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CG18258 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32708, updated on 27-Mar-2024

Summary

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Official Symbol
CG18258provided by FlyBase
Primary source
FLYBASE:FBgn0265267
Locus tag
Dmel_CG18258
See related
AllianceGenome:FB:FBgn0265267
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-SAGE:Wang-051; CT41369; Dmel\CG18258
Summary
Enables serine hydrolase activity. Predicted to be involved in lipid catabolic process. Predicted to be active in extracellular space. Is expressed in adult head and organism. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); familial hyperlipidemia (multiple); obesity; peripheral vascular disease; and type 2 diabetes mellitus. Orthologous to human LIPC (lipase C, hepatic type) and LPL (lipoprotein lipase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
15F3-15F4; 1-57 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (17212307..17213977)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (17106340..17108010)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Alkaline Ceramidase Mediates the Oxidative Stress Response in Drosophila melanogaster Through Sphingosine. Zhang CH, et al. J Insect Sci, 2019 May 1. PMID 31115476, Free PMC Article
  2. Molecular characterization and evolution of a gene family encoding both female- and male-specific reproductive proteins in Drosophila. Sirot LK, et al. Mol Biol Evol, 2014 Jun. PMID 24682282, Free PMC Article
  3. How do Wolbachia modify the Drosophila ovary? New evidences support the "titration-restitution" model for the mechanisms of Wolbachia-induced CI. He Z, et al. BMC Genomics, 2019 Jul 24. PMID 31340757, Free PMC Article
  4. Comparative and functional genomics of lipases in holometabolous insects. Horne I, et al. Insect Biochem Mol Biol, 2009 Aug. PMID 19540341
  5. Single-nucleus transcriptomes reveal evolutionary and functional properties of cell types in the Drosophila accessory gland. Majane AC, et al. Genetics, 2022 Feb 4. PMID 34849871, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables lipase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables lipase activity IEA
Inferred from Electronic Annotation
more info
  
enables serine hydrolase activity HDA PubMed 
enables triglyceride lipase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in lipid catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG18258-PA
anon-SAGE:Wang-051
NP_573201.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    17212307..17213977
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_132973.3 → NP_573201.1  uncharacterized protein Dmel_CG18258 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_573201.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VX70
    Related
    FBpp0074166
    Conserved Domains (1) summary
    cd00707
    Location:172 → 443
    Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VX70 Q9VX70

Gene LinkOut

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