U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Pisd phosphatidylserine decarboxylase [ Mus musculus (house mouse) ]

Gene ID: 320951, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
Pisdprovided by MGI
Official Full Name
phosphatidylserine decarboxylaseprovided by MGI
Primary source
MGI:MGI:2445114
See related
Ensembl:ENSMUSG00000023452 AllianceGenome:MGI:2445114
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
9030221M09Rik
Summary
Predicted to enable phosphatidylserine decarboxylase activity. Predicted to be involved in mitochondrial protein catabolic process; phosphatidylethanolamine biosynthetic process; and regulation of mitochondrion organization. Predicted to act upstream of or within lipid metabolic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human PISD (phosphatidylserine decarboxylase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in large intestine adult (RPKM 35.1), duodenum adult (RPKM 34.5) and 28 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Pisd in Genome Data Viewer
Location:
5 B1; 5 17.33 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (32893645..32943008, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (32736301..32785642, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_12801 Neighboring gene predicted gene 10461 Neighboring gene YES proto-oncogene 1, Src family tyrosine kinase Neighboring gene STARR-seq mESC enhancer starr_12803 Neighboring gene predicted gene 2420 Neighboring gene predicted gene, 52771 Neighboring gene STARR-seq mESC enhancer starr_12804 Neighboring gene STARR-positive B cell enhancer ABC_E4751 Neighboring gene proline rich 14-like Neighboring gene STARR-positive B cell enhancer ABC_E10312 Neighboring gene ribosomal protein L37 pseudogene Neighboring gene DEP domain containing 5 Neighboring gene predicted gene, 24003

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Phosphatidylserine decarboxylase is critical for the maintenance of skeletal muscle mitochondrial integrity and muscle mass. Selathurai A, et al. Mol Metab, 2019 Sep. PMID 31285171, Free PMC Article
  2. Limited RNA editing in exons of mouse liver and adipose. Lagarrigue S, et al. Genetics, 2013 Apr. PMID 23410828, Free PMC Article
  3. Disruption of the phosphatidylserine decarboxylase gene in mice causes embryonic lethality and mitochondrial defects. Steenbergen R, et al. J Biol Chem, 2005 Dec 2. PMID 16192276, Free PMC Article
  4. Single-cell architecture and functional requirement of alternative splicing during hematopoietic stem cell formation. Wang F, et al. Sci Adv, 2022 Jan 7. PMID 34995116, Free PMC Article
  5. Vesicular monoamine transporter 2 and dopamine transporter are molecular targets of Pitx3 in the ventral midbrain dopamine neurons. Hwang DY, et al. J Neurochem, 2009 Dec. PMID 19780901, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The phosphatidylserine decarboxylase pathway has a significant role in maintaining phospholipid homeostasis in adult skeletal muscle. Moreover, phosphatidylserine decarboxylase is essential for maintenance of mitochondrial integrity and skeletal muscle mass.
    Title: Phosphatidylserine decarboxylase is critical for the maintenance of skeletal muscle mitochondrial integrity and muscle mass.
  2. phosphatidylserine decarboxylase in mice is required for embryonic survival and mitochondria
    Title: Disruption of the phosphatidylserine decarboxylase gene in mice causes embryonic lethality and mitochondrial defects.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (2)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carboxy-lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylserine decarboxylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylserine decarboxylase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in lipid droplet formation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in phosphatidylethanolamine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphatidylethanolamine biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within phospholipid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phospholipid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of mitochondrion organization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in lipid droplet ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
phosphatidylserine decarboxylase proenzyme, mitochondrial
NP_001334261.1
NP_796272.2
XP_006504062.1
XP_006504063.1
XP_006504065.1
XP_030110443.1
XP_030110444.1
XP_030110445.1
XP_030110446.1
XP_030110448.1
XP_036021115.1
XP_036021116.1
XP_036021117.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347332.1 → NP_001334261.1  phosphatidylserine decarboxylase proenzyme, mitochondrial isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC241622
    Consensus CDS
    CCDS84866.1
    UniProtKB/TrEMBL
    E9PX91
    Related
    ENSMUSP00000112573.2, ENSMUST00000120591.8
    Conserved Domains (1) summary
    PLN02938
    Location:70 → 373
    PLN02938; phosphatidylserine decarboxylase

