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Frs2 fibroblast growth factor receptor substrate 2 [ Mus musculus (house mouse) ]

Gene ID: 327826, updated on 11-Apr-2024

Summary

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Official Symbol
Frs2provided by MGI
Official Full Name
fibroblast growth factor receptor substrate 2provided by MGI
Primary source
MGI:MGI:1100860
See related
Ensembl:ENSMUSG00000020170 AllianceGenome:MGI:1100860
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SNT1; SNT-1; Frs2alpha; FRS2-alpha; C330018A15Rik
Summary
Enables transmembrane receptor protein tyrosine kinase adaptor activity. Acts upstream of or within several processes, including animal organ development; organ induction; and regulation of MAPK cascade. Located in cell-cell junction; cytoplasm; and plasma membrane. Is expressed in several structures, including alimentary system; blastocyst; central nervous system; genitourinary system; and immune system. Orthologous to human FRS2 (fibroblast growth factor receptor substrate 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in limb E14.5 (RPKM 13.1), CNS E14 (RPKM 10.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Frs2 in Genome Data Viewer
Location:
10 D2; 10 65.09 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (116905324..116986311, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (117070127..117148474, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing 10 Neighboring gene STARR-positive B cell enhancer ABC_E2966 Neighboring gene chaperonin containing TCP1 subunit 2 Neighboring gene STARR-positive B cell enhancer ABC_E8366 Neighboring gene STARR-seq mESC enhancer starr_27971 Neighboring gene predicted gene, 40811 Neighboring gene predicted gene, 53635 Neighboring gene RIKEN cDNA 4930423D24 gene Neighboring gene predicted gene, 40769

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. FRS2α is essential for the fibroblast growth factor to regulate the mTOR pathway and autophagy in mouse embryonic fibroblasts. Lin X, et al. Int J Biol Sci, 2011. PMID 21927580, Free PMC Article
  2. FRS2α-dependent cell fate transition during endocardial cushion morphogenesis. Chen D, et al. Dev Biol, 2020 Feb 1. PMID 31669335
  3. Neurotrophin and FGF Signaling Adapter Proteins, FRS2 and FRS3, Regulate Dentate Granule Cell Maturation and Excitatory Synaptogenesis. Nandi S, et al. Neuroscience, 2018 Jan 15. PMID 29155277, Free PMC Article
  4. Six2creFrs2α knockout mice are a novel model of renal cystogenesis. Puri P, et al. Sci Rep, 2016 Nov 17. PMID 27853247, Free PMC Article
  5. FRS2α regulates Erk levels to control a self-renewal target Hes1 and proliferation of FGF-responsive neural stem/progenitor cells. Sato T, et al. Stem Cells, 2010 Sep. PMID 20652960, Free PMC Article

See all (100) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. FRS2-independent GRB2 interaction with FGFR2 is not required for embryonic development.
    Title: FRS2-independent GRB2 interaction with FGFR2 is not required for embryonic development.
  2. FRS2alpha-dependent cell fate transition during endocardial cushion morphogenesis.
    Title: FRS2α-dependent cell fate transition during endocardial cushion morphogenesis.
  3. FRS2 and FRS3, are together required for postnatal brain development. In the hippocampus, FRS2&3 promote dentate gyrus morphogenesis and dentate granule cell (DGC) maturation during developmental neurogenesis. Frs2,3-double mutants have reduced numbers of dendritic branches and spines in DGCs. Double-mutant mice exhibit fewer excitatory synaptic inputs onto DGCs.
    Title: Neurotrophin and FGF Signaling Adapter Proteins, FRS2 and FRS3, Regulate Dentate Granule Cell Maturation and Excitatory Synaptogenesis.
  4. FRS2alpha-mediated pathways are essential for the FGF15/FGF19-FGFR4 signaling axis to control bile acid homeostasis.
    Title: Hepatocyte FRS2α is essential for the endocrine fibroblast growth factor to limit the amplitude of bile acid production induced by prandial activity.
  5. controlsConclusionFrs2alpha(ST-/-) embryos have aberrant ureteric induction sites, improper ureteral insertion, shortened intravesicular lengths, and VUR
    Title: Loss of peri-Wolffian duct stromal Frs2α expression in mice leads to abnormal ureteric bud induction and vesicoureteral reflux.
  6. Embryonic day 18.5 Six2Frs2alphaKO kidneys were hypoplastic and not cystic, postnatal day (P) 7 mutants had proximal tubular-derived cysts that nearly replaced the renal parenchyma by P21. Mutants had high proximal tubular proliferation rates and interstitial fibrosis, similar to known polycystic kidney disease models.
    Title: Six2creFrs2α knockout mice are a novel model of renal cystogenesis.
  7. Fgfr signaling in nephron progenitors appears to be mediated predominantly by Frs2alpha.
    Title: Fibroblast growth factor receptor-Frs2α signaling is critical for nephron progenitors.
  8. Analysis of a mutant Fgfr1 allele, unable to bind to the adaptor protein, Frs2/3, indicates that Sox2 maintenance can be regulated by MAP kinase.
    Title: FGFR1-Frs2/3 signalling maintains sensory progenitors during inner ear hair cell formation.
  9. data from two models showed that FRS2 played different roles in the regulation of two activity levels of the ERK pathway components in the epididymis.
    Title: The Role of fibroblast growth factor receptor substrate 2 (FRS2) in the regulation of two activity levels of the components of the extracellular signal-regulated kinase (ERK) pathway in the mouse epididymis.
  10. Genetic evidence further supports that the formation of an Frs2alpha-Shp2 complex and its recruitment to FGF receptors are crucial for downstream ERK signaling in this process.
    Title: Deficient FGF signaling causes optic nerve dysgenesis and ocular coloboma.
Submit: New GeneRIF Correction See all GeneRIFs (37)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables fibroblast growth factor receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables fibroblast growth factor receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables neurotrophin TRKA receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transmembrane receptor protein tyrosine kinase adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane receptor protein tyrosine kinase adaptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within anterior/posterior axis specification, embryo IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cell surface receptor protein tyrosine kinase signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cellular response to fibroblast growth factor stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in fibroblast growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within fibroblast growth factor receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within fibroblast growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within fibroblast growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within forebrain development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within gastrulation with mouth forming second IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within lens development in camera-type eye IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within lens fiber cell development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within lens fiber cell development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within lens placode formation involved in camera-type eye formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of cardiac muscle cell differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within neuroblast proliferation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within neuroblast proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within organ induction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of MAPK cascade IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of vascular associated smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of epithelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within ventricular septum development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in adherens junction ISO
Inferred from Sequence Orthology
more info
  
