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Ipcef1 interaction protein for cytohesin exchange factors 1 [ Mus musculus (house mouse) ]

Gene ID: 320495, updated on 5-Mar-2024

Summary

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Official Symbol
Ipcef1provided by MGI
Official Full Name
interaction protein for cytohesin exchange factors 1provided by MGI
Primary source
MGI:MGI:2444159
See related
Ensembl:ENSMUSG00000064065 AllianceGenome:MGI:2444159
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
A130090K04Rik
Summary
Predicted to enable protein domain specific binding activity. Predicted to be located in cytosol and plasma membrane. Orthologous to human IPCEF1 (interaction protein for cytohesin exchange factors 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cortex adult (RPKM 7.0), frontal lobe adult (RPKM 6.9) and 8 other tissues See more
Orthologs
human all
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Genomic context

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See Ipcef1 in Genome Data Viewer
Location:
10 A1; 10 1.85 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (6835779..6973185, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (6885779..7054782, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_25585 Neighboring gene STARR-seq mESC enhancer starr_25584 Neighboring gene predicted gene 3213 Neighboring gene STARR-seq mESC enhancer starr_25583 Neighboring gene STARR-seq mESC enhancer starr_25582 Neighboring gene STARR-seq mESC enhancer starr_25581 Neighboring gene tripartite motif-containing 59 pseudogene Neighboring gene STARR-seq mESC enhancer starr_25580 Neighboring gene opioid receptor, mu 1 Neighboring gene STARR-seq mESC enhancer starr_25578 Neighboring gene STARR-positive B cell enhancer ABC_E9781 Neighboring gene STARR-positive B cell enhancer ABC_E11427 Neighboring gene STARR-seq mESC enhancer starr_25577 Neighboring gene STARR-seq mESC enhancer starr_25576 Neighboring gene Cnksr family member 3 Neighboring gene predicted gene, 53610

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Toll-like receptor 2 induces pathogenicity in Th17 cells and reveals a role for IPCEF in regulating Th17 cell migration. Marks KE, et al. Cell Rep, 2021 Jun 29. PMID 34192530, Free PMC Article
  2. Molecular networks involved in mouse cerebral corticogenesis and spatio-temporal regulation of Sox4 and Sox11 novel antisense transcripts revealed by transcriptome profiling. Ling KH, et al. Genome Biol, 2009. PMID 19799774, Free PMC Article
  3. Mtu1-Mediated Thiouridine Formation of Mitochondrial tRNAs Is Required for Mitochondrial Translation and Is Involved in Reversible Infantile Liver Injury. Wu Y, et al. PLoS Genet, 2016 Sep. PMID 27689697, Free PMC Article
  4. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
  5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Toll-like receptor 2 induces pathogenicity in Th17 cells and reveals a role for IPCEF in regulating Th17 cell migration.
    Title: Toll-like receptor 2 induces pathogenicity in Th17 cells and reveals a role for IPCEF in regulating Th17 cell migration.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
interactor protein for cytohesin exchange factors 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033391.2 → NP_001028563.1  interactor protein for cytohesin exchange factors 1 isoform 4

    See identical proteins and their annotated locations for NP_001028563.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) represents use of an alternate promoter, 5' UTR, and 5' coding region, and uses an alternate 3' splice pattern, compared to variant 1. The resulting isoform (4) differs at the N- and C-termini and is shorter than isoform 1.
    Source sequence(s)
    AK135851
    Consensus CDS
    CCDS56689.1
    UniProtKB/TrEMBL
    Q3UX69
    Related
    ENSMUSP00000128131.2, ENSMUST00000170680.8
    Conserved Domains (3) summary
    pfam00169
    Location:7 → 60
    PH; PH domain
    pfam15310
    Location:67 → 143
    VAD1-2; Vitamin A-deficiency (VAD) rat model signalling
    cl17171
    Location:7 → 68
    PH-like; Pleckstrin homology-like domain

