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L3mbtl4 L3MBTL4 histone methyl-lysine binding protein [ Mus musculus (house mouse) ]

Gene ID: 320858, updated on 11-Apr-2024

Summary

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Official Symbol
L3mbtl4provided by MGI
Official Full Name
L3MBTL4 histone methyl-lysine binding proteinprovided by MGI
Primary source
MGI:MGI:2444889
See related
Ensembl:ENSMUSG00000041565 AllianceGenome:MGI:2444889
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
A730037L19Rik; D930040M24Rik
Summary
Predicted to enable chromatin binding activity and histone binding activity. Predicted to be involved in negative regulation of transcription, DNA-templated. Predicted to act upstream of or within chromatin organization. Predicted to be active in nucleus. Orthologous to human L3MBTL4 (L3MBTL histone methyl-lysine binding protein 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
human all
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Genomic context

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Location:
17 E1.2- E1.3; 17 39.3 cM
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (68579893..69091073)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (68272898..68784078)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_43107 Neighboring gene Rho GTPase activating protein 28 Neighboring gene STARR-seq mESC enhancer starr_43108 Neighboring gene STARR-seq mESC enhancer starr_43110 Neighboring gene STARR-seq mESC enhancer starr_43111 Neighboring gene predicted gene, 36252 Neighboring gene predicted gene, 36312 Neighboring gene peroxiredoxin 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_43112 Neighboring gene nucleophosmin 1 pseudogene Neighboring gene transmembrane protein 200C Neighboring gene predicted gene, 38593 Neighboring gene predicted gene, 36392

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A global genomic transcriptional code associated with CNS-expressed genes. Bailey PJ, et al. Exp Cell Res, 2006 Oct 1. PMID 16919269
  2. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559
  3. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
lethal(3)malignant brain tumor-like protein 4
Names
l(3)mbt-like protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_177278.5 → NP_796252.2  lethal(3)malignant brain tumor-like protein 4

    See identical proteins and their annotated locations for NP_796252.2

    Status: VALIDATED

    Source sequence(s)
    AC117803, AC154493, AC191933, AK053068, AK139210, BB548625, CT010483
    UniProtKB/Swiss-Prot
    B1B1A0, B2RVB2, Q8BHZ8
    Conserved Domains (4) summary
    cd09582
    Location:540 → 605
    SAM_Scm-like-3MBT3,4; SAM domain of Scm-like-3MBT3,4 proteins of Polycomb group
    smart00454
    Location:540 → 607
    SAM; Sterile alpha motif
    smart00561
    Location:273 → 364
    MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
    pfam01530
    Location:379 → 405
    zf-C2HC; Zinc finger, C2HC type

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    68579893..69091073
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006524417.3 → XP_006524480.1  lethal(3)malignant brain tumor-like protein 4 isoform X1

    See identical proteins and their annotated locations for XP_006524480.1

    UniProtKB/TrEMBL
    A0A0A0MQK6
    Conserved Domains (3) summary
    cd09582
    Location:531 → 596
    SAM_Scm-like-3MBT3,4; SAM domain of Scm-like-3MBT3,4 proteins of Polycomb group
    smart00561
    Location:273 → 364
    MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
    pfam01530
    Location:379 → 407
    zf-C2HC; Zinc finger, C2HC type

  2. XM_006524416.3 → XP_006524479.1  lethal(3)malignant brain tumor-like protein 4 isoform X1

    See identical proteins and their annotated locations for XP_006524479.1

    UniProtKB/TrEMBL
    A0A0A0MQK6
    Related
    ENSMUSP00000121045.3, ENSMUST00000124543.9
    Conserved Domains (3) summary
    cd09582
    Location:531 → 596
    SAM_Scm-like-3MBT3,4; SAM domain of Scm-like-3MBT3,4 proteins of Polycomb group
    smart00561
    Location:273 → 364
    MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
    pfam01530
    Location:379 → 407
    zf-C2HC; Zinc finger, C2HC type

  3. XM_006524420.2 → XP_006524483.1  lethal(3)malignant brain tumor-like protein 4 isoform X3

    Conserved Domains (4) summary
    cd09582
    Location:376 → 441
    SAM_Scm-like-3MBT3,4; SAM domain of Scm-like-3MBT3,4 proteins of Polycomb group
    smart00561
    Location:118 → 209
    MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
    pfam01530
    Location:224 → 252
    zf-C2HC; Zinc finger, C2HC type
    pfam02820
    Location:42 → 109
    MBT; mbt repeat

  4. XM_036160648.1 → XP_036016541.1  lethal(3)malignant brain tumor-like protein 4 isoform X1

    UniProtKB/TrEMBL
    A0A0A0MQK6
    Conserved Domains (3) summary
    cd09582
    Location:531 → 596
    SAM_Scm-like-3MBT3,4; SAM domain of Scm-like-3MBT3,4 proteins of Polycomb group
    smart00561
    Location:273 → 364
    MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
    pfam01530
    Location:379 → 407
    zf-C2HC; Zinc finger, C2HC type

  5. XM_036160649.1 → XP_036016542.1  lethal(3)malignant brain tumor-like protein 4 isoform X3

    Conserved Domains (4) summary
    cd09582
    Location:376 → 441
    SAM_Scm-like-3MBT3,4; SAM domain of Scm-like-3MBT3,4 proteins of Polycomb group
    smart00561
    Location:118 → 209
    MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
    pfam01530
    Location:224 → 252
    zf-C2HC; Zinc finger, C2HC type
    pfam02820
    Location:42 → 109
    MBT; mbt repeat

  6. XM_017317505.2 → XP_017172994.1  lethal(3)malignant brain tumor-like protein 4 isoform X2

    Conserved Domains (2) summary
    smart00561
    Location:273 → 364
    MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
    pfam01530
    Location:379 → 407
    zf-C2HC; Zinc finger, C2HC type

  7. XM_017317506.2 → XP_017172995.1  lethal(3)malignant brain tumor-like protein 4 isoform X4

    Conserved Domains (2) summary
    smart00561
    Location:273 → 364
    MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
    pfam01530
    Location:379 → 404
    zf-C2HC; Zinc finger, C2HC type

  8. XM_030249846.1 → XP_030105706.1  lethal(3)malignant brain tumor-like protein 4 isoform X6

    Conserved Domains (2) summary
    smart00561
    Location:118 → 209
    MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
    pfam01530
    Location:224 → 252
    zf-C2HC; Zinc finger, C2HC type

  9. XM_030249845.1 → XP_030105705.1  lethal(3)malignant brain tumor-like protein 4 isoform X5

    Conserved Domains (2) summary
    smart00561
    Location:55 → 149
    MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
    cl17705
    Location:273 → 327
    MBT; mbt repeat

  10. XM_011246498.3 → XP_011244800.1  lethal(3)malignant brain tumor-like protein 4 isoform X5

    Related
    ENSMUSP00000117626.2, ENSMUST00000139383.8
    Conserved Domains (2) summary
    smart00561
    Location:55 → 149
    MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
    cl17705
    Location:273 → 327
    MBT; mbt repeat

RNA

  1. XR_004939538.1 RNA Sequence

  2. XR_004939539.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B1B1A0.2 GenPept UniProtKB/Swiss-Prot:B1B1A0

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