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Usp44 ubiquitin specific peptidase 44 [ Mus musculus (house mouse) ]

Gene ID: 327799, updated on 11-Apr-2024

Summary

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Official Symbol
Usp44provided by MGI
Official Full Name
ubiquitin specific peptidase 44provided by MGI
Primary source
MGI:MGI:3045318
See related
Ensembl:ENSMUSG00000020020 AllianceGenome:MGI:3045318
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
E430004F17Rik
Summary
Predicted to enable thiol-dependent deubiquitinase. Involved in chromosome segregation; proteasome-mediated ubiquitin-dependent protein catabolic process; and regulation of mitotic cell cycle spindle assembly checkpoint. Located in nucleus. Orthologous to human USP44 (ubiquitin specific peptidase 44). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 24.5), CNS E11.5 (RPKM 1.5) and 1 other tissue See more
Orthologs
human all
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Genomic context

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Location:
10 C2; 10 48.67 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (93655831..93696792)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (93819969..93859425)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene farnesyl diphosphate synthetase pseudogene Neighboring gene STARR-seq mESC enhancer starr_27591 Neighboring gene STARR-positive B cell enhancer mm9_chr10:93281373-93281673 Neighboring gene STARR-seq mESC enhancer starr_27592 Neighboring gene predicted gene, 26239 Neighboring gene STARR-seq mESC enhancer starr_27593 Neighboring gene methionine aminopeptidase 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:93352494-93352603 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:93401444-93401825 Neighboring gene STARR-seq mESC enhancer starr_27594 Neighboring gene microRNA 331 Neighboring gene vezatin, adherens junctions transmembrane protein Neighboring gene mitochondrial inner membrane protease subunit 1 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. USP44 is dispensable for normal hematopoietic stem cell function, lymphocyte development, and B-cell-mediated immune response in a mouse model. Lin YH, et al. Exp Hematol, 2019 Apr. PMID 30639577
  2. RNF20 and USP44 regulate stem cell differentiation by modulating H2B monoubiquitylation. Fuchs G, et al. Mol Cell, 2012 Jun 8. PMID 22681888, Free PMC Article
  3. Overexpression of ubiquitin specific protease 44 (USP44) induces chromosomal instability and is frequently observed in human T-cell leukemia. Zhang Y, et al. PLoS One, 2011. PMID 21853124, Free PMC Article
  4. USP44 Stabilizes DDB2 to Facilitate Nucleotide Excision Repair and Prevent Tumors. Zhang Y, et al. Front Cell Dev Biol, 2021. PMID 33937266, Free PMC Article
  5. USP44 regulates centrosome positioning to prevent aneuploidy and suppress tumorigenesis. Zhang Y, et al. J Clin Invest, 2012 Dec. PMID 23187126, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. USP44 is dispensable for the normal physiology of hematopoietic and immune systems, and its functions in these systems are likely redundant with other USP family proteins.
    Title: USP44 is dispensable for normal hematopoietic stem cell function, lymphocyte development, and B-cell-mediated immune response in a mouse model.
  2. USP44 inhibited chromosome segregation errors independent of its role in the mitotic checkpoint by regulating centrosome separation, positioning, and mitotic spindle geometry.
    Title: USP44 regulates centrosome positioning to prevent aneuploidy and suppress tumorigenesis.
  3. These data are consistent with an important role for USP44 in regulating Cdc20-APC/C activity and suggest that high levels of this enzyme may contribute to the pathogenesis of T-cell leukemias.
    Title: Overexpression of ubiquitin specific protease 44 (USP44) induces chromosomal instability and is frequently observed in human T-cell leukemia.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (5)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cysteine-type deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
  
