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Marchf3 membrane associated ring-CH-type finger 3 [ Mus musculus (house mouse) ]

Gene ID: 320253, updated on 5-Mar-2024

Summary

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Official Symbol
Marchf3provided by MGI
Official Full Name
membrane associated ring-CH-type finger 3provided by MGI
Primary source
MGI:MGI:2443667
See related
Ensembl:ENSMUSG00000032656 AllianceGenome:MGI:2443667
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
March3; MARCH-III; 6330411I15Rik; A530081L18Rik
Summary
Predicted to enable ubiquitin-protein transferase activity. Predicted to be involved in protein ubiquitination. Predicted to act upstream of or within endocytosis. Predicted to be located in endosome and lysosome. Is expressed in several structures, including alimentary system; brain; eye; genitourinary system; and integumental system. Orthologous to human MARCHF3 (membrane associated ring-CH-type finger 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver E14.5 (RPKM 13.9), liver E14 (RPKM 12.2) and 21 other tissues See more
Orthologs
human all
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Genomic context

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Location:
18 D3; 18 30.92 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (56894788..57058587, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (56761716..56925515, complement)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10992 Neighboring gene predicted gene, 41738 Neighboring gene lamin B1 Neighboring gene STARR-seq mESC enhancer starr_44677 Neighboring gene predicted gene 15345 Neighboring gene VISTA enhancer mm109 Neighboring gene STARR-positive B cell enhancer ABC_E5663 Neighboring gene STARR-positive B cell enhancer ABC_E1959 Neighboring gene ribosomal protein S3 pseudogene Neighboring gene STARR-seq mESC enhancer starr_44682 Neighboring gene predicted gene, 34632 Neighboring gene RIKEN cDNA C330018D20 gene Neighboring gene predicted gene 10536

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. MARCH3 attenuates IL-1β-triggered inflammation by mediating K48-linked polyubiquitination and degradation of IL-1RI. Lin H, et al. Proc Natl Acad Sci U S A, 2018 Dec 4. PMID 30442668, Free PMC Article
  2. The membrane-associated ubiquitin ligases MARCH2 and MARCH3 target IL-5 receptor alpha to negatively regulate eosinophilic airway inflammation. Zeng LW, et al. Cell Mol Immunol, 2022 Oct. PMID 35982175, Free PMC Article
  3. MARCH3 negatively regulates IL-3-triggered inflammatory response by mediating K48-linked polyubiquitination and degradation of IL-3Rα. Feng L, et al. Signal Transduct Target Ther, 2022 Jan 24. PMID 35075102, Free PMC Article
  4. Integrated microarray and ChIP analysis identifies multiple Foxa2 dependent target genes in the notochord. Tamplin OJ, et al. Dev Biol, 2011 Dec 15. PMID 22008794
  5. A global genomic transcriptional code associated with CNS-expressed genes. Bailey PJ, et al. Exp Cell Res, 2006 Oct 1. PMID 16919269

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The membrane-associated ubiquitin ligases MARCH2 and MARCH3 target IL-5 receptor alpha to negatively regulate eosinophilic airway inflammation.
    Title: The membrane-associated ubiquitin ligases MARCH2 and MARCH3 target IL-5 receptor alpha to negatively regulate eosinophilic airway inflammation.
  2. MARCH3 negatively regulates IL-3-triggered inflammatory response by mediating K48-linked polyubiquitination and degradation of IL-3Ralpha.
    Title: MARCH3 negatively regulates IL-3-triggered inflammatory response by mediating K48-linked polyubiquitination and degradation of IL-3Rα.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (1)  1 citation

General gene information

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Markers

Homology

Clone Names

  • MGC130167, MGC130168

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin-protein transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within endocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in endosome ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in lysosome ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase MARCHF3
Names
E3 ubiquitin-protein ligase MARCH3
RING-type E3 ubiquitin transferase MARCH3
RING-type E3 ubiquitin transferase MARCHF3
membrane-associated RING finger protein 3
membrane-associated RING-CH protein III
membrane-associated ring finger (C3HC4) 3
NP_001361156.1
NP_001361157.1
NP_796089.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001374227.1 → NP_001361156.1  E3 ubiquitin-protein ligase MARCHF3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC109152, AC158763
    Consensus CDS
    CCDS89244.1
    UniProtKB/TrEMBL
    F8WJC4
    Related
    ENSMUSP00000047946.7, ENSMUST00000035278.7
    Conserved Domains (1) summary
    cd16699
    Location:70 → 120
    RING_CH-C4HC3_MARCH2_like; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING finger protein MARCH2, MARCH3, and similar proteins

  2. NM_001374228.1 → NP_001361157.1  E3 ubiquitin-protein ligase MARCHF3 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC109152, AC158763
    Conserved Domains (1) summary
    cd16699
    Location:70 → 120
    RING_CH-C4HC3_MARCH2_like; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING finger protein MARCH2, MARCH3, and similar proteins

  3. NM_177115.3 → NP_796089.1  E3 ubiquitin-protein ligase MARCHF3 isoform 2

    See identical proteins and their annotated locations for NP_796089.1

    Status: VALIDATED

    Source sequence(s)
    AC109152, AC158763
    Consensus CDS
    CCDS29262.1
    UniProtKB/Swiss-Prot
    Q3KNK5, Q8BRX9
    Related
    ENSMUSP00000099976.2, ENSMUST00000102912.8
    Conserved Domains (1) summary
    cd16699
    Location:70 → 120
    RING_CH-C4HC3_MARCH2_like; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING finger protein MARCH2, MARCH3, and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    56894788..57058587 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BRX9.1 GenPept UniProtKB/Swiss-Prot:Q8BRX9

Gene LinkOut

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