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Rinl Ras and Rab interactor-like [ Mus musculus (house mouse) ]

Gene ID: 320435, updated on 5-Apr-2024

Summary

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Official Symbol
Rinlprovided by MGI
Official Full Name
Ras and Rab interactor-likeprovided by MGI
Primary source
MGI:MGI:2444024
See related
Ensembl:ENSMUSG00000051735 AllianceGenome:MGI:2444024
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
5830482F20Rik; 9930116N10Rik
Summary
Enables guanyl-nucleotide exchange factor activity. Acts upstream of or within endocytosis. Located in actin cytoskeleton and ruffle. Orthologous to human RINL (Ras and Rab interactor like). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in thymus adult (RPKM 20.1), spleen adult (RPKM 12.7) and 11 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 B1; 7 16.93 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (28488186..28498390)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (28788874..28798965)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene coiled-coil glutamate-rich protein 2 Neighboring gene nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, beta Neighboring gene STARR-positive B cell enhancer ABC_E128 Neighboring gene sirtuin 2 Neighboring gene predicted gene, 19897 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:29565175-29565376 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:29565964-29566190 Neighboring gene STARR-positive B cell enhancer ABC_E6528 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:29577451-29577634 Neighboring gene nuclear encoded tRNA lysine 24 (anticodon TTT) Neighboring gene STARR-seq mESC enhancer starr_18438 Neighboring gene STARR-positive B cell enhancer ABC_E156 Neighboring gene STARR-positive B cell enhancer ABC_E8158 Neighboring gene heterogeneous nuclear ribonucleoprotein L Neighboring gene STARR-seq mESC enhancer starr_18440 Neighboring gene enoyl coenzyme A hydratase 1, peroxisomal

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Rin-like, a novel regulator of endocytosis, acts as guanine nucleotide exchange factor for Rab5a and Rab22. Woller B, et al. Biochim Biophys Acta, 2011 Jun. PMID 21419809, Free PMC Article
  2. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  3. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 

General gene information

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Homology

Clone Names

  • MGC51433

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables guanyl-nucleotide exchange factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables small GTPase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within endocytosis IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in actin cytoskeleton IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in endocytic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in ruffle IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
ras and Rab interactor-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001358916.1 → NP_001345845.1  ras and Rab interactor-like protein

    Status: VALIDATED

    Source sequence(s)
    AC171210
    Consensus CDS
    CCDS21056.1
    UniProtKB/Swiss-Prot
    Q3TRU0, Q80UW3, Q811H9, Q8BUR6, Q8C0J1
    Related
    ENSMUSP00000146576.2, ENSMUST00000209035.2
    Conserved Domains (2) summary
    pfam02204
    Location:412 → 514
    VPS9; Vacuolar sorting protein 9 (VPS9) domain
    cl15255
    Location:43 → 136
    SH2; Src homology 2 (SH2) domain

  2. NM_177158.5 → NP_796132.2  ras and Rab interactor-like protein

    See identical proteins and their annotated locations for NP_796132.2

    Status: VALIDATED

    Source sequence(s)
    AC171210, AK030993, AK162469, BF147913
    Consensus CDS
    CCDS21056.1
    UniProtKB/Swiss-Prot
    Q3TRU0, Q80UW3, Q811H9, Q8BUR6, Q8C0J1
    Related
    ENSMUSP00000058447.8, ENSMUST00000059857.8
    Conserved Domains (2) summary
    pfam02204
    Location:412 → 514
    VPS9; Vacuolar sorting protein 9 (VPS9) domain
    cl15255
    Location:43 → 136
    SH2; Src homology 2 (SH2) domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    28488186..28498390
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006540098.5 → XP_006540161.3  ras and Rab interactor-like protein isoform X1

    Conserved Domains (2) summary
    pfam02204
    Location:416 → 518
    VPS9; Vacuolar sorting protein 9 (VPS9) domain
    cl15255
    Location:96 → 189
    SH2; Src homology 2 (SH2) domain

  2. XM_006540099.1 → XP_006540162.1  ras and Rab interactor-like protein isoform X2

    See identical proteins and their annotated locations for XP_006540162.1

    UniProtKB/Swiss-Prot
    Q3TRU0, Q80UW3, Q811H9, Q8BUR6, Q8C0J1
    Conserved Domains (2) summary
    pfam02204
    Location:412 → 514
    VPS9; Vacuolar sorting protein 9 (VPS9) domain
    cl15255
    Location:43 → 136
    SH2; Src homology 2 (SH2) domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80UW3.1 GenPept UniProtKB/Swiss-Prot:Q80UW3

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