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Snrnp200 small nuclear ribonucleoprotein 200 (U5) [ Mus musculus (house mouse) ]

Gene ID: 320632, updated on 21-Apr-2024

Summary

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Official Symbol
Snrnp200provided by MGI
Official Full Name
small nuclear ribonucleoprotein 200 (U5)provided by MGI
Primary source
MGI:MGI:2444401
See related
Ensembl:ENSMUSG00000003660 AllianceGenome:MGI:2444401
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
HELIC2; Ascc3l1; U5-200KD; U5-200-KD; A330064G03Rik
Summary
On February 19, 2002, this locus was switched from human to mouse. The source accession, Z70200.1, is almost identical to the mouse BAC clone AC074224, and it matches the mouse cDNA accession BC011390 as well. The human gene is LocusID 23020. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in thymus adult (RPKM 28.4), CNS E11.5 (RPKM 26.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 F1; 2 61.84 cM
Exon count:
45
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (127050306..127082373)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (127208386..127240453)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene inositol 1,4,5-triphosphate receptor interacting protein-like 1 Neighboring gene STARR-positive B cell enhancer ABC_E8792 Neighboring gene STARR-seq mESC enhancer starr_05621 Neighboring gene RIKEN cDNA 1810024B03 gene Neighboring gene STARR-positive B cell enhancer ABC_E3401 Neighboring gene STARR-positive B cell enhancer ABC_E642 Neighboring gene cytosolic iron-sulfur protein assembly 1 Neighboring gene transmembrane protein 127

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The HeLa 200 kDa U5 snRNP-specific protein and its homologue in Saccharomyces cerevisiae are members of the DEXH-box protein family of putative RNA helicases. Lauber J, et al. EMBO J, 1996 Aug 1. PMID 8670905, Free PMC Article
  2. Comparative sequence analysis of a single-gene conserved segment in mouse and human. Thomas JW, et al. Mamm Genome, 2003 Oct. PMID 14694903
  3. Systematic identification of factors for provirus silencing in embryonic stem cells. Yang BX, et al. Cell, 2015 Sep 24. PMID 26365490, Free PMC Article
  4. Methyltransferase-like 21e inhibits 26S proteasome activity to facilitate hypertrophy of type IIb myofibers. Wang C, et al. FASEB J, 2019 Aug. PMID 31162944, Free PMC Article
  5. A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain. McKee AE, et al. BMC Dev Biol, 2005 Jul 20. PMID 16033648, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Transgenic (1) 
  • Targeted (2) 
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0788

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA helicase activity ISO
Inferred from Sequence Orthology
more info
  
enables helicase activity ISO
Inferred from Sequence Orthology
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within RNA splicing IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
  
involved_in spliceosome conformational change to release U4 (or U4atac) and U1 (or U11) IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spliceosome conformational change to release U4 (or U4atac) and U1 (or U11) ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of U2-type catalytic step 1 spliceosome ISO
Inferred from Sequence Orthology
more info
  
part_of U2-type precatalytic spliceosome ISO
Inferred from Sequence Orthology
more info
  
part_of U4/U6 x U5 tri-snRNP complex ISO
Inferred from Sequence Orthology
more info
  
part_of U5 snRNP ISO
Inferred from Sequence Orthology
more info
  
part_of catalytic step 2 spliceosome ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  
part_of spliceosomal complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of spliceosomal complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
U5 small nuclear ribonucleoprotein 200 kDa helicase
Names
BRR2 homolog
U5 snRNP-specific protein, 200 kDa (DEXH RNA helicase family)
activating signal cointegrator 1 complex subunit 3-like 1
NP_796188.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_177214.5 → NP_796188.2  U5 small nuclear ribonucleoprotein 200 kDa helicase

    See identical proteins and their annotated locations for NP_796188.2

    Status: VALIDATED

    Source sequence(s)
    AL845368
    Consensus CDS
    CCDS16695.1
    UniProtKB/Swiss-Prot
    Q69ZZ3, Q6P4T2
    Related
    ENSMUSP00000099509.4, ENSMUST00000103220.4
    Conserved Domains (7) summary
    smart00490
    Location:1616 → 1694
    HELICc; helicase superfamily c-terminal domain
    smart00487
    Location:1320 → 1508
    DEXDc; DEAD-like helicases superfamily
    smart00611
    Location:1809 → 2125
    SEC63; Domain of unknown function in Sec63p, Brr2p and other proteins
    COG1204
    Location:452 → 1241
    BRR2; Replicative superfamily II helicase [Replication, recombination and repair]
    cd00079
    Location:684 → 870
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    pfam00270
    Location:1329 → 1500
    DEAD; DEAD/DEAH box helicase
    pfam02889
    Location:982 → 1285
    Sec63; Sec63 Brl domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    127050306..127082373
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6P4T2.1 GenPept UniProtKB/Swiss-Prot:Q6P4T2

Gene LinkOut

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