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Spase25 Spase 25-subunit [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32095, updated on 4-Apr-2024

Summary

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Official Symbol
Spase25provided by FlyBase
Official Full Name
Spase 25-subunitprovided by FlyBase
Primary source
FLYBASE:FBgn0030306
Locus tag
Dmel_CG1751
See related
AllianceGenome:FB:FBgn0030306
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG1571; CG1751; Dmel\CG1751
Summary
Predicted to be involved in protein targeting to ER and signal peptide processing. Located in endomembrane system. Is expressed in several structures, including adult heart; dorsal epidermis primordium; embryonic/larval salivary gland; presumptive embryonic/larval system; and proventriculus primordium. Orthologous to human SPCS2 (signal peptidase complex subunit 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
10B15-10B16; 1-34 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (11485250..11486566)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (11379283..11380599)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Cytochrome P450 4g15 Neighboring gene long non-coding RNA:CR44556 Neighboring gene uncharacterized protein Neighboring gene Ubiquitin-like activating enzyme 5 Neighboring gene Death-associated protein kinase related Neighboring gene mir-2492 stem loop

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Analysis of the functions of the signal peptidase complex in the midgut of Tribolium castaneum. Guan J, et al. Arch Insect Biochem Physiol, 2018 Mar. PMID 29265467
  2. Interplay between trauma and Pseudomonas entomophila infection in flies: a central role of the JNK pathway and of CrebA. Ragheb R, et al. Sci Rep, 2017 Nov 24. PMID 29176735, Free PMC Article
  3. A CRISPR screen defines a signal peptide processing pathway required by flaviviruses. Zhang R, et al. Nature, 2016 Jul 7. PMID 27383988, Free PMC Article
  4. Drosophila signal peptidase complex member Spase12 is required for development and cell differentiation. Haase Gilbert E, et al. PLoS One, 2013. PMID 23573290, Free PMC Article
  5. TRAP-seq Profiling and RNAi-Based Genetic Screens Identify Conserved Glial Genes Required for Adult Drosophila Behavior. Ng FS, et al. Front Mol Neurosci, 2016. PMID 28066175, Free PMC Article

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in protein targeting to ER IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal peptide processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal peptide processing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endomembrane system HDA PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
part_of signal peptidase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of signal peptidase complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
spase 25-subunit
Names
CG1751-PA
CG1751-PB
CG1751-PC
SPase 25-subunit
Spase25-PA
Spase25-PB
Spase25-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    11485250..11486566
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001298196.1 → NP_001285125.1  spase 25-subunit, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285125.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VYY2
    UniProtKB/TrEMBL
    B4F5U4, B4F5V0, B4F5V1
    Conserved Domains (1) summary
    pfam06703
    Location:30 → 183
    SPC25; Microsomal signal peptidase 25 kDa subunit (SPC25)

  2. NM_132495.3 → NP_572723.1  spase 25-subunit, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_572723.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VYY2
    UniProtKB/TrEMBL
    B4F5U4, B4F5V0, B4F5V1
    Related
    FBpp0073355
    Conserved Domains (1) summary
    pfam06703
    Location:30 → 183
    SPC25; Microsomal signal peptidase 25 kDa subunit (SPC25)

  3. NM_001298195.1 → NP_001285124.1  spase 25-subunit, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285124.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VYY2
    UniProtKB/TrEMBL
    B4F5U4, B4F5V0, B4F5V1
    Conserved Domains (1) summary
    pfam06703
    Location:30 → 183
    SPC25; Microsomal signal peptidase 25 kDa subunit (SPC25)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B4F5U4 B4F5U4
Q9VYY2.1 Q9VYY2

Gene LinkOut

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