  2. NM_177298.3 → NP_796272.2  phosphatidylserine decarboxylase proenzyme, mitochondrial isoform 1

    See identical proteins and their annotated locations for NP_796272.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    BC070408, CX201846
    Consensus CDS
    CCDS19194.1
    UniProtKB/Swiss-Prot
    Q8BSD6, Q8BSF4
    UniProtKB/TrEMBL
    Q3TRI5, Q505E1
    Related
    ENSMUSP00000051438.10, ENSMUST00000061895.16
    Conserved Domains (1) summary
    cl03656
    Location:148 → 404
    PS_Dcarbxylase; Phosphatidylserine decarboxylase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    32893645..32943008 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036165223.1 → XP_036021116.1  phosphatidylserine decarboxylase proenzyme, mitochondrial isoform X4

    Conserved Domains (1) summary
    PLN02938
    Location:131 → 434
    PLN02938; phosphatidylserine decarboxylase

  2. XM_030254586.1 → XP_030110446.1  phosphatidylserine decarboxylase proenzyme, mitochondrial isoform X5

    UniProtKB/TrEMBL
    Q3TJ76
    Conserved Domains (1) summary
    PLN02938
    Location:3 → 301
    PLN02938; phosphatidylserine decarboxylase

  3. XM_006503999.4 → XP_006504062.1  phosphatidylserine decarboxylase proenzyme, mitochondrial isoform X2

    See identical proteins and their annotated locations for XP_006504062.1

    UniProtKB/TrEMBL
    E9PX91
    Conserved Domains (1) summary
    PLN02938
    Location:70 → 373
    PLN02938; phosphatidylserine decarboxylase

  4. XM_036165222.1 → XP_036021115.1  phosphatidylserine decarboxylase proenzyme, mitochondrial isoform X1

    Conserved Domains (1) summary
    PLN02938
    Location:83 → 386
    PLN02938; phosphatidylserine decarboxylase

  5. XM_030254583.1 → XP_030110443.1  phosphatidylserine decarboxylase proenzyme, mitochondrial isoform X2

    UniProtKB/TrEMBL
    E9PX91
    Conserved Domains (1) summary
    PLN02938
    Location:70 → 373
    PLN02938; phosphatidylserine decarboxylase

  6. XM_006504000.5 → XP_006504063.1  phosphatidylserine decarboxylase proenzyme, mitochondrial isoform X2

    See identical proteins and their annotated locations for XP_006504063.1

    UniProtKB/TrEMBL
    E9PX91
    Conserved Domains (1) summary
    PLN02938
    Location:70 → 373
    PLN02938; phosphatidylserine decarboxylase

  7. XM_030254585.2 → XP_030110445.1  phosphatidylserine decarboxylase proenzyme, mitochondrial isoform X2

    UniProtKB/TrEMBL
    E9PX91
    Conserved Domains (1) summary
    PLN02938
    Location:70 → 373
    PLN02938; phosphatidylserine decarboxylase

  8. XM_030254584.2 → XP_030110444.1  phosphatidylserine decarboxylase proenzyme, mitochondrial isoform X2

    UniProtKB/TrEMBL
    E9PX91
    Conserved Domains (1) summary
    PLN02938
    Location:70 → 373
    PLN02938; phosphatidylserine decarboxylase

  9. XM_030254588.2 → XP_030110448.1  phosphatidylserine decarboxylase proenzyme, mitochondrial isoform X5

    UniProtKB/TrEMBL
    Q3TJ76
    Conserved Domains (1) summary
    PLN02938
    Location:3 → 301
    PLN02938; phosphatidylserine decarboxylase

  10. XM_036165224.1 → XP_036021117.1  phosphatidylserine decarboxylase proenzyme, mitochondrial isoform X5

    UniProtKB/TrEMBL
    Q3TJ76
    Conserved Domains (1) summary
    PLN02938
    Location:3 → 301
    PLN02938; phosphatidylserine decarboxylase

  11. XM_006504002.4 → XP_006504065.1  phosphatidylserine decarboxylase proenzyme, mitochondrial isoform X3

    Conserved Domains (1) summary
    PLN02938
    Location:35 → 338
    PLN02938; phosphatidylserine decarboxylase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BSF4.1 GenPept UniProtKB/Swiss-Prot:Q8BSF4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous