Dlec1 deleted in lung and esophageal cancer 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dlec1provided by MGI
Official Full Name: deleted in lung and esophageal cancer 1provided by MGI
Primary source: MGI:MGI:2443671
See related: Ensembl:ENSMUSG00000038060 AllianceGenome:MGI:2443671
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: D630005C06Rik
Summary: Predicted to enable alpha-tubulin binding activity and beta-tubulin binding activity. Involved in spermatogenesis. Predicted to be located in cytosol. Is expressed in brain and testis. Human ortholog(s) of this gene implicated in acute myeloid leukemia. Orthologous to human DLEC1 (DLEC1 cilia and flagella associated protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in kidney adult (RPKM 9.1), testis adult (RPKM 9.0) and 9 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 F3; 9 71.32 cM

Exon count:: 39

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (118927720..118977314)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (119102444..119148246)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Dlec1 is required for spermatogenesis and male fertility in mice.
Title: Dlec1 is required for spermatogenesis and male fertility in mice.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)
Endonuclease-mediated (1) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables alpha-tubulin binding	ISO Inferred from Sequence Orthology more info
enables beta-tubulin binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in defense response to tumor cell	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: deleted in lung and esophageal cancer protein 1 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001368820.1 → NP_001355749.1 deleted in lung and esophageal cancer protein 1 homolog isoform 2

Status: VALIDATED

Source sequence(s)

AC055818
NM_001368821.1 → NP_001355750.1 deleted in lung and esophageal cancer protein 1 homolog isoform 3

Status: VALIDATED

Source sequence(s)

AC055818
NM_177117.5 → NP_796091.2 deleted in lung and esophageal cancer protein 1 homolog isoform 1

Status: VALIDATED

Source sequence(s)

AC055818

Consensus CDS

CCDS52963.1

UniProtKB/TrEMBL

E9Q8C0

Related

ENSMUSP00000128874.2, ENSMUST00000165231.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

118927720..118977314

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006512152.5 → XP_006512215.1 deleted in lung and esophageal cancer protein 1 homolog isoform X1
XM_006512155.5 → XP_006512218.1 deleted in lung and esophageal cancer protein 1 homolog isoform X4
XM_006512154.5 → XP_006512217.1 deleted in lung and esophageal cancer protein 1 homolog isoform X3

UniProtKB/TrEMBL

D3Z6E8

Related

ENSMUSP00000122380.2, ENSMUST00000140326.8
XM_006512156.5 → XP_006512219.1 deleted in lung and esophageal cancer protein 1 homolog isoform X5
XM_006512153.5 → XP_006512216.1 deleted in lung and esophageal cancer protein 1 homolog isoform X2
XM_036155059.1 → XP_036010952.1 deleted in lung and esophageal cancer protein 1 homolog isoform X6

Conserved Domains (1) summary

cl13764
Location:605 → 710

ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin
XM_036155060.1 → XP_036010953.1 deleted in lung and esophageal cancer protein 1 homolog isoform X6

Conserved Domains (1) summary

cl13764
Location:605 → 710

ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin
XM_006512158.5 → XP_006512221.1 deleted in lung and esophageal cancer protein 1 homolog isoform X7
XM_006512159.1 → XP_006512222.1 deleted in lung and esophageal cancer protein 1 homolog isoform X8