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fiz fezzik [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32420, updated on 4-Apr-2024

Summary

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Official Symbol
fizprovided by FlyBase
Official Full Name
fezzikprovided by FlyBase
Primary source
FLYBASE:FBgn0030594
Locus tag
Dmel_CG9509
See related
AllianceGenome:FB:FBgn0030594
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG9509; Dm GMCbeta2; Dmel\CG9509
Summary
Predicted to enable ecdysone oxidase activity. Involved in mesoderm development. Is expressed in adult head. Orthologous to human CHDH (choline dehydrogenase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
13A1-13A1; 1-49 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (14906334..14909708, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (14800367..14803741, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Flotillin 2 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Sexual Antagonism, Temporally Fluctuating Selection, and Variable Dominance Affect a Regulatory Polymorphism in Drosophila melanogaster. Glaser-Schmitt A, et al. Mol Biol Evol, 2021 Oct 27. PMID 34289067, Free PMC Article
  2. Adaptive divergence of a transcriptional enhancer between populations of Drosophila melanogaster. Glaser-Schmitt A, et al. Philos Trans R Soc Lond B Biol Sci, 2013 Dec 19. PMID 24218636, Free PMC Article
  3. Selective sweep of a cis-regulatory sequence in a non-African population of Drosophila melanogaster. Saminadin-Peter SS, et al. Mol Biol Evol, 2012 Apr. PMID 22101416
  4. Functional characterization of adaptive variation within a cis-regulatory element influencing Drosophila melanogaster growth. Glaser-Schmitt A, et al. PLoS Biol, 2018 Jan. PMID 29324742, Free PMC Article
  5. Gene expression variation in African and European populations of Drosophila melanogaster. Hutter S, et al. Genome Biol, 2008 Jan 21. PMID 18208589, Free PMC Article

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables flavin adenine dinucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables oxidoreductase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables oxidoreductase activity, acting on CH-OH group of donors IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in ecdysteroid metabolic process IGC
Inferred from Genomic Context
more info
 PubMed 
involved_in ecdysteroid metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in mesoderm development IEP
Inferred from Expression Pattern
more info
 PubMed 

General protein information

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Preferred Names
fezzik
Names
CG9509-PA
CG9509-PB
fiz-PA
fiz-PB
NP_001285254.1
NP_572983.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    14906334..14909708 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001298325.1 → NP_001285254.1  fezzik, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285254.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VY04, T1W1X8
    Conserved Domains (3) summary
    PRK02106
    Location:66 → 621
    PRK02106; choline dehydrogenase; Validated
    pfam05199
    Location:472 → 617
    GMC_oxred_C; GMC oxidoreductase
    cl21454
    Location:142 → 359
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  2. NM_132755.3 → NP_572983.1  fezzik, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_572983.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VY04, T1W1X8
    Related
    FBpp0073795
    Conserved Domains (3) summary
    PRK02106
    Location:66 → 621
    PRK02106; choline dehydrogenase; Validated
    pfam05199
    Location:472 → 617
    GMC_oxred_C; GMC oxidoreductase
    cl21454
    Location:142 → 359
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8MSW2 Q8MSW2
Q9VY04 Q9VY04

Gene LinkOut

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