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Tafa1 TAFA chemokine like family member 1 [ Mus musculus (house mouse) ]

Gene ID: 320265, updated on 21-Apr-2024

Summary

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Official Symbol
Tafa1provided by MGI
Official Full Name
TAFA chemokine like family member 1provided by MGI
Primary source
MGI:MGI:2443695
See related
Ensembl:ENSMUSG00000059187 AllianceGenome:MGI:2443695
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tafa-1; Fam19a1; C630007B19Rik; FAM19A1 TAFA-1
Summary
This gene is a member of the TAFA family which is composed of five highly homologous genes that encode small secreted proteins. These proteins contain conserved cysteine residues at fixed positions, and are distantly related to MIP-1alpha, a member of the CC-chemokine family. The TAFA proteins are predominantly expressed in specific regions of the brain, and are postulated to function as brain-specific chemokines or neurokines that act as regulators of immune and nervous cells. [provided by RefSeq, Jul 2008]
Expression
Biased expression in cortex adult (RPKM 3.1), CNS E18 (RPKM 2.3) and 6 other tissues See more
Orthologs
human all
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Genomic context

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Location:
6 D3; 6 44.67 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (96090135..96634169)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (96113154..96657204)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2900060L22 gene Neighboring gene phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoribosylaminoimidazole, succinocarboxamide synthetase pseudogene Neighboring gene STARR-seq mESC enhancer starr_16753 Neighboring gene STARR-seq mESC enhancer starr_16754 Neighboring gene calmodulin 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_16755 Neighboring gene nucleoporin 50 like Neighboring gene STARR-seq mESC enhancer starr_16758 Neighboring gene STARR-seq mESC enhancer starr_16759 Neighboring gene STARR-seq mESC enhancer starr_16760 Neighboring gene predicted gene, 22971 Neighboring gene STARR-seq mESC enhancer starr_16762 Neighboring gene predicted gene, 26011 Neighboring gene STARR-seq mESC enhancer starr_16763 Neighboring gene STARR-seq mESC enhancer starr_16764 Neighboring gene STARR-seq mESC enhancer starr_16765 Neighboring gene STARR-seq mESC enhancer starr_16766 Neighboring gene TAFA chemokine like family member 4 Neighboring gene STARR-seq mESC enhancer starr_16767 Neighboring gene STARR-seq mESC enhancer starr_16770 Neighboring gene STARR-seq mESC enhancer starr_16771 Neighboring gene STARR-seq mESC enhancer starr_16773 Neighboring gene STARR-seq mESC enhancer starr_16775 Neighboring gene EGF domain specific O-linked N-acetylglucosamine transferase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Alterations in Dendritic Spine Maturation and Neurite Development Mediated by FAM19A1. Yong HJ, et al. Cells, 2021 Jul 23. PMID 34440636, Free PMC Article
  2. FAM19A1, a brain-enriched and metabolically responsive neurokine, regulates food intake patterns and mouse behaviors. Lei X, et al. FASEB J, 2019 Dec. PMID 31689372, Free PMC Article
  3. Deorphanizing FAM19A proteins as pan-neurexin ligands with an unusual biosynthetic binding mechanism. Khalaj AJ, et al. J Cell Biol, 2020 Sep 7. PMID 32706374, Free PMC Article
  4. FAM19A1 is a new ligand for GPR1 that modulates neural stem-cell proliferation and differentiation. Zheng C, et al. FASEB J, 2018 May 25. PMID 29799787
  5. The unique expression profile of FAM19A1 in the mouse brain and its association with hyperactivity, long-term memory and fear acquisition. Yong HJ, et al. Sci Rep, 2020 Mar 2. PMID 32123192, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Alterations in Dendritic Spine Maturation and Neurite Development Mediated by FAM19A1.
    Title: Alterations in Dendritic Spine Maturation and Neurite Development Mediated by FAM19A1.
  2. Deorphanizing FAM19A proteins as pan-neurexin ligands with an unusual biosynthetic binding mechanism.
    Title: Deorphanizing FAM19A proteins as pan-neurexin ligands with an unusual biosynthetic binding mechanism.
  3. In male mice, FAM19A1 deficiency alters food intake patterns during the light and dark cycle. Fam19a1 KO mice are hyperactive, and locomotor hyperactivity is more pronounced in female KO mice.
    Title: FAM19A1, a brain-enriched and metabolically responsive neurokine, regulates food intake patterns and mouse behaviors.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2) 
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables receptor ligand activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables receptor ligand activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in neuroblast differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neuroblast differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of neuroblast proliferation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of neuroblast proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of signaling receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
chemokine-like protein TAFA-1
Names
family with sequence similarity 19, member A1
protein FAM19A1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_182808.3 → NP_877960.1  chemokine-like protein TAFA-1 precursor

    See identical proteins and their annotated locations for NP_877960.1

    Status: VALIDATED

    Source sequence(s)
    AC158674, AK049880, AK050001, AY325120
    Consensus CDS
    CCDS39574.1
    UniProtKB/Swiss-Prot
    A2RSN6, Q7TPG8
    Related
    ENSMUSP00000113152.2, ENSMUST00000122120.8
    Conserved Domains (1) summary
    pfam12020
    Location:41 → 129
    TAFA; TAFA family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    96090135..96634169
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017321638.3 → XP_017177127.1  chemokine-like protein TAFA-1 isoform X1

    Conserved Domains (1) summary
    pfam12020
    Location:65 → 153
    TAFA; TAFA family

  2. XM_036166225.1 → XP_036022118.1  chemokine-like protein TAFA-1 isoform X2

    Conserved Domains (1) summary
    pfam12020
    Location:40 → 128
    TAFA; TAFA family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7TPG8.1 GenPept UniProtKB/Swiss-Prot:Q7TPG8

Gene LinkOut

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