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CG9784 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32629, updated on 11-Apr-2024

Summary

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Official Symbol
CG9784provided by FlyBase
Primary source
FLYBASE:FBgn0030761
Locus tag
Dmel_CG9784
See related
AllianceGenome:FB:FBgn0030761
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG9784; IPP; lincRNA.S9473
Summary
Predicted to enable phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity. Predicted to be involved in inositol phosphate dephosphorylation; phosphatidylinositol dephosphorylation; and positive regulation of flagellated sperm motility. Predicted to be active in several cellular components, including neuronal cell body; non-motile cilium; and ruffle. Is expressed in adult head and organism. Human ortholog(s) of this gene implicated in congenital muscular dystrophy with cataracts and intellectual disability. Orthologous to human INPP5K (inositol polyphosphate-5-phosphatase K). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
14F1-14F2; 1-54 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (16595136..16599215, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (16489169..16493248, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Structural maintenance of chromosomes 3 Neighboring gene Ubiquitin conjugating enzyme 7 Neighboring gene Nucleoporin 153kD Neighboring gene mir-4965 stem loop Neighboring gene mushroom bodies tiny Neighboring gene stable intronic sequence RNA 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A molecular basis for inositol polyphosphate synthesis in Drosophila melanogaster. Seeds AM, et al. J Biol Chem, 2004 Nov 5. PMID 15322119
  2. A Kinome RNAi Screen in Drosophila Identifies Novel Genes Interacting with Lgl, aPKC, and Crb Cell Polarity Genes in Epithelial Tissues. Parsons LM, et al. G3 (Bethesda), 2017 Aug 7. PMID 28611255, Free PMC Article
  3. Presynaptic CK2 promotes synapse organization and stability by targeting Ankyrin2. Bulat V, et al. J Cell Biol, 2014 Jan 6. PMID 24395637, Free PMC Article
  4. Hypoxia controls plasma membrane targeting of polarity proteins by dynamic turnover of PI4P and PI(4,5)P2. Lu J, et al. Elife, 2022 Jun 9. PMID 35678383, Free PMC Article
  5. A conserved myotubularin-related phosphatase regulates autophagy by maintaining autophagic flux. Allen EA, et al. J Cell Biol, 2020 Nov 2. PMID 32915229, Free PMC Article

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in phosphatidylinositol dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphatidylinositol dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in ruffle IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG9784-PA
CG9784-PB
CG9784-PC
NP_001259623.1
NP_001259624.1
NP_573135.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    16595136..16599215 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_132907.3 → NP_573135.1  uncharacterized protein Dmel_CG9784, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_573135.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VXE7
    Related
    FBpp0074064
    Conserved Domains (1) summary
    cd09094
    Location:31 → 341
    INPP5c_INPP5J-like; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of inositol polyphosphate 5-phosphatase J and related proteins

  2. NM_001272695.2 → NP_001259624.1  uncharacterized protein Dmel_CG9784, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259624.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VXE7
    Conserved Domains (1) summary
    cd09094
    Location:31 → 341
    INPP5c_INPP5J-like; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of inositol polyphosphate 5-phosphatase J and related proteins

  3. NM_001272694.2 → NP_001259623.1  uncharacterized protein Dmel_CG9784, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259623.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PHS8
    Conserved Domains (1) summary
    cd09094
    Location:31 → 341
    INPP5c_INPP5J-like; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of inositol polyphosphate 5-phosphatase J and related proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PHS8 M9PHS8
Q9VXE7 Q9VXE7

Gene LinkOut

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