Etfbkmt electron transfer flavoprotein beta subunit lysine methyltransferase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Etfbkmtprovided by MGI
Official Full Name: electron transfer flavoprotein beta subunit lysine methyltransferaseprovided by MGI
Primary source: MGI:MGI:2443575
See related: Ensembl:ENSMUSG00000039958 AllianceGenome:MGI:2443575
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mettl20; ETFB-KMT; 4833442J19Rik
Summary: Enables protein-lysine N-methyltransferase activity. Involved in negative regulation of fatty acid beta-oxidation using acyl-CoA dehydrogenase and peptidyl-lysine trimethylation. Predicted to be located in cytoplasm. Predicted to be part of protein-containing complex. Predicted to be active in mitochondrial matrix. Is expressed in several structures, including central nervous system; gut; male reproductive gland or organ; respiratory system; and thymus. Orthologous to human ETFBKMT (electron transfer flavoprotein subunit beta lysine methyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in bladder adult (RPKM 13.6), heart adult (RPKM 5.1) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 G3; 6 78.8 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (149042980..149052669)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (149141476..149151171)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results further indicate that METTL20-mediated protein methylation is not essential in humans but more likely modulates energy production during fasting or under other metabolic conditions where beta-oxidation is up-regulated.
Title: Role of METTL20 in regulating β-oxidation and heat production in mice under fasting or ketogenic conditions.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1) 1 citation
Targeted (2)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables heat shock protein binding	ISO Inferred from Sequence Orthology more info
enables methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables protein-lysine N-methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein-lysine N-methyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein-lysine N-methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within methylation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of fatty acid beta-oxidation using acyl-CoA dehydrogenase	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of fatty acid beta-oxidation using acyl-CoA dehydrogenase	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-lysine trimethylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in peptidyl-lysine trimethylation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrial matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial matrix	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: electron transfer flavoprotein beta subunit lysine methyltransferase

Names: ETFB lysine methyltransferase; methyltransferase like 20; methyltransferase-like protein 20; protein N-lysine methyltransferase METTL20

NP_001239023.1

EC 2.1.1.-

NP_001239024.1

EC 2.1.1.-

NP_001239025.1

EC 2.1.1.-

NP_001239026.1

EC 2.1.1.-

NP_796075.2

EC 2.1.1.-

XP_017177126.1

EC 2.1.1.-

XP_030111316.1

EC 2.1.1.-

XP_036022115.1

EC 2.1.1.-

XP_036022116.1

EC 2.1.1.-

XP_036022117.1

EC 2.1.1.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001252094.1 → NP_001239023.1 electron transfer flavoprotein beta subunit lysine methyltransferase isoform a

See identical proteins and their annotated locations for NP_001239023.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1-4 all encode isoform a.

Source sequence(s)

AK132096, BB614316, BC048711, BY081844

Consensus CDS

CCDS20715.1

UniProtKB/Swiss-Prot

B8JKU7, Q3V219, Q80ZM3, Q8VEL3

Related

ENSMUSP00000107176.2, ENSMUST00000111551.2

Conserved Domains (1) summary

cl17173
Location:58 → 253

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
NM_001252095.1 → NP_001239024.1 electron transfer flavoprotein beta subunit lysine methyltransferase isoform a

See identical proteins and their annotated locations for NP_001239024.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1, and encodes the longer isoform (a). Variants 1-4 all encode isoform a.

Source sequence(s)

BC048711, BY081844, BY135669

Consensus CDS

CCDS20715.1

UniProtKB/Swiss-Prot

B8JKU7, Q3V219, Q80ZM3, Q8VEL3

Conserved Domains (1) summary

cl17173
Location:58 → 253

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
NM_001252096.1 → NP_001239025.1 electron transfer flavoprotein beta subunit lysine methyltransferase isoform a

See identical proteins and their annotated locations for NP_001239025.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1, and encodes the longer isoform (a). Variants 1-4 all encode isoform a.

Source sequence(s)

BB614316, BC048711, BY081844, DN174886

Consensus CDS

CCDS20715.1

UniProtKB/Swiss-Prot

B8JKU7, Q3V219, Q80ZM3, Q8VEL3

Related

ENSMUSP00000136167.2, ENSMUST00000179873.8

Conserved Domains (1) summary

cl17173
Location:58 → 253

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
NM_001252097.1 → NP_001239026.1 electron transfer flavoprotein beta subunit lysine methyltransferase isoform b

See identical proteins and their annotated locations for NP_001239026.1

Status: VALIDATED

Description

Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a.

Source sequence(s)

BC046911, BY081844

Consensus CDS

CCDS85191.1

UniProtKB/TrEMBL

Q80VP4

Related

ENSMUSP00000144830.2, ENSMUST00000147934.4

Conserved Domains (1) summary

cl17173
Location:3 → 126

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
NM_177101.5 → NP_796075.2 electron transfer flavoprotein beta subunit lysine methyltransferase isoform a

See identical proteins and their annotated locations for NP_796075.2

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1, and encodes the longer isoform (a). Variants 1-4 all encode isoform a.

Source sequence(s)

BC048711, BY081844

Consensus CDS

CCDS20715.1

UniProtKB/Swiss-Prot

B8JKU7, Q3V219, Q80ZM3, Q8VEL3

Related

ENSMUSP00000042102.10, ENSMUST00000047531.16

Conserved Domains (1) summary

cl17173
Location:58 → 253

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

149042980..149052669

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036166224.1 → XP_036022117.1 electron transfer flavoprotein beta subunit lysine methyltransferase isoform X3

UniProtKB/TrEMBL

Q80VP4

Conserved Domains (1) summary

cl17173
Location:3 → 126

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
XM_030255456.2 → XP_030111316.1 electron transfer flavoprotein beta subunit lysine methyltransferase isoform X3

UniProtKB/TrEMBL

Q80VP4

Conserved Domains (1) summary

cl17173
Location:3 → 126

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
XM_036166223.1 → XP_036022116.1 electron transfer flavoprotein beta subunit lysine methyltransferase isoform X2

UniProtKB/TrEMBL

E9PY99

Related

ENSMUSP00000118701.2, ENSMUST00000134306.8

Conserved Domains (1) summary

cl17173
Location:58 → 158

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
XM_036166222.1 → XP_036022115.1 electron transfer flavoprotein beta subunit lysine methyltransferase isoform X1

UniProtKB/Swiss-Prot

B8JKU7, Q3V219, Q80ZM3, Q8VEL3

Conserved Domains (1) summary

cl17173
Location:58 → 253

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
XM_017321637.3 → XP_017177126.1 electron transfer flavoprotein beta subunit lysine methyltransferase isoform X1

UniProtKB/Swiss-Prot

B8JKU7, Q3V219, Q80ZM3, Q8VEL3

Conserved Domains (1) summary

cl17173
Location:58 → 253

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...