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Hook3 hook microtubule tethering protein 3 [ Mus musculus (house mouse) ]

Gene ID: 320191, updated on 11-Apr-2024

Summary

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Official Symbol
Hook3provided by MGI
Official Full Name
hook microtubule tethering protein 3provided by MGI
Primary source
MGI:MGI:2443554
See related
Ensembl:ENSMUSG00000037234 AllianceGenome:MGI:2443554
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
5830454D03Rik; E330005F07Rik
Summary
Predicted to enable several functions, including cytoskeletal protein binding activity; dynein intermediate chain binding activity; and dynein light chain binding activity. Involved in negative regulation of neurogenesis. Acts upstream of or within several processes, including interkinetic nuclear migration; microtubule anchoring at centrosome; and neuronal stem cell population maintenance. Located in centriolar satellite; cytoplasm; and pericentriolar material. Is expressed in brain; future brain; and genitourinary system. Orthologous to human HOOK3 (hook microtubule tethering protein 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E14 (RPKM 5.4), whole brain E14.5 (RPKM 5.0) and 25 other tissues See more
Orthologs
human all
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Genomic context

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Location:
8 A2; 8 14.29 cM
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (26511449..26609646, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (26021421..26119618, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31402 Neighboring gene protein-O-mannose kinase Neighboring gene STARR-seq mESC enhancer starr_20994 Neighboring gene farnesyltransferase, CAAX box, alpha Neighboring gene STARR-seq mESC enhancer starr_20995 Neighboring gene STARR-seq mESC enhancer starr_20996 Neighboring gene RIKEN cDNA 1700047A11 gene Neighboring gene STARR-seq mESC enhancer starr_20998 Neighboring gene calcium binding protein 39 pseudogene Neighboring gene ring finger protein 170 Neighboring gene STARR-positive B cell enhancer ABC_E879 Neighboring gene STARR-seq mESC enhancer starr_20999 Neighboring gene THAP domain containing, apoptosis associated protein 1 Neighboring gene STARR-seq mESC enhancer starr_21000 Neighboring gene STARR-seq mESC enhancer starr_21002 Neighboring gene STARR-seq mESC enhancer starr_21003 Neighboring gene predicted gene, 31727

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The Salmonella SpiC protein targets the mammalian Hook3 protein function to alter cellular trafficking. Shotland Y, et al. Mol Microbiol, 2003 Sep. PMID 12950921
  2. IIGP, a member of the IFN inducible and microbial defense mediating 47 kDa GTPase family, interacts with the microtubule binding protein hook3. Kaiser F, et al. J Cell Sci, 2004 Apr 1. PMID 15075236
  3. Hook Adaptors Induce Unidirectional Processive Motility by Enhancing the Dynein-Dynactin Interaction. Olenick MA, et al. J Biol Chem, 2016 Aug 26. PMID 27365401, Free PMC Article
  4. The microtubule-binding protein Hook3 interacts with a cytoplasmic domain of scavenger receptor A. Sano H, et al. J Biol Chem, 2007 Mar 16. PMID 17237231
  5. Hook3 interacts with PCM1 to regulate pericentriolar material assembly and the timing of neurogenesis. Ge X, et al. Neuron, 2010 Jan 28. PMID 20152126, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Single-molecule motility assays using total internal reflection fluorescence microscopy indicate that both Hook1 and Hook3 effectively activate cytoplasmic dynein, inducing longer run lengths and higher velocities than the previously characterized dynein activator bicaudal D2 (BICD2).
    Title: Hook Adaptors Induce Unidirectional Processive Motility by Enhancing the Dynein-Dynactin Interaction.
  2. Identified hook3 as the first cooperation partner of a member of the 47 kDa GTPase protein family (IIGP) and indicated that hook3 links in an IFNgamma-inducible fashion to cytoskeleton-based membrane trafficking.
    Title: IIGP, a member of the IFN inducible and microbial defense mediating 47 kDa GTPase family, interacts with the microtubule binding protein hook3.
  3. Hook3 interacts with a cytoplasmic domain of scavenger receptor A
    Title: The microtubule-binding protein Hook3 interacts with a cytoplasmic domain of scavenger receptor A.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3) 
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables dynactin binding ISO
Inferred from Sequence Orthology
more info
  
enables dynein intermediate chain binding ISO
Inferred from Sequence Orthology
more info
  
enables dynein light chain binding ISO
Inferred from Sequence Orthology
more info
  
enables dynein light intermediate chain binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in Golgi localization ISO
Inferred from Sequence Orthology
more info
  
involved_in cytoplasmic microtubule organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cytoplasmic microtubule organization ISO
Inferred from Sequence Orthology
more info
  
involved_in cytoskeleton-dependent intracellular transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in early endosome to late endosome transport ISO
Inferred from Sequence Orthology
more info
  
involved_in endosome organization ISO
Inferred from Sequence Orthology
more info
  
involved_in endosome to lysosome transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within interkinetic nuclear migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lysosome organization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within microtubule anchoring at centrosome IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of neurogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within neuronal stem cell population maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within protein localization to centrosome IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of FHF complex ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
part_of HOPS complex ISO
Inferred from Sequence Orthology
more info
  
located_in centriolar satellite IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centrosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cis-Golgi network ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
located_in pericentriolar material IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
protein Hook homolog 3
Names
hook homolog 3
mHK3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_207659.3 → NP_997542.1  protein Hook homolog 3

    See identical proteins and their annotated locations for NP_997542.1

    Status: VALIDATED

    Source sequence(s)
    AC093366
    Consensus CDS
    CCDS22206.1
    UniProtKB/Swiss-Prot
    Q540A0, Q8BUK6, Q8BV48, Q8BW57, Q8BY41
    UniProtKB/TrEMBL
    Q5BKS5
    Related
    ENSMUSP00000046788.8, ENSMUST00000037182.14
    Conserved Domains (1) summary
    pfam05622
    Location:12 → 710
    HOOK; HOOK protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    26511449..26609646 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006509150.3 → XP_006509213.1  protein Hook homolog 3 isoform X3

    UniProtKB/TrEMBL
    Q5BKS5
    Conserved Domains (1) summary
    pfam05622
    Location:12 → 669
    HOOK; HOOK protein

  2. XM_006509148.3 → XP_006509211.1  protein Hook homolog 3 isoform X1

    UniProtKB/TrEMBL
    Q5BKS5
    Conserved Domains (1) summary
    pfam05622
    Location:12 → 712
    HOOK; HOOK protein

  3. XM_006509149.5 → XP_006509212.1  protein Hook homolog 3 isoform X2

    UniProtKB/TrEMBL
    Q5BKS5
    Conserved Domains (1) summary
    pfam05622
    Location:12 → 676
    HOOK; HOOK protein

RNA

  1. XR_004934842.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BUK6.2 GenPept UniProtKB/Swiss-Prot:Q8BUK6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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