Cenpt centromere protein T [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cenptprovided by MGI
Official Full Name: centromere protein Tprovided by MGI
Primary source: MGI:MGI:2443939
See related: Ensembl:ENSMUSG00000036672 AllianceGenome:MGI:2443939
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: G630055P03Rik
Summary: Predicted to enable DNA binding activity and protein heterodimerization activity. Predicted to be involved in chromosome segregation; kinetochore assembly; and mitotic cell cycle. Predicted to act upstream of or within cell division. Predicted to be located in kinetochore and nuclear body. Is expressed in several structures, including adrenal gland; genitourinary system; liver; retina; and spleen. Orthologous to human CENPT (centromere protein T). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E14 (RPKM 19.8), limb E14.5 (RPKM 19.1) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 D3; 8 53.05 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (106571297..106581678, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (105844669..105855086, complement)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CENP-T regulates both the G2/M transition and anaphase entry by acting through CDH1 in meiotic oocytes.
Title: CENP-T regulates both the G2/M transition and anaphase entry by acting through CDH1 in meiotic oocytes.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables protein heterodimerization activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell division	IEA Inferred from Electronic Annotation more info
involved_in chromosome organization	ISO Inferred from Sequence Orthology more info
involved_in chromosome segregation	IBA Inferred from Biological aspect of Ancestor more info
involved_in chromosome segregation	ISO Inferred from Sequence Orthology more info
involved_in chromosome segregation	NAS Non-traceable Author Statement more info	PubMed
involved_in kinetochore assembly	ISO Inferred from Sequence Orthology more info
involved_in mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic cell cycle	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in chromosome, centromeric region	ISO Inferred from Sequence Orthology more info
part_of inner kinetochore	ISO Inferred from Sequence Orthology more info
located_in kinetochore	ISO Inferred from Sequence Orthology more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: centromere protein T

Names: CENP-T

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_177150.2 → NP_796124.1 centromere protein T

See identical proteins and their annotated locations for NP_796124.1

Status: PROVISIONAL

Source sequence(s)

AK090340

Consensus CDS

CCDS22615.1

UniProtKB/Swiss-Prot

Q3TJM4, Q3TPY6, Q3UPD2, Q8BTH0, Q8BTP2, Q8R5E9

Related

ENSMUSP00000038188.5, ENSMUST00000040776.6

Conserved Domains (2) summary

pfam16171
Location:1 → 374

CENP-T_N; Centromere kinetochore component CENP-T N-terminus

cl23735
Location:411 → 507

H4; Histone H4, one of the four histones, along with H2A, H2B and H3, which forms the eukaryotic nucleosome core; along with H3, it plays a central role in nucleosome formation; histones bind to DNA and wrap the genetic material into "beads on a string" in ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

106571297..106581678 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006531107.5 → XP_006531170.1 centromere protein T isoform X4

See identical proteins and their annotated locations for XP_006531170.1

Conserved Domains (2) summary

pfam16171
Location:1 → 270

CENP-T_N; Centromere kinetochore component CENP-T N-terminus

cl23735
Location:326 → 422

H4; Histone H4, one of the four histones, along with H2A, H2B and H3, which forms the eukaryotic nucleosome core; along with H3, it plays a central role in nucleosome formation; histones bind to DNA and wrap the genetic material into "beads on a string" in ...
XM_030243618.2 → XP_030099478.1 centromere protein T isoform X5

Conserved Domains (2) summary

pfam16171
Location:1 → 270

CENP-T_N; Centromere kinetochore component CENP-T N-terminus

cl23735
Location:307 → 403

H4; Histone H4, one of the four histones, along with H2A, H2B and H3, which forms the eukaryotic nucleosome core; along with H3, it plays a central role in nucleosome formation; histones bind to DNA and wrap the genetic material into "beads on a string" in ...
XM_017312860.3 → XP_017168349.1 centromere protein T isoform X3

