Lrig3 leucine-rich repeats and immunoglobulin-like domains 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Lrig3provided by MGI
Official Full Name: leucine-rich repeats and immunoglobulin-like domains 3provided by MGI
Primary source: MGI:MGI:2443955
See related: Ensembl:ENSMUSG00000020105 AllianceGenome:MGI:2443955
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mKIAA3016; 9030421L11Rik; 9130004I02Rik; 9430095K15Rik
Summary: Acts upstream of or within otolith morphogenesis. Predicted to be located in cytoplasmic vesicle and plasma membrane. Predicted to be integral component of membrane. Is expressed in several structures, including branchial arch; central nervous system; embryo mesenchyme; pancreas tip epithelium; and sensory organ. Orthologous to human LRIG3 (leucine rich repeats and immunoglobulin like domains 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in limb E14.5 (RPKM 28.5), colon adult (RPKM 21.1) and 17 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 D3; 10 73.66 cM

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (125802088..125851228)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (125966219..126015359)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Lrig1 and Lrig3 cooperate to control Ret receptor signaling, sensory axonal growth and epidermal innervation.
Title: Lrig1 and Lrig3 cooperate to control Ret receptor signaling, sensory axonal growth and epidermal innervation.
These findings in mice complement the human epidemiological results and suggest that Lrig3 may influence heart function and plasma lipid levels in mice and humans.
Title: Cardiac hypertrophy and decreased high-density lipoprotein cholesterol in Lrig3-deficient mice.
Lrig1 and Lrig3 overlap prominently in the developing vestibular apparatus and simultaneous removal of both genes disrupts inner ear morphogenesis.
Title: In vivo analysis of Lrig genes reveals redundant and independent functions in the inner ear.
Results suggest that although both Lrig1 and Lrig3 can interact with ErbB receptors in vitro, modulation of Neuregulin signaling is unlikely to contribute to Lrig3-dependent processes of inner ear morphogenesis.
Title: Vertebrate Lrig3-ErbB interactions occur in vitro but are unlikely to play a role in Lrig3-dependent inner ear morphogenesis.
mutually antagonistic interactions between Lrig3 and Ntn1 create complementary expression domains that define the future shape of the lateral canal. Removal of one copy of Ntn1 from Lrig3 mutants rescues the circling behavior and the canal malformation.
Title: Cross-repressive interactions between Lrig3 and netrin 1 shape the architecture of the inner ear.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Gene trapped (1) 1 citation
Targeted (6) 1 citation

General gene information

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Markers

BE116579 (e-PCR)
- UniSTS:248505

Lrig3 (e-PCR), detects polymorphism
- UniSTS:525256

D10Mit270 (e-PCR), detects polymorphism
- UniSTS:126174

Lrig3 (e-PCR), detects polymorphism
- UniSTS:525552

Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
involved_in otolith morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within otolith morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: leucine-rich repeats and immunoglobulin-like domains protein 3

Names: LIG-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_177152.5 → NP_796126.4 leucine-rich repeats and immunoglobulin-like domains protein 3 precursor

See identical proteins and their annotated locations for NP_796126.4

Status: VALIDATED

Source sequence(s)

AC153489, AK035166, BC065142

Consensus CDS

CCDS24219.1

UniProtKB/Swiss-Prot

Q6P1C6, Q6ZPE6, Q8BRF0, Q8BS51, Q8C5E4

Related

ENSMUSP00000074360.7, ENSMUST00000074807.8

Conserved Domains (9) summary

cd05763
Location:620 → 694

Ig_1; Subgroup of the immunoglobulin (Ig) superfamily

smart00408
Location:711 → 774

IGc2; Immunoglobulin C-2 Type

smart00082
Location:446 → 494

LRRCT; Leucine rich repeat C-terminal domain

cd00116
Location:81 → 324

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

pfam07679
Location:603 → 693

I-set; Immunoglobulin I-set domain

sd00031
Location:76 → 99

LRR_1; leucine-rich repeat [structural motif]

sd00033
Location:147 → 168

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:312 → 371

LRR_8; Leucine rich repeat

cl11960
Location:500 → 587

Ig; Immunoglobulin domain