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Pgant5 Polypeptide N-Acetylgalactosaminyltransferase 5 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 326151, updated on 8-Apr-2024

Summary

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Official Symbol
Pgant5provided by FlyBase
Official Full Name
Polypeptide N-Acetylgalactosaminyltransferase 5provided by FlyBase
Primary source
FLYBASE:FBgn0031681
Locus tag
Dmel_CG31651
See related
AllianceGenome:FB:FBgn0031681
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG31651; CG9152; Dmel\CG31651; l(2)e02157; pgant5; PGANT5; pgnat5
Summary
Enables polypeptide N-acetylgalactosaminyltransferase activity. Involved in oligosaccharide biosynthetic process. Located in endomembrane system. Is expressed in several structures, including embryonic/larval digestive system; embryonic/larval posterior spiracle; extended germ band embryo; imaginal disc; and presumptive embryonic/larval digestive system. Orthologous to several human genes including GALNT13 (polypeptide N-acetylgalactosaminyltransferase 13). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
25C4-25C6; 2-15 cM
Exon count:
11
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (5072170..5093592, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (5072170..5093592, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene quick-to-court Neighboring gene antisense RNA:CR45305 Neighboring gene mir-2495 stem loop Neighboring gene Ribosomal protein L37A Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene NADH dehydrogenase (ubiquinone) 13 kDa A subunit

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Conservation of peptide acceptor preferences between Drosophila and mammalian polypeptide-GalNAc transferase ortholog pairs. Gerken TA, et al. Glycobiology, 2008 Nov. PMID 18669915, Free PMC Article
  2. Altered protein glycosylation predicts Alzheimer's disease and modulates its pathology in disease model Drosophila. Frenkel-Pinter M, et al. Neurobiol Aging, 2017 Aug. PMID 28552182
  3. In vivo models of mucin biosynthesis and function. Syed ZA, et al. Adv Drug Deliv Rev, 2022 May. PMID 35278522, Free PMC Article
  4. Insights from Drosophila melanogaster model of Alzheimer's disease. Tue NT, et al. Front Biosci (Landmark Ed), 2020 Jan 1. PMID 31585881
  5. Influence of the quick-to-court gene deletion on courtship behaviour of Drosophila melanogaster. G Belkina E, et al. J Genet, 2021. PMID 34238777

See all (56) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables polypeptide N-acetylgalactosaminyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables polypeptide N-acetylgalactosaminyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in oligosaccharide biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein O-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi stack NAS
Non-traceable Author Statement
more info
 PubMed 
located_in endomembrane system HDA PubMed 

General protein information

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Preferred Names
polypeptide N-Acetylgalactosaminyltransferase 5
Names
CG31651-PA
CG31651-PB
Pgant5-PA
Pgant5-PB
lethal (2) e02157
polypeptide GalNAc transferase 5
NP_001036338.1
NP_608906.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    5072170..5093592 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001042873.2 → NP_001036338.1  polypeptide N-Acetylgalactosaminyltransferase 5, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001036338.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q6WV17
    Conserved Domains (2) summary
    cd02510
    Location:190 → 490
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
    pfam00652
    Location:503 → 619
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

  2. NM_135062.4 → NP_608906.2  polypeptide N-Acetylgalactosaminyltransferase 5, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_608906.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q0E8T2, Q6WV17, Q95T43, Q9VMU3
    Related
    FBpp0078663
    Conserved Domains (2) summary
    cd02510
    Location:190 → 490
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
    pfam00652
    Location:503 → 619
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6WV17.2 Q6WV17

Gene LinkOut

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