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Ppm1e protein phosphatase 1E (PP2C domain containing) [ Mus musculus (house mouse) ]

Gene ID: 320472, updated on 5-Mar-2024

Summary

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Official Symbol
Ppm1eprovided by MGI
Official Full Name
protein phosphatase 1E (PP2C domain containing)provided by MGI
Primary source
MGI:MGI:2444096
See related
Ensembl:ENSMUSG00000046442 AllianceGenome:MGI:2444096
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
POPX1; PP2CH; mKIAA1072; B930008A12Rik
Summary
Predicted to enable protein serine/threonine phosphatase activity. Involved in protein dephosphorylation. Predicted to be located in mitochondrion; nucleolus; and nucleoplasm. Predicted to be part of protein-containing complex. Predicted to be active in nucleus. Is expressed in central nervous system and retina. Orthologous to human PPM1E (protein phosphatase, Mg2+/Mn2+ dependent 1E). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in frontal lobe adult (RPKM 37.0), CNS E18 (RPKM 18.9) and 7 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 C; 11 51.99 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (87117724..87249884, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (87226906..87358994, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E26 Neighboring gene proline rich 11 Neighboring gene microRNA 301 Neighboring gene spindle and kinetochore associated complex subunit 2 Neighboring gene STARR-seq mESC enhancer starr_30287 Neighboring gene tripartite motif-containing 37 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:87059058-87059211 Neighboring gene predicted gene, 33937 Neighboring gene predicted gene, 22883 Neighboring gene STARR-positive B cell enhancer ABC_E3005 Neighboring gene RAD51 paralog C Neighboring gene VISTA enhancer mm264 Neighboring gene testis expressed gene 14 intercellular bridge forming factor Neighboring gene U1a1 small nuclear RNA

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. N-Myristoylation is essential for protein phosphatases PPM1A and PPM1B to dephosphorylate their physiological substrates in cells. Chida T, et al. Biochem J, 2013 Feb 1. PMID 23088624
  2. Osteoblast-specific expression of Panx3 is dispensable for postnatal bone remodeling. Yorgan TA, et al. Bone, 2019 Oct. PMID 31202927
  3. Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling. Wilkinson B, et al. Sci Rep, 2017 Jul 13. PMID 28706196, Free PMC Article
  4. RNA binding proteins co-localize with small tau inclusions in tauopathy. Maziuk BF, et al. Acta Neuropathol Commun, 2018 Aug 1. PMID 30068389, Free PMC Article
  5. Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Feb 28. PMID 12693553

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cation binding IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables myosin phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cellular response to lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to xenobiotic stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in peptidyl-threonine dephosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of stress fiber assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in protein dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein dephosphorylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protein phosphatase 1E
Names
ca(2+)/calmodulin-dependent protein kinase phosphatase N
caMKN
caMKP-N
caMKP-nucleus
partner of PIX 1
partner of PIX-alpha
partner of PIXA
NP_796141.2
XP_036012659.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_177167.4 → NP_796141.2  protein phosphatase 1E

    See identical proteins and their annotated locations for NP_796141.2

    Status: VALIDATED

    Source sequence(s)
    AL596130
    Consensus CDS
    CCDS25211.1
    UniProtKB/Swiss-Prot
    Q5SX30, Q80TL0, Q8BGM6, Q8CB81
    UniProtKB/TrEMBL
    B2KGP3
    Related
    ENSMUSP00000061278.5, ENSMUST00000055438.5
    Conserved Domains (1) summary
    cd00143
    Location:227 → 485
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    87117724..87249884 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036156766.1 → XP_036012659.1  protein phosphatase 1E isoform X1

    Conserved Domains (1) summary
    cd00143
    Location:233 → 422
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80TL0.2 GenPept UniProtKB/Swiss-Prot:Q80TL0

Gene LinkOut

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