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Dpy19l2 dpy-19 like 2 [ Mus musculus (house mouse) ]

Gene ID: 320752, updated on 5-Mar-2024

Summary

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Official Symbol
Dpy19l2provided by MGI
Official Full Name
dpy-19 like 2provided by MGI
Primary source
MGI:MGI:2444662
See related
Ensembl:ENSMUSG00000085576 AllianceGenome:MGI:2444662
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm18376; 4932443J21Rik
Summary
Predicted to enable mannosyltransferase activity. Acts upstream of or within spermatid development. Located in nuclear inner membrane. Is expressed in cerebral cortex. Human ortholog(s) of this gene implicated in spermatogenic failure 9. Orthologous to several human genes including DPY19L2 (dpy-19 like 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis adult (RPKM 21.8) See more
Orthologs
human all
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Genomic context

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Location:
9 A4; 9 10.22 cM
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (24468343..24607752, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (24557047..24696457, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene 10701 Neighboring gene predicted gene, 22380 Neighboring gene dpy-19 like C-mannosyltransferase 1 Neighboring gene predicted gene, 57533 Neighboring gene STARR-seq mESC enhancer starr_23585 Neighboring gene STARR-seq mESC enhancer starr_23586 Neighboring gene cysteine-rich perinuclear theca 4 Neighboring gene STARR-seq mESC enhancer starr_23587 Neighboring gene STARR-seq mESC enhancer starr_23588 Neighboring gene T-box 20 Neighboring gene predicted gene, 29824

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Subcellular localization of phospholipase Cζ in human sperm and its absence in DPY19L2-deficient sperm are consistent with its role in oocyte activation. Escoffier J, et al. Mol Hum Reprod, 2015 Feb. PMID 25354701, Free PMC Article
  2. Dpy19l2-deficient globozoospermic sperm display altered genome packaging and DNA damage that compromises the initiation of embryo development. Yassine S, et al. Mol Hum Reprod, 2015 Feb. PMID 25354700, Free PMC Article
  3. Dynamics of Sun5 localization during spermatogenesis in wild type and Dpy19l2 knock-out mice indicates that Sun5 is not involved in acrosome attachment to the nuclear envelope. Yassine S, et al. PLoS One, 2015. PMID 25775128, Free PMC Article
  4. Absence of Dpy19l2, a new inner nuclear membrane protein, causes globozoospermia in mice by preventing the anchoring of the acrosome to the nucleus. Pierre V, et al. Development, 2012 Aug. PMID 22764053
  5. FAM209 associates with DPY19L2, and is required for sperm acrosome biogenesis and fertility in mice. Castaneda JM, et al. J Cell Sci, 2021 Nov 1. PMID 34471926, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. In Dpy19l2 knock-out round spermatids, the detachment of the acrosome leads to Sun5 and lamin B1 relocalization, confirming that Sun5 protein is excluded from the nuclear envelope facing the acrosome.
    Title: Dynamics of Sun5 localization during spermatogenesis in wild type and Dpy19l2 knock-out mice indicates that Sun5 is not involved in acrosome attachment to the nuclear envelope.
  2. Absence of Dpy19l2 leads to the destabilization of both the nuclear dense lamina and the junction between the acroplaxome and the nuclear envelope in spermatids. Consequently, the acrosome and the manchette fail to be linked to the nucleus.
    Title: Absence of Dpy19l2, a new inner nuclear membrane protein, causes globozoospermia in mice by preventing the anchoring of the acrosome to the nucleus.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables mannosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
involved_in protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spermatid development IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within spermatid development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in spermatid development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within spermatogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in nuclear inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear inner membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
probable C-mannosyltransferase DPY19L2
Names
dpy-19-like protein 2
protein dpy-19 homolog 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001166207.1 → NP_001159679.1  probable C-mannosyltransferase DPY19L2

    See identical proteins and their annotated locations for NP_001159679.1

    Status: VALIDATED

    Source sequence(s)
    AK029497, AK030128, AV254516
    Consensus CDS
    CCDS52743.1
    UniProtKB/Swiss-Prot
    P0CW70
    Related
    ENSMUSP00000132092.2, ENSMUST00000133010.4
    Conserved Domains (1) summary
    pfam10034
    Location:130 → 771
    Dpy19; Q-cell neuroblast polarization

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    24468343..24607752 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006510428.5 → XP_006510491.1  probable C-mannosyltransferase DPY19L2 isoform X2

    Conserved Domains (1) summary
    pfam10034
    Location:130 → 730
    Dpy19; Q-cell neuroblast polarisation

  2. XM_006510427.5 → XP_006510490.1  probable C-mannosyltransferase DPY19L2 isoform X1

    Conserved Domains (1) summary
    pfam10034
    Location:130 → 745
    Dpy19; Q-cell neuroblast polarisation

  3. XM_011242557.3 → XP_011240859.1  probable C-mannosyltransferase DPY19L2 isoform X4

    Conserved Domains (1) summary
    pfam10034
    Location:1 → 502
    Dpy19; Q-cell neuroblast polarisation

  4. XM_030244421.1 → XP_030100281.1  probable C-mannosyltransferase DPY19L2 isoform X5

    Conserved Domains (1) summary
    pfam10034
    Location:4 → 411
    Dpy19; Q-cell neuroblast polarisation

  5. XM_011242556.4 → XP_011240858.1  probable C-mannosyltransferase DPY19L2 isoform X3

    Conserved Domains (1) summary
    pfam10034
    Location:130 → 531
    Dpy19; Q-cell neuroblast polarisation

  6. XM_017313436.2 → XP_017168925.1  probable C-mannosyltransferase DPY19L2 isoform X6

    Conserved Domains (1) summary
    pfam10034
    Location:130 → 378
    Dpy19; Q-cell neuroblast polarisation

RNA

  1. XR_870529.4 RNA Sequence

  2. XR_001778933.3 RNA Sequence

  3. XR_379122.5 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NG_020863.1: Suppressed sequence

    Description
    NG_020863.1: This RefSeq was permanently suppressed because it is now thought that this gene is not a pseudogene.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0CW70.1 GenPept UniProtKB/Swiss-Prot:P0CW70

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