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Vstm4 V-set and transmembrane domain containing 4 [ Mus musculus (house mouse) ]

Gene ID: 320736, updated on 11-Apr-2024

Summary

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Official Symbol
Vstm4provided by MGI
Official Full Name
V-set and transmembrane domain containing 4provided by MGI
Primary source
MGI:MGI:2444633
See related
Ensembl:ENSMUSG00000050666 AllianceGenome:MGI:2444633
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
E130203B14Rik
Summary
Acts upstream of or within several processes, including endothelial cell migration; retina blood vessel maintenance; and vasculature development. Predicted to be located in extracellular region and plasma membrane. Predicted to be integral component of membrane. Orthologous to human VSTM4 (V-set and transmembrane domain containing 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in placenta adult (RPKM 15.0), bladder adult (RPKM 6.8) and 25 other tissues See more
Orthologs
human all
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Genomic context

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Location:
14 B; 14 19.4 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (32578713..32661448)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (32856756..32939491)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 273 Neighboring gene family with sequence similarity 170, member B Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene predicted gene, 36674 Neighboring gene WD repeat and FYVE domain containing 4 Neighboring gene leucine rich repeat containing 18 Neighboring gene STARR-positive B cell enhancer ABC_E4104 Neighboring gene STARR-positive B cell enhancer ABC_E1893 Neighboring gene predicted gene, 25498

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Newly Identified Peptide, Peptide Lv, Promotes Pathological Angiogenesis. Shi L, et al. J Am Heart Assoc, 2019 Nov 19. PMID 31698979, Free PMC Article
  2. Peptide Lv augments L-type voltage-gated calcium channels through vascular endothelial growth factor receptor 2 (VEGFR2) signaling. Shi L, et al. Biochim Biophys Acta, 2015 May. PMID 25698653, Free PMC Article
  3. Expression of the immunoglobulin superfamily cell adhesion molecules in the developing spinal cord and dorsal root ganglion. Gu Z, et al. PLoS One, 2015. PMID 25826454, Free PMC Article
  4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Vascular endothelial growth factor receptor 2 (VEGFR2) interacted with peptide Lv.
    Title: Peptide Lv augments L-type voltage-gated calcium channels through vascular endothelial growth factor receptor 2 (VEGFR2) signaling.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within endothelial cell migration IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within endothelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within retina blood vessel maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within retina vasculature development in camera-type eye IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within sprouting angiogenesis IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within vasodilation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within vasodilation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
V-set and transmembrane domain-containing protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001361602.1 → NP_001348531.1  V-set and transmembrane domain-containing protein 4 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC133585

  2. NM_178791.5 → NP_848906.1  V-set and transmembrane domain-containing protein 4 isoform 1 precursor

    See identical proteins and their annotated locations for NP_848906.1

    Status: VALIDATED

    Source sequence(s)
    AC133585
    Consensus CDS
    CCDS26923.1
    UniProtKB/Swiss-Prot
    T1NXB5
    Related
    ENSMUSP00000055178.6, ENSMUST00000053175.13

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    32578713..32661448
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
T1NXB5.1 GenPept UniProtKB/Swiss-Prot:T1NXB5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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