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P4ha3 procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide III [ Mus musculus (house mouse) ]

Gene ID: 320452, updated on 11-Apr-2024

Summary

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Official Symbol
P4ha3provided by MGI
Official Full Name
procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide IIIprovided by MGI
Primary source
MGI:MGI:2444049
See related
Ensembl:ENSMUSG00000051048 AllianceGenome:MGI:2444049
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D930031A02Rik
Summary
Predicted to enable procollagen-proline 4-dioxygenase activity. Predicted to be involved in peptidyl-proline hydroxylation to 4-hydroxy-L-proline. Predicted to be active in endoplasmic reticulum. Is expressed in several structures, including central nervous system; ear; genitourinary system; respiratory system; and skeleton. Orthologous to human P4HA3 (prolyl 4-hydroxylase subunit alpha 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in limb E14.5 (RPKM 12.1), CNS E14 (RPKM 3.2) and 11 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 E2; 7 54.34 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (99934637..99968908)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (100285489..100319701)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 34877 Neighboring gene phosphoglucomutase 2-like 1 Neighboring gene STARR-seq mESC enhancer starr_19666 Neighboring gene glutathione peroxidase 2, pseudogene 1 Neighboring gene STARR-positive B cell enhancer ABC_E4953 Neighboring gene protein phosphatase methylesterase 1 Neighboring gene STARR-positive B cell enhancer ABC_E2243 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:107520817-107520926 Neighboring gene C2 calcium-dependent domain containing 3 Neighboring gene STARR-seq mESC enhancer starr_19668 Neighboring gene predicted gene 10603

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identification and characterization of a third human, rat, and mouse collagen prolyl 4-hydroxylase isoenzyme. Kukkola L, et al. J Biol Chem, 2003 Nov 28. PMID 14500733
  2. Deletion of the T-box transcription factor gene, Tbx1, in mice induces differential expression of genes associated with cleft palate in humans. Funato N, et al. Arch Oral Biol, 2018 Nov. PMID 30121012
  3. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
  4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. analysis of collagen prolyl 4-hydroxylase isoenzyme 3, its expression and catalytic properties
    Title: Identification and characterization of a third human, rat, and mouse collagen prolyl 4-hydroxylase isoenzyme.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (1) 

General gene information

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Homology

Clone Names

  • MGC99449

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables L-ascorbic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables dioxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
Inferred from Electronic Annotation
more info
  
enables procollagen-proline 4-dioxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables procollagen-proline 4-dioxygenase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in peptidyl-proline hydroxylation to 4-hydroxy-L-proline IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
prolyl 4-hydroxylase subunit alpha-3
Names
4-PH alpha-3
collagen prolyl 4-hydroxylase alpha 3
procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-3
NP_796135.3
XP_006508007.1
XP_036009059.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_177161.4 → NP_796135.3  prolyl 4-hydroxylase subunit alpha-3 precursor

    Status: VALIDATED

    Source sequence(s)
    AC122269
    Consensus CDS
    CCDS21496.1
    UniProtKB/Swiss-Prot
    Q640R2, Q6W3F0, Q8C3A6
    UniProtKB/TrEMBL
    H7BX23
    Related
    ENSMUSP00000055297.6, ENSMUST00000057023.12
    Conserved Domains (2) summary
    smart00702
    Location:354 → 526
    P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
    pfam08336
    Location:31 → 157
    P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    99934637..99968908
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006507944.5 → XP_006508007.1  prolyl 4-hydroxylase subunit alpha-3 isoform X1

    UniProtKB/Swiss-Prot
    Q640R2, Q6W3F0, Q8C3A6
    Conserved Domains (2) summary
    smart00702
    Location:363 → 535
    P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
    pfam08336
    Location:31 → 157
    P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region

  2. XM_036153166.1 → XP_036009059.1  prolyl 4-hydroxylase subunit alpha-3 isoform X2

    Conserved Domains (1) summary
    pfam08336
    Location:32 → 106
    P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region

RNA

  1. XR_004934118.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6W3F0.1 GenPept UniProtKB/Swiss-Prot:Q6W3F0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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