U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Slc26a9 solute carrier family 26, member 9 [ Mus musculus (house mouse) ]

Gene ID: 320718, updated on 21-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Slc26a9provided by MGI
Official Full Name
solute carrier family 26, member 9provided by MGI
Primary source
MGI:MGI:2444594
See related
Ensembl:ENSMUSG00000042268 AllianceGenome:MGI:2444594
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
E030002L01Rik
Summary
Enables anion:anion antiporter activity and bicarbonate transmembrane transporter activity. Acts upstream of or within bicarbonate transport; chloride transport; and regulation of pH. Located in apical plasma membrane. Is expressed in several structures, including adrenal gland; nervous system; respiratory system; and sensory organ. Orthologous to human SLC26A9 (solute carrier family 26 member 9). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in stomach adult (RPKM 21.9) and lung adult (RPKM 13.8) See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
1 E4; 1 57.18 cM
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (131671760..131699242)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (131744022..131771504)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene RAB7B, member RAS oncogene family Neighboring gene predicted gene, 30104 Neighboring gene STARR-seq mESC enhancer starr_02224 Neighboring gene peptidase M20 domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_02225 Neighboring gene STARR-positive B cell enhancer ABC_E8960 Neighboring gene solute carrier family 41, member 1

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Hydrokinetic pancreatic function and insulin secretion are moduled by Cl(-) uniporter Slc26a9 in mice. Li T, et al. Acta Physiol (Oxf), 2022 Jan. PMID 34525257
  2. Cryo-EM structures and functional characterization of murine Slc26a9 reveal mechanism of uncoupled chloride transport. Walter JD, et al. Elife, 2019 Jul 24. PMID 31339488, Free PMC Article
  3. The chloride channel/transporter Slc26a9 regulates the systemic arterial pressure and renal chloride excretion. Amlal H, et al. J Mol Med (Berl), 2013 May. PMID 23149824
  4. Damage to the gastric epithelium activates cellular bicarbonate secretion via SLC26A9 Cl(-)/HCO(3)(-). Demitrack ES, et al. Am J Physiol Gastrointest Liver Physiol, 2010 Jul. PMID 20413716, Free PMC Article
  5. Slc26a9--anion exchanger, channel and Na+ transporter. Chang MH, et al. J Membr Biol, 2009 Apr. PMID 19365592, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SLC26A9 deficiency causes gastric intraepithelial neoplasia in mice and aggressive gastric cancer in humans.
    Title: SLC26A9 deficiency causes gastric intraepithelial neoplasia in mice and aggressive gastric cancer in humans.
  2. Hydrokinetic pancreatic function and insulin secretion are moduled by Cl(-) uniporter Slc26a9 in mice.
    Title: Hydrokinetic pancreatic function and insulin secretion are moduled by Cl(-) uniporter Slc26a9 in mice.
  3. conformational transitions of Slc26a9, supporting a rapid alternate-access mechanism which mediates uncoupled chloride transport with negligible bicarbonate or sulfate permeability, is reported.
    Title: Cryo-EM structures and functional characterization of murine Slc26a9 reveal mechanism of uncoupled chloride transport.
  4. The chloride channel/transporter Slc26a9 regulates the systemic arterial pressure and renal chloride excretion.
    Title: The chloride channel/transporter Slc26a9 regulates the systemic arterial pressure and renal chloride excretion.
  5. SLC26A9 is activated in airway inflammation. Slc26a9-deficient mice exhibited IL-13-induced airway mucus obstruction. SLC26A9-mediated Cl- secretion is essential for preventing airway obstruction in allergic airway disease.
    Title: SLC26A9-mediated chloride secretion prevents mucus obstruction in airway inflammation.
  6. Cellular HCO(3)(-) secretion, likely through SLC26A9, is the dominant mechanism whereby gastric mucosal surface pH transiently increases in response to photodamage.
    Title: Damage to the gastric epithelium activates cellular bicarbonate secretion via SLC26A9 Cl(-)/HCO(3)(-).
  7. Slc26a9 has three discrete physiological modes: nCl(-)-HCO(3)(-) exchanger, Cl(-) channel, and Na(+)-anion cotransporter.
    Title: Slc26a9--anion exchanger, channel and Na+ transporter.
  8. Slc26a9 plays an essential role in gastric acid secretion via effects on the viability of tubulovesicles/secretory canaliculi and by regulating chloride secretion in parietal cells.
    Title: Deletion of the chloride transporter Slc26a9 causes loss of tubulovesicles in parietal cells and impairs acid secretion in the stomach.
  9. Slc26a9 functions as an electrogenic nCl-/HCO3- exchanger, suggesting a role in pulmonary and gastric HCO3- secretion and/or CO2 transport.
    Title: Physiology of electrogenic SLC26 paralogues.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATPase binding ISO
Inferred from Sequence Orthology
more info
  
enables bicarbonate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables bicarbonate transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables chloride channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables chloride channel activity ISO
Inferred from Sequence Orthology
more info
  
enables chloride transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chloride:bicarbonate antiporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables oxalate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables solute:inorganic anion antiporter activity ISO
Inferred from Sequence Orthology
more info
  
enables sulfate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within bicarbonate transport IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within chloride transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in chloride transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within chloride transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in chloride transport ISO
Inferred from Sequence Orthology
more info
  
involved_in monoatomic anion transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in monoatomic anion transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of pH IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
  
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in endosome membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
solute carrier family 26 member 9
Names
SLC26A9 anion transporter/exchanger
anion transporter/exchanger protein 9
anion transporter/exchanger-9

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_177243.4 → NP_796217.2  solute carrier family 26 member 9

    See identical proteins and their annotated locations for NP_796217.2

    Status: VALIDATED

    Source sequence(s)
    AK078966, AK086815
    Consensus CDS
    CCDS15273.1
    UniProtKB/Swiss-Prot
    Q8BU91, Q8BVC3
    UniProtKB/TrEMBL
    A0A0R4J0F7
    Related
    ENSMUSP00000036916.4, ENSMUST00000049027.10
    Conserved Domains (1) summary
    TIGR00815
    Location:57 → 733
    sulP; high affinity sulphate transporter 1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    131671760..131699242
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006529700.2 → XP_006529763.1  solute carrier family 26 member 9 isoform X1

    See identical proteins and their annotated locations for XP_006529763.1

    UniProtKB/Swiss-Prot
    Q8BU91, Q8BVC3
    UniProtKB/TrEMBL
    A0A0R4J0F7
    Conserved Domains (1) summary
    TIGR00815
    Location:57 → 733
    sulP; high affinity sulphate transporter 1

  2. XM_030254980.1 → XP_030110840.1  solute carrier family 26 member 9 isoform X2

    Conserved Domains (1) summary
    TIGR00815
    Location:7 → 457
    sulP; high affinity sulphate transporter 1

  3. XM_006529701.1 → XP_006529764.1  solute carrier family 26 member 9 isoform X2

    Conserved Domains (1) summary
    TIGR00815
    Location:7 → 457
    sulP; high affinity sulphate transporter 1

RNA

  1. XR_387176.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BU91.1 GenPept UniProtKB/Swiss-Prot:Q8BU91

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous