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Spata33 spermatogenesis associated 33 [ Mus musculus (house mouse) ]

Gene ID: 320869, updated on 11-Apr-2024

Summary

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Official Symbol
Spata33provided by MGI
Official Full Name
spermatogenesis associated 33provided by MGI
Primary source
MGI:MGI:2444920
See related
Ensembl:ENSMUSG00000048478 AllianceGenome:MGI:2444920
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4732415M23Rik
Summary
Located in cytoplasm and nucleus. Orthologous to human SPATA33 (spermatogenesis associated 33). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 40.6) and heart adult (RPKM 1.9) See more
Orthologs
human all
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Genomic context

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Location:
8 E1; 8 72.08 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (123939572..123948784)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (123212837..123222045)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene dipeptidase 1 Neighboring gene ribosomal protein S12, pseudogene 9 Neighboring gene charged multivesicular body protein 1A Neighboring gene cyclin dependent kinase 10 Neighboring gene RIKEN cDNA 4933417D19 gene Neighboring gene spermatogenesis associated 2-like Neighboring gene VPS9 domain containing 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. SPATA33 affects the formation of cell adhesion complex by interacting with CTNNA3 in TM4 cells. Zhang Y. Cell Tissue Res, 2022 Jul. PMID 35536443
  2. A novel testis-enriched gene Spata33 is expressed during spermatogenesis. Chen H, et al. PLoS One, 2013. PMID 23844118, Free PMC Article
  3. SPATA33 is an autophagy mediator for cargo selectivity in germline mitophagy. Zhang Y, et al. Cell Death Differ, 2021 Mar. PMID 33087875, Free PMC Article
  4. SPATA33 localizes calcineurin to the mitochondria and regulates sperm motility in mice. Miyata H, et al. Proc Natl Acad Sci U S A, 2021 Aug 31. PMID 34446558, Free PMC Article
  5. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SPATA33 affects the formation of cell adhesion complex by interacting with CTNNA3 in TM4 cells.
    Title: SPATA33 affects the formation of cell adhesion complex by interacting with CTNNA3 in TM4 cells.
  2. SPATA33 is an autophagy mediator for cargo selectivity in germline mitophagy.
    Title: SPATA33 is an autophagy mediator for cargo selectivity in germline mitophagy.
  3. Results indicate that Spata33 was predominantly expressed in the testis and associated with spermatogenesis.
    Title: A novel testis-enriched gene Spata33 is expressed during spermatogenesis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-containing complex binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within autophagy IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within fertilization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within flagellated sperm motility IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within protein localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in male germ cell nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in sperm midpiece IDA
Inferred from Direct Assay
more info
 PubMed 
located_in sperm mitochondrial sheath IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
spermatogenesis-associated protein 33

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_177279.4 → NP_796253.2  spermatogenesis-associated protein 33

    See identical proteins and their annotated locations for NP_796253.2

    Status: VALIDATED

    Source sequence(s)
    AC163617, AK076656
    Consensus CDS
    CCDS40510.1
    UniProtKB/Swiss-Prot
    Q8C624
    Related
    ENSMUSP00000058002.7, ENSMUST00000060133.8
    Conserved Domains (1) summary
    pfam15382
    Location:63 → 130
    DUF4609; Domain of unknown function (DUF4609)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    123939572..123948784
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006531112.3 → XP_006531175.1  spermatogenesis-associated protein 33 isoform X3

  2. XM_011248408.3 → XP_011246710.1  spermatogenesis-associated protein 33 isoform X2

  3. XM_006531111.4 → XP_006531174.1  spermatogenesis-associated protein 33 isoform X1

    UniProtKB/TrEMBL
    A0A1D5RLP4
    Related
    ENSMUSP00000148452.2, ENSMUST00000212161.2

  4. XM_006531113.4 → XP_006531176.1  spermatogenesis-associated protein 33 isoform X4

    UniProtKB/TrEMBL
    A0A1D5RLV5
    Related
    ENSMUSP00000148519.2, ENSMUST00000212346.2
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8C624.1 GenPept UniProtKB/Swiss-Prot:Q8C624

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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