  2. NM_001170800.1 → NP_001164271.1  interactor protein for cytohesin exchange factors 1 isoform 1

    See identical proteins and their annotated locations for NP_001164271.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AC155718, AC164171
    Consensus CDS
    CCDS56688.1
    UniProtKB/Swiss-Prot
    Q3TZY2, Q5DU31, Q8CAP9
    Related
    ENSMUSP00000101242.2, ENSMUST00000105617.8
    Conserved Domains (2) summary
    cd01260
    Location:2 → 115
    PH_CNK_mammalian-like; Connector enhancer of KSR (Kinase suppressor of ras) (CNK) pleckstrin homology (PH) domain
    pfam11928
    Location:140 → 190
    DUF3446; Domain of unknown function (DUF3446)

  3. NM_001170801.1 → NP_001164272.1  interactor protein for cytohesin exchange factors 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site and an alternate 3' splice pattern, compared to variant 1. The resulting isoform (2) includes an additional 4-aa segment and has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC155718, AC164171
    Related
    ENSMUST00000154998.8
    Conserved Domains (3) summary
    cd01260
    Location:2 → 115
    PH_CNK_mammalian-like; Connector enhancer of KSR (Kinase suppressor of ras) (CNK) pleckstrin homology (PH) domain
    pfam00169
    Location:16 → 107
    PH; PH domain
    pfam15310
    Location:114 → 194
    VAD1-2; Vitamin A-deficiency (VAD) rat model signalling

  4. NM_001170802.1 → NP_001164273.1  interactor protein for cytohesin exchange factors 1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate 3' splice pattern, compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC155718, AC164171
    Related
    ENSMUST00000144622.8
    Conserved Domains (3) summary
    cd01260
    Location:2 → 115
    PH_CNK_mammalian-like; Connector enhancer of KSR (Kinase suppressor of ras) (CNK) pleckstrin homology (PH) domain
    pfam00169
    Location:16 → 107
    PH; PH domain
    pfam15310
    Location:114 → 190
    VAD1-2; Vitamin A-deficiency (VAD) rat model signalling

  5. NM_001347225.1 → NP_001334154.1  interactor protein for cytohesin exchange factors 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AA472059, AK038257, AK038911, AK135851, BQ176089, CK781068
    Consensus CDS
    CCDS83676.1
    UniProtKB/Swiss-Prot
    Q5DU31
    UniProtKB/TrEMBL
    Q3UX69
    Related
    ENSMUSP00000077215.4, ENSMUST00000078070.10
    Conserved Domains (1) summary
    cd01260
    Location:2 → 115
    PH_CNK_mammalian-like; Connector enhancer of KSR (Kinase suppressor of ras) (CNK) pleckstrin homology (PH) domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    6835779..6973185 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011243081.1 → XP_011241383.1  interactor protein for cytohesin exchange factors 1 isoform X2

    Conserved Domains (1) summary
    cd01260
    Location:24 → 137
    PH_CNK_mammalian-like; Connector enhancer of KSR (Kinase suppressor of ras) (CNK) pleckstrin homology (PH) domain

  2. XM_011243082.3 → XP_011241384.1  interactor protein for cytohesin exchange factors 1 isoform X3

    Conserved Domains (1) summary
    cd01260
    Location:25 → 138
    PH_CNK_mammalian-like; Connector enhancer of KSR (Kinase suppressor of ras) (CNK) pleckstrin homology (PH) domain

  3. XM_011243080.3 → XP_011241382.1  interactor protein for cytohesin exchange factors 1 isoform X1

    Conserved Domains (1) summary
    cd01260
    Location:25 → 138
    PH_CNK_mammalian-like; Connector enhancer of KSR (Kinase suppressor of ras) (CNK) pleckstrin homology (PH) domain

  4. XM_030245126.2 → XP_030100986.1  interactor protein for cytohesin exchange factors 1 isoform X4

    Conserved Domains (1) summary
    cd01260
    Location:2 → 115
    PH_CNK_mammalian-like; Connector enhancer of KSR (Kinase suppressor of ras) (CNK) pleckstrin homology (PH) domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5DU31.2 GenPept UniProtKB/Swiss-Prot:Q5DU31

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