is_active_in cell-cell junction IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cell-cell junction IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
fibroblast growth factor receptor substrate 2
Names
FGFR substrate 2
FGFR-signaling adaptor SNT
suc1-associated neurotrophic factor target 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001408282.1 → NP_001395211.1  fibroblast growth factor receptor substrate 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL589661
    UniProtKB/Swiss-Prot
    Q8C180

  2. NM_001408283.1 → NP_001395212.1  fibroblast growth factor receptor substrate 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL589661
    UniProtKB/Swiss-Prot
    Q8C180

  3. NM_001408284.1 → NP_001395213.1  fibroblast growth factor receptor substrate 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL589661
    UniProtKB/Swiss-Prot
    Q8C180

  4. NM_001408285.1 → NP_001395214.1  fibroblast growth factor receptor substrate 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL589661
    UniProtKB/Swiss-Prot
    Q8C180

  5. NM_001408286.1 → NP_001395215.1  fibroblast growth factor receptor substrate 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL589661
    UniProtKB/Swiss-Prot
    Q8C180

  6. NM_001408287.1 → NP_001395216.1  fibroblast growth factor receptor substrate 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL589661
    UniProtKB/Swiss-Prot
    Q8C180

  7. NM_001408288.1 → NP_001395217.1  fibroblast growth factor receptor substrate 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL589661
    UniProtKB/Swiss-Prot
    Q8C180

  8. NM_001408289.1 → NP_001395218.1  fibroblast growth factor receptor substrate 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL589661
    UniProtKB/Swiss-Prot
    Q8C180

  9. NM_001408290.1 → NP_001395219.1  fibroblast growth factor receptor substrate 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL589661
    UniProtKB/Swiss-Prot
    Q8C180

  10. NM_001408291.1 → NP_001395220.1  fibroblast growth factor receptor substrate 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL589661
    UniProtKB/Swiss-Prot
    Q8C180

  11. NM_001408292.1 → NP_001395221.1  fibroblast growth factor receptor substrate 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL589661
    UniProtKB/Swiss-Prot
    Q8C180

  12. NM_001408293.1 → NP_001395222.1  fibroblast growth factor receptor substrate 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL589661
    UniProtKB/Swiss-Prot
    Q8C180

  13. NM_001408294.1 → NP_001395223.1  fibroblast growth factor receptor substrate 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL589661
    UniProtKB/Swiss-Prot
    Q8C180

  14. NM_001408295.1 → NP_001395224.1  fibroblast growth factor receptor substrate 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL589661
    UniProtKB/Swiss-Prot
    Q8C180

  15. NM_001408296.1 → NP_001395225.1  fibroblast growth factor receptor substrate 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL589661
    UniProtKB/Swiss-Prot
    Q8C180

  16. NM_001408297.1 → NP_001395226.1  fibroblast growth factor receptor substrate 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL589661
    UniProtKB/Swiss-Prot
    Q8C180

  17. NM_001408308.1 → NP_001395237.1  fibroblast growth factor receptor substrate 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL589661

  18. NM_001408309.1 → NP_001395238.1  fibroblast growth factor receptor substrate 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL589661

  19. NM_001408310.1 → NP_001395239.1  fibroblast growth factor receptor substrate 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL589661

  20. NM_001408311.1 → NP_001395240.1  fibroblast growth factor receptor substrate 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL589661

  21. NM_001408312.1 → NP_001395241.1  fibroblast growth factor receptor substrate 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL589661

  22. NM_001408313.1 → NP_001395242.1  fibroblast growth factor receptor substrate 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL589661

  23. NM_001408314.1 → NP_001395243.1  fibroblast growth factor receptor substrate 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL589661

  24. NM_177798.4 → NP_808466.1  fibroblast growth factor receptor substrate 2 isoform 1

    See identical proteins and their annotated locations for NP_808466.1

    Status: VALIDATED

    Source sequence(s)
    AL589661
    Consensus CDS
    CCDS24190.1
    UniProtKB/Swiss-Prot
    Q8C180
    Related
    ENSMUSP00000020381.4, ENSMUST00000020381.5
    Conserved Domains (1) summary
    cd01202
    Location:15 → 106
    PTB_FRS2; Fibroblast growth factor receptor substrate 2 phosphotyrosine-binding domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    116905324..116986311 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8C180.3 GenPept UniProtKB/Swiss-Prot:Q8C180

Gene LinkOut

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