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Scai suppressor of cancer cell invasion [ Mus musculus (house mouse) ]

Gene ID: 320271, updated on 3-Apr-2024

Summary

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Official Symbol
Scaiprovided by MGI
Official Full Name
suppressor of cancer cell invasionprovided by MGI
Primary source
MGI:MGI:2443716
See related
Ensembl:ENSMUSG00000035236 AllianceGenome:MGI:2443716
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
9330112M16; A930041I02Rik
Summary
Enables transcription corepressor activity. Involved in negative regulation of Rho protein signal transduction and negative regulation of cell migration. Located in cytoplasm and nucleus. Is expressed in olfactory epithelium. Orthologous to human SCAI (suppressor of cancer cell invasion). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E18 (RPKM 4.6), limb E14.5 (RPKM 4.6) and 20 other tissues See more
Orthologs
human all
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Genomic context

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See Scai in Genome Data Viewer
Location:
2 B; 2 24.42 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (38956226..39080770, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (39066214..39190758, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5911 Neighboring gene STARR-positive B cell enhancer ABC_E4447 Neighboring gene STARR-positive B cell enhancer mm9_chr2:38866813-38867114 Neighboring gene actin related protein 2/3 complex, subunit 5-like Neighboring gene golgin A1 Neighboring gene predicted gene, 26127 Neighboring gene STARR-positive B cell enhancer ABC_E9512 Neighboring gene predicted gene, 30067 Neighboring gene STARR-seq mESC enhancer starr_04343 Neighboring gene developmental pluripotency associated 4 pseudogene Neighboring gene mitochondrial ribosomal protein L40 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E3372 Neighboring gene protein phosphatase 6, catalytic subunit Neighboring gene STARR-seq mESC enhancer starr_04346 Neighboring gene STARR-seq mESC enhancer starr_04347 Neighboring gene vomeronasal 2, receptor, pseudogene 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The Protexin complex counters resection on stalled forks to promote homologous recombination and crosslink repair. Adeyemi RO, et al. Mol Cell, 2021 Nov 4. PMID 34597596, Free PMC Article
  2. SCAI promotes DNA double-strand break repair in distinct chromosomal contexts. Hansen RK, et al. Nat Cell Biol, 2016 Dec. PMID 27820601, Free PMC Article
  3. Characterization and role of SCAI during renal fibrosis and epithelial-to-mesenchymal transition. Fintha A, et al. Am J Pathol, 2013 Feb. PMID 23178076
  4. SCAI acts as a suppressor of cancer cell invasion through the transcriptional control of beta1-integrin. Brandt DT, et al. Nat Cell Biol, 2009 May. PMID 19350017
  5. Activity-dependent neuroprotective protein recruits HP1 and CHD4 to control lineage-specifying genes. Ostapcuk V, et al. Nature, 2018 May. PMID 29795351

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The Protexin complex counters resection on stalled forks to promote homologous recombination and crosslink repair.
    Title: The Protexin complex counters resection on stalled forks to promote homologous recombination and crosslink repair.
  2. SCAI (suppressor of cancer cell invasion) is identified as a 53BP1-interacting chromatin-associated protein that promotes the functionality of several DNA double-strand breaks repair pathways in mammalian cells.
    Title: SCAI promotes DNA double-strand break repair in distinct chromosomal contexts.
  3. SCAI is a novel transcriptional cofactor that regulates epithelial-to-mesenchymal transition and renal fibrosis.
    Title: Characterization and role of SCAI during renal fibrosis and epithelial-to-mesenchymal transition.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription corepressor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transcription corepressor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of Rho protein signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of cell migration IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of cell migration ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
protein SCAI
Names
suppressor of cancer cell invasion protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001399623.1 → NP_001386552.1  protein SCAI isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL844588, AL845350, AL928639

  2. NM_001399624.1 → NP_001386553.1  protein SCAI isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL844588, AL845350, AL928639

  3. NM_001399625.1 → NP_001386554.1  protein SCAI isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL844588, AL845350, AL928639

  4. NM_178778.4 → NP_848893.2  protein SCAI isoform 1

    See identical proteins and their annotated locations for NP_848893.2

    Status: VALIDATED

    Source sequence(s)
    AL844588, AL845350, AL928639
    Consensus CDS
    CCDS38121.1
    UniProtKB/Swiss-Prot
    A2RTF5, A3KGQ2, Q8C409, Q8C8K2, Q8C8N2
    UniProtKB/TrEMBL
    Q8C4E7
    Related
    ENSMUSP00000037194.6, ENSMUST00000038874.12
    Conserved Domains (1) summary
    pfam12070
    Location:64 → 557
    SCAI; Protein SCAI

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    38956226..39080770 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036162303.1 → XP_036018196.1  protein SCAI isoform X4

    UniProtKB/TrEMBL
    Q3TQB4
    Conserved Domains (1) summary
    pfam12070
    Location:64 → 357
    SCAI; Protein SCAI

  2. XM_036162305.1 → XP_036018198.1  protein SCAI isoform X6

    UniProtKB/TrEMBL
    Q3TQB4
    Conserved Domains (1) summary
    pfam12070
    Location:64 → 357
    SCAI; Protein SCAI

  3. XM_036162302.1 → XP_036018195.1  protein SCAI isoform X3

    UniProtKB/TrEMBL
    A0A0N4SVJ6
    Conserved Domains (1) summary
    pfam12070
    Location:64 → 446
    SCAI; Protein SCAI

  4. XM_036162301.1 → XP_036018194.1  protein SCAI isoform X3

    UniProtKB/TrEMBL
    A0A0N4SVJ6
    Conserved Domains (1) summary
    pfam12070
    Location:64 → 446
    SCAI; Protein SCAI

  5. XM_036162304.1 → XP_036018197.1  protein SCAI isoform X5

    UniProtKB/TrEMBL
    Q3TQB4
    Conserved Domains (1) summary
    pfam12070
    Location:64 → 357
    SCAI; Protein SCAI

  6. XM_036162299.1 → XP_036018192.1  protein SCAI isoform X1

    UniProtKB/TrEMBL
    A0A0N4SVJ6
    Related
    ENSMUSP00000145133.2, ENSMUST00000204093.3
    Conserved Domains (1) summary
    pfam12070
    Location:64 → 468
    SCAI; Protein SCAI

  7. XM_036162300.1 → XP_036018193.1  protein SCAI isoform X2

    Conserved Domains (1) summary
    pfam12070
    Location:64 → 357
    SCAI; Protein SCAI
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8C8N2.2 GenPept UniProtKB/Swiss-Prot:Q8C8N2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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