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Dnah2 dynein, axonemal, heavy chain 2 [ Mus musculus (house mouse) ]

Gene ID: 327954, updated on 11-Apr-2024

Summary

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Official Symbol
Dnah2provided by MGI
Official Full Name
dynein, axonemal, heavy chain 2provided by MGI
Primary source
MGI:MGI:107731
See related
Ensembl:ENSMUSG00000005237 AllianceGenome:MGI:107731
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Dnhd3; Dnahc2; 4930564A01; D130094J20; 2900022L05Rik; D330014H01Rik
Summary
Predicted to enable dynein intermediate chain binding activity; dynein light intermediate chain binding activity; and minus-end-directed microtubule motor activity. Predicted to be involved in cilium-dependent cell motility and microtubule-based movement. Located in motile cilium. Is expressed in central nervous system. Human ortholog(s) of this gene implicated in spermatogenic failure 45. Orthologous to human DNAH2 (dynein axonemal heavy chain 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 9.8), ovary adult (RPKM 1.9) and 5 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 B3; 11 42.63 cM
Exon count:
95
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (69311635..69439934, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (69420807..69549108, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5241 Neighboring gene STARR-positive B cell enhancer ABC_E2996 Neighboring gene STARR-positive B cell enhancer ABC_E5242 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:69223376-69223485 Neighboring gene transmembrane protein 88 Neighboring gene N(alpha)-acetyltransferase 38, NatC auxiliary subunit Neighboring gene KDM1 lysine (K)-specific demethylase 6B Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:69231989-69232098 Neighboring gene predicted gene, 51903 Neighboring gene STARR-seq mESC enhancer starr_29847 Neighboring gene STARR-seq mESC enhancer starr_29849 Neighboring gene ephrin B3 Neighboring gene WD repeat containing, antisense to Trp53 Neighboring gene ribosomal protein S27, pseudogene 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Genetic Defects in DNAH2 Underlie Male Infertility With Multiple Morphological Abnormalities of the Sperm Flagella in Humans and Mice. Hwang JY, et al. Front Cell Dev Biol, 2021. PMID 33968937, Free PMC Article
  2. Vertebrate Dynein-f depends on Wdr78 for axonemal localization and is essential for ciliary beat. Zhang Y, et al. J Mol Cell Biol, 2019 May 1. PMID 30060180, Free PMC Article
  3. Left-right asymmetry and kinesin superfamily protein KIF3A: new insights in determination of laterality and mesoderm induction by kif3A-/- mice analysis. Takeda S, et al. J Cell Biol, 1999 May 17. PMID 10330409, Free PMC Article
  4. Dynein and kinesin regulate stress-granule and P-body dynamics. Loschi M, et al. J Cell Sci, 2009 Nov 1. PMID 19825938, Free PMC Article
  5. Identification of dynein heavy chain genes expressed in human and mouse testis: chromosomal localization of an axonemal dynein gene. Neesen J, et al. Gene, 1997 Oct 24. PMID 9373155

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables dynein intermediate chain binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dynein light intermediate chain binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables minus-end-directed microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cilium movement IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cilium movement involved in cell motility IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cilium-dependent cell motility ISO
Inferred from Sequence Orthology
more info
  
involved_in inner dynein arm assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in microtubule-based movement IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in 9+2 motile cilium IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of axonemal dynein complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in axoneme IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in axoneme ISO
Inferred from Sequence Orthology
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cilium IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
part_of dynein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of inner dynein arm ISM
Inferred from Sequence Model
more info
 PubMed 
part_of inner dynein arm ISO
Inferred from Sequence Orthology
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
located_in motile cilium IDA
Inferred from Direct Assay
more info
 PubMed 
located_in motile cilium ISO
Inferred from Sequence Orthology
more info
  
located_in sperm flagellum ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
dynein axonemal heavy chain 2
Names
axonemal beta dynein heavy chain 2
axonemal dynein heavy chain
ciliary dynein heavy chain 2
dynein heavy chain 2, axonemal
dynein heavy chain domain 3
dynein, axon, heavy chain 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081330.1 → NP_001074799.1  dynein axonemal heavy chain 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL596125, AL731687
    Consensus CDS
    CCDS36192.1
    UniProtKB/Swiss-Prot
    B1AR18, O08826, P0C6F1, Q8C0U5
    UniProtKB/TrEMBL
    D3Z667, Q5F222
    Related
    ENSMUSP00000104299.2, ENSMUST00000108659.2
    Conserved Domains (6) summary
    pfam03028
    Location:3759 → 4450
    Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
    pfam08385
    Location:275 → 760
    DHC_N1; Dynein heavy chain, N-terminal region 1
    pfam08393
    Location:1258 → 1663
    DHC_N2; Dynein heavy chain, N-terminal region 2
    pfam12777
    Location:3041 → 3373
    MT; Microtubule-binding stalk of dynein motor
    pfam12781
    Location:3401 → 3617
    AAA_9; ATP-binding dynein motor region D5
    cl21455
    Location:1800 → 2030
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  2. NM_001419927.1 → NP_001406856.1  dynein axonemal heavy chain 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL596125, AL731687

