U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Gpr183 G protein-coupled receptor 183 [ Mus musculus (house mouse) ]

Gene ID: 321019, updated on 21-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Gpr183provided by MGI
Official Full Name
G protein-coupled receptor 183provided by MGI
Primary source
MGI:MGI:2442034
See related
Ensembl:ENSMUSG00000051212 AllianceGenome:MGI:2442034
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ebi2
Summary
Enables oxysterol binding activity. Involved in several processes, including dendritic cell homeostasis; leukocyte chemotaxis; and leukocyte differentiation. Acts upstream of or within leukocyte chemotaxis. Predicted to be located in plasma membrane. Is expressed in several structures, including Peyer's patch; central nervous system; genitourinary system; immune system; and intestine. Orthologous to human GPR183 (G protein-coupled receptor 183). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in spleen adult (RPKM 9.1), mammary gland adult (RPKM 4.9) and 15 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
14 E5; 14 65.86 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (122189743..122202605, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (121952331..121965193, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1810041H14 gene Neighboring gene STARR-positive B cell enhancer ABC_E9906 Neighboring gene STARR-positive B cell enhancer mm9_chr14:122277628-122277929 Neighboring gene STARR-positive B cell enhancer ABC_E11585 Neighboring gene ubiquitin associated domain containing 2 Neighboring gene STARR-positive B cell enhancer mm9_chr14:122306628-122306928 Neighboring gene STARR-positive B cell enhancer mm9_chr14:122309024-122309325 Neighboring gene STARR-positive B cell enhancer ABC_E7358 Neighboring gene STARR-positive B cell enhancer mm9_chr14:122327665-122327966 Neighboring gene STARR-positive B cell enhancer ABC_E8579 Neighboring gene predicted gene, 46485 Neighboring gene STARR-positive B cell enhancer mm9_chr14:122337770-122338071 Neighboring gene G protein-coupled receptor 18 Neighboring gene STARR-positive B cell enhancer mm9_chr14:122364300-122364601 Neighboring gene predicted gene, 52103 Neighboring gene translocase of inner mitochondrial membrane 8A2 Neighboring gene STARR-positive B cell enhancer ABC_E8580 Neighboring gene STARR-positive B cell enhancer ABC_E4126 Neighboring gene STARR-positive B cell enhancer ABC_E4127 Neighboring gene STARR-positive B cell enhancer ABC_E8581 Neighboring gene STARR-positive B cell enhancer ABC_E5466 Neighboring gene RIKEN cDNA A330035P11 gene Neighboring gene STARR-positive B cell enhancer ABC_E5467 Neighboring gene transmembrane 9 superfamily member 2

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. GPR183 Regulates 7α,25-Dihydroxycholesterol-Induced Oxiapoptophagy in L929 Mouse Fibroblast Cell. Kim JS, et al. Molecules, 2022 Jul 27. PMID 35956750, Free PMC Article
  2. Rapid GPR183-mediated recruitment of eosinophils to the lung after Mycobacterium tuberculosis infection. Bohrer AC, et al. Cell Rep, 2022 Jul 26. PMID 35905725, Free PMC Article
  3. A Blunted GPR183/Oxysterol Axis During Dysglycemia Results in Delayed Recruitment of Macrophages to the Lung During Mycobacterium tuberculosis Infection. Ngo MD, et al. J Infect Dis, 2022 Jun 15. PMID 35303091, Free PMC Article
  4. GPR183 Is Dispensable for B1 Cell Accumulation and Function, but Affects B2 Cell Abundance, in the Omentum and Peritoneal Cavity. Barington L, et al. Cells, 2022 Jan 31. PMID 35159303, Free PMC Article
  5. EBI2 regulates pro-inflammatory signalling and cytokine release in astrocytes. Rutkowska A, et al. Neuropharmacology, 2018 May 1. PMID 29374507