Conserved Domains (2) summary

pfam16171
Location:12 → 349

CENP-T_N; Centromere kinetochore component CENP-T N-terminus

cl23735
Location:405 → 501

H4; Histone H4, one of the four histones, along with H2A, H2B and H3, which forms the eukaryotic nucleosome core; along with H3, it plays a central role in nucleosome formation; histones bind to DNA and wrap the genetic material into "beads on a string" in ...
XM_006531108.3 → XP_006531171.1 centromere protein T isoform X4

See identical proteins and their annotated locations for XP_006531171.1

Conserved Domains (2) summary

pfam16171
Location:1 → 270

CENP-T_N; Centromere kinetochore component CENP-T N-terminus

cl23735
Location:326 → 422

H4; Histone H4, one of the four histones, along with H2A, H2B and H3, which forms the eukaryotic nucleosome core; along with H3, it plays a central role in nucleosome formation; histones bind to DNA and wrap the genetic material into "beads on a string" in ...
XM_030243617.2 → XP_030099477.1 centromere protein T isoform X5

Conserved Domains (2) summary

pfam16171
Location:1 → 270

CENP-T_N; Centromere kinetochore component CENP-T N-terminus

cl23735
Location:307 → 403

H4; Histone H4, one of the four histones, along with H2A, H2B and H3, which forms the eukaryotic nucleosome core; along with H3, it plays a central role in nucleosome formation; histones bind to DNA and wrap the genetic material into "beads on a string" in ...
XM_036154102.1 → XP_036009995.1 centromere protein T isoform X5

Conserved Domains (2) summary

pfam16171
Location:1 → 270

CENP-T_N; Centromere kinetochore component CENP-T N-terminus

cl23735
Location:307 → 403

H4; Histone H4, one of the four histones, along with H2A, H2B and H3, which forms the eukaryotic nucleosome core; along with H3, it plays a central role in nucleosome formation; histones bind to DNA and wrap the genetic material into "beads on a string" in ...
XM_036154100.1 → XP_036009993.1 centromere protein T isoform X4

Conserved Domains (2) summary

pfam16171
Location:1 → 270

CENP-T_N; Centromere kinetochore component CENP-T N-terminus

cl23735
Location:326 → 422

H4; Histone H4, one of the four histones, along with H2A, H2B and H3, which forms the eukaryotic nucleosome core; along with H3, it plays a central role in nucleosome formation; histones bind to DNA and wrap the genetic material into "beads on a string" in ...
XM_030243619.2 → XP_030099479.1 centromere protein T isoform X6

Conserved Domains (2) summary

pfam16171
Location:1 → 123

CENP-T_N; Centromere kinetochore component CENP-T N-terminus

cl23735
Location:160 → 256

H4; Histone H4, one of the four histones, along with H2A, H2B and H3, which forms the eukaryotic nucleosome core; along with H3, it plays a central role in nucleosome formation; histones bind to DNA and wrap the genetic material into "beads on a string" in ...
XM_011248407.3 → XP_011246709.1 centromere protein T isoform X2

See identical proteins and their annotated locations for XP_011246709.1

UniProtKB/Swiss-Prot

Q3TJM4, Q3TPY6, Q3UPD2, Q8BTH0, Q8BTP2, Q8R5E9

Conserved Domains (2) summary

pfam16171
Location:1 → 374

CENP-T_N; Centromere kinetochore component CENP-T N-terminus

cl23735
Location:411 → 507

H4; Histone H4, one of the four histones, along with H2A, H2B and H3, which forms the eukaryotic nucleosome core; along with H3, it plays a central role in nucleosome formation; histones bind to DNA and wrap the genetic material into "beads on a string" in ...
XM_006531104.4 → XP_006531167.1 centromere protein T isoform X1

Conserved Domains (2) summary

pfam16171
Location:1 → 374

CENP-T_N; Centromere kinetochore component CENP-T N-terminus

cl23735
Location:430 → 526

H4; Histone H4, one of the four histones, along with H2A, H2B and H3, which forms the eukaryotic nucleosome core; along with H3, it plays a central role in nucleosome formation; histones bind to DNA and wrap the genetic material into "beads on a string" in ...