enables cysteine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in antiviral innate immune response ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in chromosome segregation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of mitotic metaphase/anaphase transition ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein deubiquitination ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of mitotic cell cycle spindle assembly checkpoint IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulatory T cell differentiation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ubiquitin carboxyl-terminal hydrolase 44
Names
deubiquitinating enzyme 44
inactive deubiquitinating enzyme 44
inactive ubiquitin carboxyl-terminal hydrolase 44
inactive ubiquitin thioesterase 44
inactive ubiquitin-specific-processing protease 44
ubiquitin specific peptidase 49 pseudogene
ubiquitin thioesterase 44
NP_001193780.1
NP_001363910.1
NP_001387910.1
XP_011241782.1
XP_011241783.1
XP_011241784.1
XP_011241785.1
XP_011241786.1
XP_011241787.1
XP_011241788.1
XP_011241789.1
XP_011241790.1
XP_011241791.1
XP_011241792.1
XP_030100994.1
XP_030100996.1
XP_036011718.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001206851.3 → NP_001193780.1  ubiquitin carboxyl-terminal hydrolase 44

    See identical proteins and their annotated locations for NP_001193780.1

    Status: VALIDATED

    Source sequence(s)
    AC124686
    Consensus CDS
    CCDS88075.1
    UniProtKB/Swiss-Prot
    Q8C2S0
    Conserved Domains (2) summary
    pfam00443
    Location:272 → 674
    UCH; Ubiquitin carboxyl-terminal hydrolase
    pfam02148
    Location:26 → 88
    zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

  2. NM_001376981.1 → NP_001363910.1  ubiquitin carboxyl-terminal hydrolase 44

    Status: VALIDATED

    Source sequence(s)
    AC124686
    UniProtKB/Swiss-Prot
    Q8C2S0
    Conserved Domains (2) summary
    pfam00443
    Location:272 → 674
    UCH; Ubiquitin carboxyl-terminal hydrolase
    pfam02148
    Location:26 → 88
    zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

  3. NM_001400981.1 → NP_001387910.1  ubiquitin carboxyl-terminal hydrolase 44

    Status: VALIDATED

    Source sequence(s)
    AC124686
    UniProtKB/Swiss-Prot
    Q8C2S0
    Related
    ENSMUSP00000149020.2, ENSMUST00000216224.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    93655831..93696792
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011243480.4 → XP_011241782.1  ubiquitin carboxyl-terminal hydrolase 44 isoform X1

    See identical proteins and their annotated locations for XP_011241782.1

    UniProtKB/Swiss-Prot
    Q8C2S0
    Conserved Domains (2) summary
    pfam00443
    Location:272 → 674
    UCH; Ubiquitin carboxyl-terminal hydrolase
    pfam02148
    Location:26 → 88
    zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

  2. XM_011243484.3 → XP_011241786.1  ubiquitin carboxyl-terminal hydrolase 44 isoform X1

    See identical proteins and their annotated locations for XP_011241786.1

    UniProtKB/Swiss-Prot
    Q8C2S0
    Conserved Domains (2) summary
    pfam00443
    Location:272 → 674
    UCH; Ubiquitin carboxyl-terminal hydrolase
    pfam02148
    Location:26 → 88
    zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

  3. XM_011243483.3 → XP_011241785.1  ubiquitin carboxyl-terminal hydrolase 44 isoform X1

    See identical proteins and their annotated locations for XP_011241785.1

    UniProtKB/Swiss-Prot
    Q8C2S0
    Conserved Domains (2) summary
    pfam00443
    Location:272 → 674
    UCH; Ubiquitin carboxyl-terminal hydrolase
    pfam02148
    Location:26 → 88
    zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

  4. XM_011243485.3 → XP_011241787.1  ubiquitin carboxyl-terminal hydrolase 44 isoform X1

    See identical proteins and their annotated locations for XP_011241787.1

    UniProtKB/Swiss-Prot
    Q8C2S0
    Conserved Domains (2) summary
    pfam00443
    Location:272 → 674
    UCH; Ubiquitin carboxyl-terminal hydrolase
    pfam02148
    Location:26 → 88
    zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

  5. XM_011243481.4 → XP_011241783.1  ubiquitin carboxyl-terminal hydrolase 44 isoform X1

    See identical proteins and their annotated locations for XP_011241783.1

    UniProtKB/Swiss-Prot
    Q8C2S0
    Conserved Domains (2) summary
    pfam00443
    Location:272 → 674
    UCH; Ubiquitin carboxyl-terminal hydrolase
    pfam02148
    Location:26 → 88
    zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

