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Scamp [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32470, updated on 4-Apr-2024

Summary

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Official Symbol
Scampprovided by FlyBase
Primary source
FLYBASE:FBgn0040285
Locus tag
Dmel_CG9195
See related
AllianceGenome:FB:FBgn0040285
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-EST:fe1F7; BcDNA:GM04934; CG9195; Dmel\CG9195; dmSC; dmSCAMP; Sc; SCAMP
Summary
Involved in long-term memory and neuromuscular synaptic transmission. Located in terminal bouton. Is expressed in adult head; larval ventral nerve cord; and motor neurons. Used to study autism spectrum disorder. Orthologous to several human genes including SCAMP1 (secretory carrier membrane protein 1); SCAMP2 (secretory carrier membrane protein 2); and SCAMP3 (secretory carrier membrane protein 3). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
13C3-13C3; 1-50 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (15446179..15449883, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (15340212..15343916, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Cyclic nucleotide-gated ion channel-like Neighboring gene uncharacterized protein Neighboring gene Adenosylhomocysteinase Neighboring gene shattered

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. De novo SCAMP5 mutation causes a neurodevelopmental disorder with autistic features and seizures. Hubert L, et al. J Med Genet, 2020 Feb. PMID 31439720
  2. Secretory Carrier Membrane Protein (SCAMP) deficiency influences behavior of adult flies. Zheng JC, et al. Front Cell Dev Biol, 2014. PMID 25478561, Free PMC Article
  3. The secretory carrier membrane protein family: structure and membrane topology. Hubbard C, et al. Mol Biol Cell, 2000 Sep. PMID 10982391, Free PMC Article
  4. ben Functions with scamp during synaptic transmission and long-term memory formation in Drosophila. Zhao H, et al. J Neurosci, 2009 Jan 14. PMID 19144841, Free PMC Article
  5. Astrocyte Ca(2+) Influx Negatively Regulates Neuronal Activity. Zhang YV, et al. eNeuro, 2017 Mar-Apr. PMID 28303263, Free PMC Article

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in long-term memory IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in neuromuscular synaptic transmission IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in synaptic vesicle exocytosis ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
located_in axon IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in recycling endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in synaptic vesicle NAS
Non-traceable Author Statement
more info
 PubMed 
located_in terminal bouton IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in trans-Golgi network membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
scamp
Names
CG9195-PA
CG9195-PC
CG9195-PD
Scamp-PA
Scamp-PC
Scamp-PD
anon-fast-evolving-1F7

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    15446179..15449883 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001272643.1 → NP_001259572.1  scamp, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259572.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9NHD7, Q9VXV6
    Conserved Domains (1) summary
    pfam04144
    Location:125 → 301
    SCAMP; SCAMP family

  2. NM_132795.4 → NP_573023.2  scamp, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_573023.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9NHD7, Q9VXV6
    Related
    FBpp0073895
    Conserved Domains (1) summary
    pfam04144
    Location:125 → 301
    SCAMP; SCAMP family

  3. NM_167442.2 → NP_727850.1  scamp, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_727850.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IR34
    Related
    FBpp0304843
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8IR34 Q8IR34
Q95S98 Q95S98
Q9NHD7 Q9NHD7
Q9VXV6 Q9VXV6

Gene LinkOut

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