell apoptosis by STAT3 activation.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular sequestering activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of type I interferon production ISO
Inferred from Sequence Orthology
more info
  
involved_in response to interferon-beta ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
XIAP-associated factor 1
Names
BIRC4-binding protein
F-box protein 39
novel TRAF-type zinc finger protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037713.4 → NP_001032802.2  XIAP-associated factor 1 isoform 1

    See identical proteins and their annotated locations for NP_001032802.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK046736, AK140315, AL929071
    Consensus CDS
    CCDS24984.2
    UniProtKB/Swiss-Prot
    B7ZD14, Q3USK3, Q5NBU6, Q5NBU7, Q5NBU8, Q5NBU9
    Related
    ENSMUSP00000123011.2, ENSMUST00000146233.8
    Conserved Domains (1) summary
    PLN03086
    Location:1 → 108
    PLN03086; PRLI-interacting factor K; Provisional

  2. NM_001291153.1 → NP_001278082.1  XIAP-associated factor 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two exons in the central coding region but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
    Source sequence(s)
    AK046736, AK140315, AL929071
    Consensus CDS
    CCDS70236.1
    UniProtKB/TrEMBL
    A0A6G7MAJ9
    Related
    ENSMUSP00000121472.3, ENSMUST00000140842.9
    Conserved Domains (1) summary
    PLN03086
    Location:1 → 59
    PLN03086; PRLI-interacting factor K; Provisional

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    72192229..72204560
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017314613.3 → XP_017170102.1  XIAP-associated factor 1 isoform X2

    Conserved Domains (2) summary
    PLN03086
    Location:1 → 108
    PLN03086; PRLI-interacting factor K; Provisional
    pfam18608
    Location:228 → 270
    XAF1_C; XIAP-associated factor 1 C-terminal domain

  2. XM_017314614.3 → XP_017170103.1  XIAP-associated factor 1 isoform X4

    UniProtKB/TrEMBL
    A0A6G7MA53
    Conserved Domains (1) summary
    PLN03086
    Location:1 → 108
    PLN03086; PRLI-interacting factor K; Provisional

  3. XM_036156775.1 → XP_036012668.1  XIAP-associated factor 1 isoform X6

    UniProtKB/TrEMBL
    A0A6G7MAJ9
    Conserved Domains (2) summary
    PLN03086
    Location:1 → 59
    PLN03086; PRLI-interacting factor K; Provisional
    pfam18608
    Location:133 → 175
    XAF1_C; XIAP-associated factor 1 C-terminal domain

  4. XM_006533570.5 → XP_006533633.1  XIAP-associated factor 1 isoform X5

    UniProtKB/TrEMBL
    A0A6G7MA53
    Conserved Domains (1) summary
    PLN03086
    Location:1 → 108
    PLN03086; PRLI-interacting factor K; Provisional

  5. XM_006533567.5 → XP_006533630.1  XIAP-associated factor 1 isoform X1

    Conserved Domains (2) summary
    PLN03086
    Location:1 → 108
    PLN03086; PRLI-interacting factor K; Provisional
    pfam18608
    Location:228 → 260
    XAF1_C; XIAP-associated factor 1 C-terminal domain

  6. XM_006533569.5 → XP_006533632.1  XIAP-associated factor 1 isoform X3

    UniProtKB/TrEMBL
    Z4YN17
    Related
    ENSMUSP00000121483.2, ENSMUST00000151440.8
    Conserved Domains (2) summary
    PLN03086
    Location:1 → 59
    PLN03086; PRLI-interacting factor K; Provisional
    pfam18608
    Location:133 → 165
    XAF1_C; XIAP-associated factor 1 C-terminal domain

  7. XM_011249084.4 → XP_011247386.1  XIAP-associated factor 1 isoform X7

    Conserved Domains (1) summary
    PLN03086
    Location:1 → 108
    PLN03086; PRLI-interacting factor K; Provisional
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5NBU8.3 GenPept UniProtKB/Swiss-Prot:Q5NBU8

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