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Lmod3 leiomodin 3 (fetal) [ Mus musculus (house mouse) ]

Gene ID: 320502, updated on 9-Dec-2024

Summary

Official Symbol
Lmod3provided by MGI
Official Full Name
leiomodin 3 (fetal)provided by MGI
Primary source
MGI:MGI:2444169
See related
Ensembl:ENSMUSG00000044086 AllianceGenome:MGI:2444169
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
5430424A14Rik
Summary
Predicted to enable actin monomer binding activity and tropomyosin binding activity. Involved in skeletal muscle fiber development. Located in A band. Is expressed in several structures, including ganglia; limb segment; lung; sensory organ; and skeletal musculature. Used to study nemaline myopathy 10. Human ortholog(s) of this gene implicated in nemaline myopathy 10. Orthologous to human LMOD3 (leiomodin 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in heart adult (RPKM 11.2), limb E14.5 (RPKM 3.2) and 1 other tissue See more
Orthologs
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Genomic context

See Lmod3 in Genome Data Viewer
Location:
6 D3; 6 44.92 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (97215491..97230137, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (97238530..97253217, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2796 Neighboring gene STARR-seq mESC enhancer starr_16779 Neighboring gene STARR-positive B cell enhancer ABC_E1324 Neighboring gene STARR-seq mESC enhancer starr_16780 Neighboring gene ubiquitin-like modifier activating enzyme 3 Neighboring gene ADP-ribosylation factor-like 6 interacting protein 5 Neighboring gene predicted gene, 32191 Neighboring gene STARR-seq mESC enhancer starr_16782 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:97271123-97271316 Neighboring gene FERM domain containing 4B Neighboring gene STARR-seq mESC enhancer starr_16786 Neighboring gene STARR-seq mESC enhancer starr_16788 Neighboring gene STARR-seq mESC enhancer starr_16791 Neighboring gene uncharacterized protein C3orf38 homolog Neighboring gene STARR-seq mESC enhancer starr_16793 Neighboring gene STARR-seq mESC enhancer starr_16794 Neighboring gene STARR-seq mESC enhancer starr_16795 Neighboring gene predicted gene, 46970

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

General gene information

Clone Names

  • MGC156399

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin monomer binding  
enables actin monomer binding  
enables protein binding PubMed 
enables tropomyosin binding  
enables tropomyosin binding  
enables tropomyosin binding  
Process Evidence Code Pubs
involved_in actin filament organization  
involved_in actin nucleation  
involved_in actin nucleation  
involved_in muscle contraction  
involved_in myofibril assembly  
involved_in pointed-end actin filament capping  
involved_in positive regulation of skeletal muscle fiber development  
involved_in positive regulation of skeletal muscle fiber development  
involved_in skeletal muscle fiber development PubMed 
involved_in skeletal muscle thin filament assembly  
involved_in skeletal muscle thin filament assembly  
involved_in striated muscle contraction  
involved_in striated muscle contraction  
Component Evidence Code Pubs
located_in A band PubMed 
located_in M band  
located_in M band  
located_in cytoplasm  
is_active_in cytoskeleton  
is_active_in myofibril  
is_active_in striated muscle thin filament  
located_in striated muscle thin filament  
located_in striated muscle thin filament  

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081157.2NP_001074626.1  leiomodin-3

    See identical proteins and their annotated locations for NP_001074626.1

    Status: VALIDATED

    Source sequence(s)
    AC155724
    Consensus CDS
    CCDS39576.1
    UniProtKB/Swiss-Prot
    A0AUN8, A0JP45, E9QA62
    Related
    ENSMUSP00000093315.3, ENSMUST00000095655.4
    Conserved Domains (2) summary
    pfam03250
    Location:1674
    Tropomodulin
    cl39015
    Location:195355
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    97215491..97230137 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006506270.5XP_006506333.1  leiomodin-3 isoform X1

    See identical proteins and their annotated locations for XP_006506333.1

    UniProtKB/Swiss-Prot
    A0AUN8, A0JP45, E9QA62
    Conserved Domains (2) summary
    pfam03250
    Location:1674
    Tropomodulin
    cl39015
    Location:195355
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
  2. XM_006506271.5XP_006506334.1  leiomodin-3 isoform X1

    See identical proteins and their annotated locations for XP_006506334.1

    UniProtKB/Swiss-Prot
    A0AUN8, A0JP45, E9QA62
    Conserved Domains (2) summary
    pfam03250
    Location:1674
    Tropomodulin
    cl39015
    Location:195355
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
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