See all (64) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Activation of G-protein-coupled receptor 183 initiates inflammatory pain via macrophage CCL22 secretion.
    Title: Activation of G-protein-coupled receptor 183 initiates inflammatory pain via macrophage CCL22 secretion.
  2. The Oxysterol Receptor EBI2 Links Innate and Adaptive Immunity to Limit IFN Response and Systemic Lupus Erythematosus.
    Title: The Oxysterol Receptor EBI2 Links Innate and Adaptive Immunity to Limit IFN Response and Systemic Lupus Erythematosus.
  3. GPR183 Regulates 7alpha,25-Dihydroxycholesterol-Induced Oxiapoptophagy in L929 Mouse Fibroblast Cell.
    Title: GPR183 Regulates 7α,25-Dihydroxycholesterol-Induced Oxiapoptophagy in L929 Mouse Fibroblast Cell.
  4. Rapid GPR183-mediated recruitment of eosinophils to the lung after Mycobacterium tuberculosis infection.
    Title: Rapid GPR183-mediated recruitment of eosinophils to the lung after Mycobacterium tuberculosis infection.
  5. A Blunted GPR183/Oxysterol Axis During Dysglycemia Results in Delayed Recruitment of Macrophages to the Lung During Mycobacterium tuberculosis Infection.
    Title: A Blunted GPR183/Oxysterol Axis During Dysglycemia Results in Delayed Recruitment of Macrophages to the Lung During Mycobacterium tuberculosis Infection.
  6. EBI2 is a negative modulator of brown adipose tissue energy expenditure in mice and human brown adipocytes.
    Title: EBI2 is a negative modulator of brown adipose tissue energy expenditure in mice and human brown adipocytes.
  7. GPR183 Is Dispensable for B1 Cell Accumulation and Function, but Affects B2 Cell Abundance, in the Omentum and Peritoneal Cavity.
    Title: GPR183 Is Dispensable for B1 Cell Accumulation and Function, but Affects B2 Cell Abundance, in the Omentum and Peritoneal Cavity.
  8. GPR183 Regulates Interferons, Autophagy, and Bacterial Growth During Mycobacterium tuberculosis Infection and Is Associated With TB Disease Severity.
    Title: GPR183 Regulates Interferons, Autophagy, and Bacterial Growth During Mycobacterium tuberculosis Infection and Is Associated With TB Disease Severity.
  9. these data implicate the EBI2-oxysterol axis in inflammatory bowel disease pathogenesis
    Title: The EBI2-oxysterol axis promotes the development of intestinal lymphoid structures and colitis.
  10. This study support the hypothesis that EBI2/oxysterol signalling not only controls immune cell function, but may also adjust how astrocytes sense and respond to inflammatory stimuli
    Title: EBI2 regulates pro-inflammatory signalling and cytokine release in astrocytes.
Submit: New GeneRIF Correction See all GeneRIFs (24)

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (10)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables oxysterol binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables oxysterol binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in B cell activation involved in immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in T cell chemotaxis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in T follicular helper cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in adaptive immune response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell chemotaxis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in dendritic cell chemotaxis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in dendritic cell homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in humoral immune response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within leukocyte chemotaxis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in leukocyte chemotaxis ISO
Inferred from Sequence Orthology
more info
  
involved_in mature B cell differentiation involved in immune response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in osteoclast differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of B cell proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of B cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of astrocyte chemotaxis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
G-protein coupled receptor 183
Names
EBV-induced G-protein coupled receptor 2 homolog
Epstein-Barr virus induced gene 2
epstein-Barr virus-induced G-protein coupled receptor 2 homolog

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_183031.2 → NP_898852.2  G-protein coupled receptor 183

    See identical proteins and their annotated locations for NP_898852.2

    Status: VALIDATED

    Source sequence(s)
    AK138693, AK141593, BB525541
    Consensus CDS
    CCDS27343.1
    UniProtKB/Swiss-Prot
    Q3U1F6, Q3U6B2, Q7TMV7, Q80T40
    Related
    ENSMUSP00000052404.8, ENSMUST00000049872.9
    Conserved Domains (1) summary
    cd15159
    Location:28 → 315
    7tmA_EBI2; Epstein-Barr virus (EBV)-induced gene 2, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    122189743..122202605 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036158676.1 → XP_036014569.1  G-protein coupled receptor 183 isoform X1

    UniProtKB/Swiss-Prot
    Q3U1F6, Q3U6B2, Q7TMV7, Q80T40
    Conserved Domains (1) summary
    cd15159
    Location:28 → 315
    7tmA_EBI2; Epstein-Barr virus (EBV)-induced gene 2, member of the class A family of seven-transmembrane G protein-coupled receptors
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3U6B2.1 GenPept UniProtKB/Swiss-Prot:Q3U6B2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous