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Alg6 ALG6 alpha-1,3-glucosyltransferase [ Mus musculus (house mouse) ]

Gene ID: 320438, updated on 11-Apr-2024

Summary

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Official Symbol
Alg6provided by MGI
Official Full Name
ALG6 alpha-1,3-glucosyltransferaseprovided by MGI
Primary source
MGI:MGI:2444031
See related
Ensembl:ENSMUSG00000073792 AllianceGenome:MGI:2444031
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
E230028F23Rik
Summary
Predicted to enable dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity. Predicted to be involved in oligosaccharide-lipid intermediate biosynthetic process and protein N-linked glycosylation. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be integral component of membrane. Predicted to be active in endoplasmic reticulum membrane. Is expressed in metanephros. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Ic. Orthologous to human ALG6 (ALG6 alpha-1,3-glucosyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in limb E14.5 (RPKM 4.7), placenta adult (RPKM 4.6) and 26 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 C6; 4 45.71 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (99603833..99651697)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (99715596..99763460)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene non-SMC element 1 homolog pseudogene Neighboring gene STARR-seq mESC enhancer starr_10869 Neighboring gene STARR-seq mESC enhancer starr_10871 Neighboring gene STARR-seq mESC enhancer starr_10873 Neighboring gene forkhead box D3 Neighboring gene STARR-positive B cell enhancer ABC_E6192 Neighboring gene STARR-seq mESC enhancer starr_10875 Neighboring gene integrin beta 3 binding protein (beta3-endonexin) Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:99495752-99496005 Neighboring gene EF-hand calcium binding domain 7 Neighboring gene predicted gene, 26425

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Systems biology approach to identify transcriptome reprogramming and candidate microRNA targets during the progression of polycystic kidney disease. Pandey P, et al. BMC Syst Biol, 2011 Apr 25. PMID 21518438, Free PMC Article
  2. Functional genomic landscape of cancer-intrinsic evasion of killing by T cells. Lawson KA, et al. Nature, 2020 Oct. PMID 32968282, Free PMC Article
  3. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
  4. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
  5. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glucosyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables hexosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in oligosaccharide-lipid intermediate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein N-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein N-linked glycosylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase
Names
asparagine-linked glycosylation 6 (alpha-1,3,-glucosyltransferase)
asparagine-linked glycosylation 6 homolog (yeast, alpha-1,3,-glucosyltransferase)
asparagine-linked glycosylation protein 6 homolog
dol-P-Glc:Man(9)GlcNAc(2)-PP-Dol alpha-1,3-glucosyltransferase
dolichyl-P-Glc:Man9GlcNAc2-PP-dolichyl glucosyltransferase
NP_001074733.1
XP_006503218.1
XP_006503219.1
XP_006503221.1
XP_006503223.1
XP_006503224.1
XP_006503225.1
XP_006503226.1
XP_006503227.1
XP_017175746.1
XP_030109465.1
XP_036020078.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081264.1 → NP_001074733.1  dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase precursor

    See identical proteins and their annotated locations for NP_001074733.1

    Status: VALIDATED

    Source sequence(s)
    BX005053
    Consensus CDS
    CCDS38818.1
    UniProtKB/Swiss-Prot
    Q3TAE8, Q3TZF4
    Related
    ENSMUSP00000095574.3, ENSMUST00000097961.9
    Conserved Domains (1) summary
    pfam03155
    Location:32 → 487
    Alg6_Alg8; ALG6, ALG8 glycosyltransferase family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    99603833..99651697
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006503158.2 → XP_006503221.1  dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase isoform X3

    Conserved Domains (1) summary
    pfam03155
    Location:32 → 333
    Alg6_Alg8; ALG6, ALG8 glycosyltransferase family

  2. XM_006503161.2 → XP_006503224.1  dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase isoform X5

    Conserved Domains (1) summary
    cl21590
    Location:32 → 346
    PMT_2; Dolichyl-phosphate-mannose-protein mannosyltransferase

  3. XM_036164185.1 → XP_036020078.1  dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase isoform X6

    Conserved Domains (1) summary
    pfam03155
    Location:32 → 351
    Alg6_Alg8; ALG6, ALG8 glycosyltransferase family

  4. XM_017320257.1 → XP_017175746.1  dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase isoform X8

    Conserved Domains (1) summary
    cl21590
    Location:12 → 268
    PMT_2; Dolichyl-phosphate-mannose-protein mannosyltransferase

  5. XM_030253605.1 → XP_030109465.1  dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase isoform X4

    Conserved Domains (1) summary
    pfam03155
    Location:7 → 357
    Alg6_Alg8; ALG6, ALG8 glycosyltransferase family

  6. XM_006503155.1 → XP_006503218.1  dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase isoform X1

    Conserved Domains (1) summary
    pfam03155
    Location:32 → 457
    Alg6_Alg8; ALG6, ALG8 glycosyltransferase family

  7. XM_006503156.1 → XP_006503219.1  dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase isoform X2

    Conserved Domains (1) summary
    pfam03155
    Location:13 → 390
    Alg6_Alg8; ALG6, ALG8 glycosyltransferase family

  8. XM_006503162.1 → XP_006503225.1  dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase isoform X7

    Conserved Domains (1) summary
    cl21590
    Location:60 → 316
    PMT_2; Dolichyl-phosphate-mannose-protein mannosyltransferase

  9. XM_006503164.1 → XP_006503227.1  dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase isoform X9

    Conserved Domains (1) summary
    cl21590
    Location:47 → 242
    PMT_2; Dolichyl-phosphate-mannose-protein mannosyltransferase

  10. XM_006503160.1 → XP_006503223.1  dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase isoform X4

    See identical proteins and their annotated locations for XP_006503223.1

    Conserved Domains (1) summary
    pfam03155
    Location:7 → 357
    Alg6_Alg8; ALG6, ALG8 glycosyltransferase family

  11. XM_006503163.5 → XP_006503226.1  dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase isoform X8

    Conserved Domains (1) summary
    cl21590
    Location:12 → 268
    PMT_2; Dolichyl-phosphate-mannose-protein mannosyltransferase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3TAE8.1 GenPept UniProtKB/Swiss-Prot:Q3TAE8

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