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Lrrn4 leucine rich repeat neuronal 4 [ Mus musculus (house mouse) ]

Gene ID: 320974, updated on 11-Apr-2024

Summary

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Official Symbol
Lrrn4provided by MGI
Official Full Name
leucine rich repeat neuronal 4provided by MGI
Primary source
MGI:MGI:2445154
See related
Ensembl:ENSMUSG00000043110 AllianceGenome:MGI:2445154
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Nlrr4; B430119L13Rik
Summary
Acts upstream of or within long-term memory and visual learning. Is integral component of plasma membrane. Is expressed in intraembryonic coelom; midgut; reproductive system; and urogenital sinus. Orthologous to human LRRN4 (leucine rich repeat neuronal 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in lung adult (RPKM 11.4), ovary adult (RPKM 9.1) and 15 other tissues See more
Orthologs
human all
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Genomic context

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See Lrrn4 in Genome Data Viewer
Location:
2 F2; 2 64.78 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (132710436..132735930, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (132866686..132894010, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4502 Neighboring gene tRNA methyltransferase 6 Neighboring gene minichromosome maintenance 8 homologous recombination repair factor Neighboring gene STARR-positive B cell enhancer ABC_E10152 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:132672271-132672472 Neighboring gene cardiolipin synthase 1 Neighboring gene predicted gene, 54154 Neighboring gene STARR-positive B cell enhancer ABC_E9534 Neighboring gene fermitin family member 1 Neighboring gene predicted gene 14102 Neighboring gene predicted gene, 25704

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Expression pattern of leucine-rich repeat neuronal protein 4 in adult mouse dorsal root ganglia. Bando T, et al. Neurosci Lett, 2012 Nov 30. PMID 23069668
  2. Neuronal leucine-rich repeat protein 4 functions in hippocampus-dependent long-lasting memory. Bando T, et al. Mol Cell Biol, 2005 May. PMID 15870286, Free PMC Article
  3. Dynamic expression pattern of leucine-rich repeat neuronal protein 4 in the mouse dorsal root ganglia during development. Bando T, et al. Neurosci Lett, 2013 Aug 26. PMID 23701859
  4. Single-cell transcriptomic analysis identifies murine heart molecular features at embryonic and neonatal stages. Feng W, et al. Nat Commun, 2022 Dec 27. PMID 36575170, Free PMC Article
  5. A network of heterochronic genes including Imp1 regulates temporal changes in stem cell properties. Nishino J, et al. Elife, 2013 Nov 5. PMID 24192035, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The spatiotemporal expression pattern of Lrrn4 contributes to the development of synaptic function in the DRG neurons.
    Title: Dynamic expression pattern of leucine-rich repeat neuronal protein 4 in the mouse dorsal root ganglia during development.
  2. Lrrn4 is expressed in a subset of nociceptive neurons and might contribute to the maintenance of nociceptive circuits.
    Title: Expression pattern of leucine-rich repeat neuronal protein 4 in adult mouse dorsal root ganglia.
  3. results suggest that NLRR4 plays a key role in hippocampus-dependent long-lasting memory
    Title: Neuronal leucine-rich repeat protein 4 functions in hippocampus-dependent long-lasting memory.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1)  1 citation
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in long-term memory IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within long-term memory IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within visual learning IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
leucine-rich repeat neuronal protein 4
Names
NLRR-4
neuronal leucine rich repeat-4
neuronal leucine-rich repeat protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_177303.4 → NP_796277.2  leucine-rich repeat neuronal protein 4 precursor

    See identical proteins and their annotated locations for NP_796277.2

    Status: PROVISIONAL

    Source sequence(s)
    AK080889
    Consensus CDS
    CCDS16780.1
    UniProtKB/Swiss-Prot
    A2ANX0, P59383
    UniProtKB/TrEMBL
    Q6EI14
    Related
    ENSMUSP00000057005.3, ENSMUST00000049787.3
    Conserved Domains (5) summary
    COG4886
    Location:63 → 292
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00031
    Location:303 → 315
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:63 → 83
    LRR_RI; leucine-rich repeat [structural motif]
    pfam03326
    Location:347 → 541
    Herpes_TAF50; Herpesvirus transcription activation factor (transactivator)
    pfam00041
    Location:578 → 657
    fn3; Fibronectin type III domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    132710436..132735930 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011239602.3 → XP_011237904.1  leucine-rich repeat neuronal protein 4 isoform X1

    See identical proteins and their annotated locations for XP_011237904.1

    UniProtKB/Swiss-Prot
    A2ANX0, P59383
    UniProtKB/TrEMBL
    Q6EI14
    Conserved Domains (5) summary
    COG4886
    Location:63 → 292
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00031
    Location:303 → 315
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:63 → 83
    LRR_RI; leucine-rich repeat [structural motif]
    pfam03326
    Location:347 → 541
    Herpes_TAF50; Herpesvirus transcription activation factor (transactivator)
    pfam00041
    Location:578 → 657
    fn3; Fibronectin type III domain

  2. XM_030251770.2 → XP_030107630.1  leucine-rich repeat neuronal protein 4 isoform X2

    Conserved Domains (2) summary
    pfam03326
    Location:116 → 310
    Herpes_TAF50; Herpesvirus transcription activation factor (transactivator)
    pfam00041
    Location:347 → 426
    fn3; Fibronectin type III domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P59383.2 GenPept UniProtKB/Swiss-Prot:P59383

Gene LinkOut

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