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ERp44 Endoplasmic reticulum protein 44 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32588, updated on 4-Apr-2024

Summary

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Official Symbol
ERp44provided by FlyBase
Official Full Name
Endoplasmic reticulum protein 44provided by FlyBase
Primary source
FLYBASE:FBgn0030734
Locus tag
Dmel_CG9911
See related
AllianceGenome:FB:FBgn0030734
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG9911; CG9912; Dmel\CG9911; LD41494p
Summary
Predicted to enable protein disulfide isomerase activity. Located in endomembrane system. Is expressed in adult head and adult heart. Orthologous to human ERP44 (endoplasmic reticulum protein 44). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
14B9-14B9; 1-53 cM
Exon count:
9
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (16293853..16297718, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (16187886..16191751, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Ubiquinol-cytochrome c reductase 14 kDa subunit Neighboring gene cabeza Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45485 Neighboring gene beta Hydroxy acid dehydrogenase 1 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables protein disulfide isomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein disulfide isomerase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in endomembrane system HDA PubMed 
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in endoplasmic reticulum-Golgi intermediate compartment IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
endoplasmic reticulum protein 44
Names
CG9911-PA
CG9911-PB
CG9911-PC
CG9911-PD
ERp44-PA
ERp44-PB
ERp44-PC
ERp44-PD
NP_573111.1
NP_727947.1
NP_727948.1
NP_727949.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    16293853..16297718 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_167495.3 → NP_727948.1  endoplasmic reticulum protein 44, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_727948.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95TL8
    Related
    FBpp0074020
    Conserved Domains (4) summary
    cd02996
    Location:33 → 140
    PDI_a_ERp44; PDIa family, endoplasmic reticulum protein 44 (ERp44) subfamily; ERp44 is an ER-resident protein, induced during stress, involved in thiol-mediated ER retention. It contains an N-terminal TRX domain, similar to that of PDIa, with a CXFS motif followed by ...
    cd03070
    Location:148 → 241
    PDI_b_ERp44; PDIb family, ERp44 subfamily, first redox inactive TRX-like domain b; ERp44 is an endoplasmic reticulum (ER)-resident protein, induced during stress, involved in thiol-mediated ER retention. It contains an N-terminal TRX domain with a CXFS motif followed ...
    cd03072
    Location:252 → 362
    PDI_b'_ERp44; PDIb' family, ERp44 subfamily, second redox inactive TRX-like domain b'; ERp44 is an endoplasmic reticulum (ER)-resident protein, induced during stress, involved in thiol-mediated ER retention. It contains an N-terminal TRX domain with a CXFS motif ...
    pfam13848
    Location:171 → 357
    Thioredoxin_6; Thioredoxin-like domain

  2. NM_167494.3 → NP_727947.1  endoplasmic reticulum protein 44, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_727947.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95TL8
    Related
    FBpp0074021
    Conserved Domains (4) summary
    cd02996
    Location:33 → 140
    PDI_a_ERp44; PDIa family, endoplasmic reticulum protein 44 (ERp44) subfamily; ERp44 is an ER-resident protein, induced during stress, involved in thiol-mediated ER retention. It contains an N-terminal TRX domain, similar to that of PDIa, with a CXFS motif followed by ...
    cd03070
    Location:148 → 241
    PDI_b_ERp44; PDIb family, ERp44 subfamily, first redox inactive TRX-like domain b; ERp44 is an endoplasmic reticulum (ER)-resident protein, induced during stress, involved in thiol-mediated ER retention. It contains an N-terminal TRX domain with a CXFS motif followed ...
    cd03072
    Location:252 → 362
    PDI_b'_ERp44; PDIb' family, ERp44 subfamily, second redox inactive TRX-like domain b'; ERp44 is an endoplasmic reticulum (ER)-resident protein, induced during stress, involved in thiol-mediated ER retention. It contains an N-terminal TRX domain with a CXFS motif ...
    pfam13848
    Location:171 → 357
    Thioredoxin_6; Thioredoxin-like domain

  3. NM_132883.4 → NP_573111.1  endoplasmic reticulum protein 44, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_573111.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95TL8
    Related
    FBpp0074022
    Conserved Domains (4) summary
    cd02996
    Location:33 → 140
    PDI_a_ERp44; PDIa family, endoplasmic reticulum protein 44 (ERp44) subfamily; ERp44 is an ER-resident protein, induced during stress, involved in thiol-mediated ER retention. It contains an N-terminal TRX domain, similar to that of PDIa, with a CXFS motif followed by ...
    cd03070
    Location:148 → 241
    PDI_b_ERp44; PDIb family, ERp44 subfamily, first redox inactive TRX-like domain b; ERp44 is an endoplasmic reticulum (ER)-resident protein, induced during stress, involved in thiol-mediated ER retention. It contains an N-terminal TRX domain with a CXFS motif followed ...
    cd03072
    Location:252 → 362
    PDI_b'_ERp44; PDIb' family, ERp44 subfamily, second redox inactive TRX-like domain b'; ERp44 is an endoplasmic reticulum (ER)-resident protein, induced during stress, involved in thiol-mediated ER retention. It contains an N-terminal TRX domain with a CXFS motif ...
    pfam13848
    Location:171 → 357
    Thioredoxin_6; Thioredoxin-like domain

  4. NM_167496.3 → NP_727949.1  endoplasmic reticulum protein 44, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_727949.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VXI3
    Related
    FBpp0074023
    Conserved Domains (4) summary
    cd02996
    Location:1 → 103
    PDI_a_ERp44; PDIa family, endoplasmic reticulum protein 44 (ERp44) subfamily; ERp44 is an ER-resident protein, induced during stress, involved in thiol-mediated ER retention. It contains an N-terminal TRX domain, similar to that of PDIa, with a CXFS motif followed by ...
    cd03070
    Location:111 → 204
    PDI_b_ERp44; PDIb family, ERp44 subfamily, first redox inactive TRX-like domain b; ERp44 is an endoplasmic reticulum (ER)-resident protein, induced during stress, involved in thiol-mediated ER retention. It contains an N-terminal TRX domain with a CXFS motif followed ...
    cd03072
    Location:215 → 325
    PDI_b'_ERp44; PDIb' family, ERp44 subfamily, second redox inactive TRX-like domain b'; ERp44 is an endoplasmic reticulum (ER)-resident protein, induced during stress, involved in thiol-mediated ER retention. It contains an N-terminal TRX domain with a CXFS motif ...
    pfam13848
    Location:134 → 320
    Thioredoxin_6; Thioredoxin-like domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q95TL8 Q95TL8
Q9VXI3 Q9VXI3

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