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Cyb5r2 cytochrome b5 reductase 2 [ Mus musculus (house mouse) ]

Gene ID: 320635, updated on 5-Mar-2024

Summary

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Official Symbol
Cyb5r2provided by MGI
Official Full Name
cytochrome b5 reductase 2provided by MGI
Primary source
MGI:MGI:2444415
See related
Ensembl:ENSMUSG00000048065 AllianceGenome:MGI:2444415
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
b5R.2; D630003K02Rik
Summary
Predicted to enable FAD binding activity and cytochrome-b5 reductase activity, acting on NAD(P)H. Predicted to act upstream of or within sterol biosynthetic process. Located in mitochondrion. Orthologous to human CYB5R2 (cytochrome b5 reductase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 2.5), genital fat pad adult (RPKM 1.9) and 6 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 E3; 7 57.21 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (107347653..107357407, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (107748446..107758202, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene synaptotagmin IX Neighboring gene STARR-seq mESC enhancer starr_19764 Neighboring gene STARR-positive B cell enhancer ABC_E8198 Neighboring gene olfactomedin-like 1 Neighboring gene STARR-positive B cell enhancer ABC_E1352 Neighboring gene STARR-seq mESC enhancer starr_19765 Neighboring gene PTPRF interacting protein, binding protein 2 (liprin beta 2) Neighboring gene STARR-seq mESC enhancer starr_19766 Neighboring gene STARR-positive B cell enhancer mm9_chr7:114807884-114808185 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:114846576-114846777 Neighboring gene STARR-seq mESC enhancer starr_19769 Neighboring gene STARR-seq mESC enhancer starr_19770 Neighboring gene ovochymase 2 Neighboring gene olfactory receptor family 5 subfamily P member 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mitochondrial diaphorases as NAD⁺ donors to segments of the citric acid cycle that support substrate-level phosphorylation yielding ATP during respiratory inhibition. Kiss G, et al. FASEB J, 2014 Apr. PMID 24391134, Free PMC Article
  2. ¹H NMR metabolic profiling of plasma reveals additional phenotypes in knockout mouse models. Probert F, et al. J Proteome Res, 2015 May 1. PMID 25849460
  3. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
  4. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC130177, MGC130178

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables FAD binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cytochrome-b5 reductase activity, acting on NAD(P)H ISO
Inferred from Sequence Orthology
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within steroid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within steroid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within sterol biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
NADH-cytochrome b5 reductase 2
Names
cytochrome b5 reductase b5R.2
NP_001192156.1
NP_796190.1
XP_006508011.1
XP_017177792.1
XP_017177793.1
XP_017177794.1
XP_030098539.1
XP_036009061.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001205227.1 → NP_001192156.1  NADH-cytochrome b5 reductase 2 isoform 1

    See identical proteins and their annotated locations for NP_001192156.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK147952, AL513346
    Consensus CDS
    CCDS57579.1
    UniProtKB/Swiss-Prot
    Q3KNK3
    Related
    ENSMUSP00000050061.8, ENSMUST00000052438.8
    Conserved Domains (2) summary
    cd06183
    Location:20 → 292
    cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...
    PTZ00319
    Location:13 → 292
    PTZ00319; NADH-cytochrome B5 reductase; Provisional

  2. NM_177216.4 → NP_796190.1  NADH-cytochrome b5 reductase 2 isoform 2

    See identical proteins and their annotated locations for NP_796190.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AK085272, AK147952, AL513346
    Consensus CDS
    CCDS85373.1
    UniProtKB/Swiss-Prot
    Q3KNK3, Q3UGG1, Q8BUG7
    Related
    ENSMUSP00000146504.2, ENSMUST00000208217.2
    Conserved Domains (1) summary
    PLN02252
    Location:13 → 276
    PLN02252; nitrate reductase [NADPH]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    107347653..107357407 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017322303.3 → XP_017177792.1  NADH-cytochrome b5 reductase 2 isoform X1

    Conserved Domains (1) summary
    PLN02252
    Location:25 → 271
    PLN02252; nitrate reductase [NADPH]

  2. XM_036153168.1 → XP_036009061.1  NADH-cytochrome b5 reductase 2 isoform X4

    Conserved Domains (1) summary
    PLN02252
    Location:13 → 220
    PLN02252; nitrate reductase [NADPH]

  3. XM_006507948.5 → XP_006508011.1  NADH-cytochrome b5 reductase 2 isoform X2

    Conserved Domains (1) summary
    PLN02252
    Location:25 → 299
    PLN02252; nitrate reductase [NADPH]

  4. XM_017322304.3 → XP_017177793.1  NADH-cytochrome b5 reductase 2 isoform X3

    UniProtKB/Swiss-Prot
    Q3KNK3, Q3UGG1, Q8BUG7
    Conserved Domains (1) summary
    PLN02252
    Location:13 → 276
    PLN02252; nitrate reductase [NADPH]

  5. XM_030242679.2 → XP_030098539.1  NADH-cytochrome b5 reductase 2 isoform X5

    Conserved Domains (1) summary
    cd06183
    Location:1 → 175
    cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...

  6. XM_017322305.3 → XP_017177794.1  NADH-cytochrome b5 reductase 2 isoform X3

    UniProtKB/Swiss-Prot
    Q3KNK3, Q3UGG1, Q8BUG7
    Conserved Domains (1) summary
    PLN02252
    Location:13 → 276
    PLN02252; nitrate reductase [NADPH]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3KNK3.2 GenPept UniProtKB/Swiss-Prot:Q3KNK3

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