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    69311635..69439934 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036156769.1 → XP_036012662.1  dynein axonemal heavy chain 2 isoform X3

    UniProtKB/Swiss-Prot
    B1AR18, O08826, P0C6F1, Q8C0U5
    UniProtKB/TrEMBL
    Q5F222
    Conserved Domains (6) summary
    COG5245
    Location:1373 → 4040
    DYN1; Dynein, heavy chain [Cytoskeleton]
    pfam08385
    Location:241 → 798
    DHC_N1; Dynein heavy chain, N-terminal region 1
    pfam12774
    Location:1846 → 2172
    AAA_6; Hydrolytic ATP binding site of dynein motor region D1
    pfam12780
    Location:2813 → 3073
    AAA_8; P-loop containing dynein motor region D4
    pfam18198
    Location:4032 → 4134
    AAA_lid_11; Dynein heavy chain AAA lid domain
    pfam18199
    Location:4140 → 4440
    Dynein_C; Dynein heavy chain C-terminal domain

  2. XM_030246089.2 → XP_030101949.1  dynein axonemal heavy chain 2 isoform X2

    UniProtKB/Swiss-Prot
    B1AR18, O08826, P0C6F1, Q8C0U5
    UniProtKB/TrEMBL
    Q5F222
    Conserved Domains (5) summary
    COG5245
    Location:1312 → 4128
    DYN1; Dynein, heavy chain [Cytoskeleton]
    pfam08385
    Location:180 → 737
    DHC_N1; Dynein heavy chain, N-terminal region 1
    pfam08393
    Location:1240 → 1648
    DHC_N2; Dynein heavy chain, N-terminal region 2
    pfam12774
    Location:1785 → 2111
    AAA_6; Hydrolytic ATP binding site of dynein motor region D1
    pfam18199
    Location:4143 → 4443
    Dynein_C; Dynein heavy chain C-terminal domain

  3. XM_036156771.1 → XP_036012664.1  dynein axonemal heavy chain 2 isoform X5

    UniProtKB/Swiss-Prot
    B1AR18, O08826, P0C6F1, Q8C0U5
    UniProtKB/TrEMBL
    Q5F222
    Conserved Domains (5) summary
    COG5245
    Location:1373 → 4090
    DYN1; Dynein, heavy chain [Cytoskeleton]
    pfam08385
    Location:241 → 798
    DHC_N1; Dynein heavy chain, N-terminal region 1
    pfam12774
    Location:1846 → 2172
    AAA_6; Hydrolytic ATP binding site of dynein motor region D1
    pfam12780
    Location:2714 → 2974
    AAA_8; P-loop containing dynein motor region D4
    pfam18199
    Location:4105 → 4405
    Dynein_C; Dynein heavy chain C-terminal domain

  4. XM_036156770.1 → XP_036012663.1  dynein axonemal heavy chain 2 isoform X4

    UniProtKB/Swiss-Prot
    B1AR18, O08826, P0C6F1, Q8C0U5
    UniProtKB/TrEMBL
    Q5F222
    Conserved Domains (4) summary
    COG5245
    Location:1301 → 4117
    DYN1; Dynein, heavy chain [Cytoskeleton]
    pfam08385
    Location:169 → 726
    DHC_N1; Dynein heavy chain, N-terminal region 1
    pfam12774
    Location:1774 → 2100
    AAA_6; Hydrolytic ATP binding site of dynein motor region D1
    pfam18199
    Location:4132 → 4432
    Dynein_C; Dynein heavy chain C-terminal domain

  5. XM_006533559.3 → XP_006533622.1  dynein axonemal heavy chain 2 isoform X7

    See identical proteins and their annotated locations for XP_006533622.1

    UniProtKB/Swiss-Prot
    B1AR18, O08826, P0C6F1, Q8C0U5
    UniProtKB/TrEMBL
    Q5F222
    Conserved Domains (5) summary
    COG5245
    Location:634 → 3450
    DYN1; Dynein, heavy chain [Cytoskeleton]
    pfam08385
    Location:1 → 59
    DHC_N1; Dynein heavy chain, N-terminal region 1
    pfam08393
    Location:562 → 970
    DHC_N2; Dynein heavy chain, N-terminal region 2
    pfam12774
    Location:1107 → 1433
    AAA_6; Hydrolytic ATP binding site of dynein motor region D1
    pfam18199
    Location:3465 → 3765
    Dynein_C; Dynein heavy chain C-terminal domain

  6. XM_006533560.5 → XP_006533623.1  dynein axonemal heavy chain 2 isoform X7

    See identical proteins and their annotated locations for XP_006533623.1

    UniProtKB/Swiss-Prot
    B1AR18, O08826, P0C6F1, Q8C0U5
    UniProtKB/TrEMBL
    Q5F222
    Conserved Domains (5) summary
    COG5245
    Location:634 → 3450
    DYN1; Dynein, heavy chain [Cytoskeleton]
    pfam08385
    Location:1 → 59
    DHC_N1; Dynein heavy chain, N-terminal region 1
    pfam08393
    Location:562 → 970
    DHC_N2; Dynein heavy chain, N-terminal region 2
    pfam12774
    Location:1107 → 1433
    AAA_6; Hydrolytic ATP binding site of dynein motor region D1
    pfam18199
    Location:3465 → 3765
    Dynein_C; Dynein heavy chain C-terminal domain

  7. XM_017314611.3 → XP_017170100.1  dynein axonemal heavy chain 2 isoform X7

    UniProtKB/Swiss-Prot
    B1AR18, O08826, P0C6F1, Q8C0U5
    UniProtKB/TrEMBL
    Q5F222
    Conserved Domains (5) summary
    COG5245
    Location:634 → 3450
    DYN1; Dynein, heavy chain [Cytoskeleton]
    pfam08385
    Location:1 → 59
    DHC_N1; Dynein heavy chain, N-terminal region 1
    pfam08393
    Location:562 → 970
    DHC_N2; Dynein heavy chain, N-terminal region 2
    pfam12774
    Location:1107 → 1433
    AAA_6; Hydrolytic ATP binding site of dynein motor region D1
    pfam18199
    Location:3465 → 3765
    Dynein_C; Dynein heavy chain C-terminal domain

  8. XM_030246092.1 → XP_030101952.1  dynein axonemal heavy chain 2 isoform X9

    Conserved Domains (4) summary
    COG5245
    Location:32 → 2432
    DYN1; Dynein, heavy chain [Cytoskeleton]
    pfam12774
    Location:89 → 415
    AAA_6; Hydrolytic ATP binding site of dynein motor region D1
    pfam12780
    Location:1056 → 1316
    AAA_8; P-loop containing dynein motor region D4
    pfam18199
    Location:2447 → 2747
    Dynein_C; Dynein heavy chain C-terminal domain

  9. XM_036156772.1 → XP_036012665.1  dynein axonemal heavy chain 2 isoform X6

    UniProtKB/Swiss-Prot
    B1AR18, O08826, P0C6F1, Q8C0U5
    UniProtKB/TrEMBL
    Q5F222
    Conserved Domains (4) summary
    COG5245
    Location:1373 → 4023
    DYN1; Dynein, heavy chain [Cytoskeleton]
    pfam08385
    Location:241 → 798
    DHC_N1; Dynein heavy chain, N-terminal region 1
    pfam12774
    Location:1846 → 2172
    AAA_6; Hydrolytic ATP binding site of dynein motor region D1
    pfam12780
    Location:2813 → 3073
    AAA_8; P-loop containing dynein motor region D4

  10. XM_036156773.1 → XP_036012666.1  dynein axonemal heavy chain 2 isoform X8

    Conserved Domains (8) summary
    pfam12777
    Location:3087 → 3229
    MT; Microtubule-binding stalk of dynein motor
    pfam17857
    Location:2669 → 2759
    AAA_lid_1; AAA+ lid domain
    pfam08385
    Location:241 → 798
    DHC_N1; Dynein heavy chain, N-terminal region 1
    pfam08393
    Location:1301 → 1709
    DHC_N2; Dynein heavy chain, N-terminal region 2
    pfam12774
    Location:1846 → 2172
    AAA_6; Hydrolytic ATP binding site of dynein motor region D1
    pfam12775
    Location:2458 → 2638
    AAA_7; P-loop containing dynein motor region D3
    pfam12780
    Location:2813 → 3073
    AAA_8; P-loop containing dynein motor region D4
    pfam17852
    Location:2334 → 2452
    Dynein_AAA_lid; Dynein heavy chain AAA lid domain

RNA

  1. XR_004936978.1 RNA Sequence

  2. XR_004936979.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_177617.2: Suppressed sequence

    Description
    NM_177617.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0C6F1.1 GenPept UniProtKB/Swiss-Prot:P0C6F1

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