  6. XM_011243487.4 → XP_011241789.1  ubiquitin carboxyl-terminal hydrolase 44 isoform X1

    See identical proteins and their annotated locations for XP_011241789.1

    UniProtKB/Swiss-Prot
    Q8C2S0
    Conserved Domains (2) summary
    pfam00443
    Location:272 → 674
    UCH; Ubiquitin carboxyl-terminal hydrolase
    pfam02148
    Location:26 → 88
    zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

  7. XM_011243489.4 → XP_011241791.1  ubiquitin carboxyl-terminal hydrolase 44 isoform X1

    See identical proteins and their annotated locations for XP_011241791.1

    UniProtKB/Swiss-Prot
    Q8C2S0
    Conserved Domains (2) summary
    pfam00443
    Location:272 → 674
    UCH; Ubiquitin carboxyl-terminal hydrolase
    pfam02148
    Location:26 → 88
    zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

  8. XM_030245136.2 → XP_030100996.1  ubiquitin carboxyl-terminal hydrolase 44 isoform X2

    Conserved Domains (2) summary
    pfam00443
    Location:272 → 480
    UCH; Ubiquitin carboxyl-terminal hydrolase
    pfam02148
    Location:26 → 88
    zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

  9. XM_011243490.4 → XP_011241792.1  ubiquitin carboxyl-terminal hydrolase 44 isoform X1

    See identical proteins and their annotated locations for XP_011241792.1

    UniProtKB/Swiss-Prot
    Q8C2S0
    Conserved Domains (2) summary
    pfam00443
    Location:272 → 674
    UCH; Ubiquitin carboxyl-terminal hydrolase
    pfam02148
    Location:26 → 88
    zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

  10. XM_011243482.3 → XP_011241784.1  ubiquitin carboxyl-terminal hydrolase 44 isoform X1

    See identical proteins and their annotated locations for XP_011241784.1

    UniProtKB/Swiss-Prot
    Q8C2S0
    Conserved Domains (2) summary
    pfam00443
    Location:272 → 674
    UCH; Ubiquitin carboxyl-terminal hydrolase
    pfam02148
    Location:26 → 88
    zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

  11. XM_030245134.2 → XP_030100994.1  ubiquitin carboxyl-terminal hydrolase 44 isoform X1

    UniProtKB/Swiss-Prot
    Q8C2S0
    Conserved Domains (2) summary
    pfam00443
    Location:272 → 674
    UCH; Ubiquitin carboxyl-terminal hydrolase
    pfam02148
    Location:26 → 88
    zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

  12. XM_036155825.1 → XP_036011718.1  ubiquitin carboxyl-terminal hydrolase 44 isoform X2

    Conserved Domains (2) summary
    pfam00443
    Location:272 → 480
    UCH; Ubiquitin carboxyl-terminal hydrolase
    pfam02148
    Location:26 → 88
    zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

  13. XM_011243486.3 → XP_011241788.1  ubiquitin carboxyl-terminal hydrolase 44 isoform X1

    See identical proteins and their annotated locations for XP_011241788.1

    UniProtKB/Swiss-Prot
    Q8C2S0
    Conserved Domains (2) summary
    pfam00443
    Location:272 → 674
    UCH; Ubiquitin carboxyl-terminal hydrolase
    pfam02148
    Location:26 → 88
    zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

  14. XM_011243488.3 → XP_011241790.1  ubiquitin carboxyl-terminal hydrolase 44 isoform X1

    See identical proteins and their annotated locations for XP_011241790.1

    UniProtKB/Swiss-Prot
    Q8C2S0
    Conserved Domains (2) summary
    pfam00443
    Location:272 → 674
    UCH; Ubiquitin carboxyl-terminal hydrolase
    pfam02148
    Location:26 → 88
    zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_183199.3: Suppressed sequence

    Description
    NM_183199.3: This RefSeq was removed because currently there is insufficient support for this transcript and protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8C2S0.3 GenPept UniProtKB/Swiss-Prot:Q8C2S0

Gene LinkOut

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