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Tacc1 transforming, acidic coiled-coil containing protein 1 [ Mus musculus (house mouse) ]

Gene ID: 320165, updated on 11-Apr-2024

Summary

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Official Symbol
Tacc1provided by MGI
Official Full Name
transforming, acidic coiled-coil containing protein 1provided by MGI
Primary source
MGI:MGI:2443510
See related
Ensembl:ENSMUSG00000065954 AllianceGenome:MGI:2443510
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4833447E04Rik; B230378H13Rik
Summary
Enables nuclear receptor binding activity; peroxisome proliferator activated receptor binding activity; and protein domain specific binding activity. Acts upstream of or within microtubule cytoskeleton organization; nervous system development; and regulation of microtubule-based process. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; branchial arch; cardiovascular system; central nervous system; and respiratory system. Orthologous to human TACC1 (transforming acidic coiled-coil containing protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 20.7), bladder adult (RPKM 18.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Tacc1 in Genome Data Viewer
Location:
8 A2; 8 13.7 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (25644568..25730901, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (25154552..25256424, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene pleckstrin homology domain-containing, family A (phosphoinositide binding specific) member 2 Neighboring gene RIKEN cDNA 5830408C22 gene Neighboring gene STARR-positive B cell enhancer mm9_chr8:26213490-26213791 Neighboring gene STARR-seq mESC enhancer starr_20960 Neighboring gene STARR-positive B cell enhancer ABC_E8231 Neighboring gene STARR-positive B cell enhancer ABC_E11742 Neighboring gene STARR-positive B cell enhancer ABC_E6629 Neighboring gene STARR-seq mESC enhancer starr_20962 Neighboring gene STARR-seq mESC enhancer starr_20963 Neighboring gene predicted gene, 39143 Neighboring gene microRNA 8108 Neighboring gene STARR-seq mESC enhancer starr_20967 Neighboring gene STARR-seq mESC enhancer starr_20968 Neighboring gene predicted gene, 39144 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:26384741-26384933 Neighboring gene predicted gene, 39145

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Disruption of de novo fatty acid synthesis via acetyl-CoA carboxylase 1 inhibition prevents acute graft-versus-host disease. Raha S, et al. Eur J Immunol, 2016 Sep. PMID 27338930
  2. Temporal and spatial expression of TACC1 in the mouse and human. Lauffart B, et al. Dev Dyn, 2006 Jun. PMID 16496324
  3. The centrosomal, putative tumor suppressor protein TACC2 is dispensable for normal development, and deficiency does not lead to cancer. Schuendeln MM, et al. Mol Cell Biol, 2004 Jul. PMID 15226440, Free PMC Article
  4. The transforming acidic coiled coil (TACC1) protein modulates the transcriptional activity of the nuclear receptors TR and RAR. Guyot R, et al. BMC Mol Biol, 2010 Jan 15. PMID 20078863, Free PMC Article
  5. Molecular contribution to cleft palate production in cleft lip mice. Sasaki Y, et al. Congenit Anom (Kyoto), 2014 May. PMID 24206222, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • 4833447E04Rik, B230378H13Rik

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables nuclear estrogen receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables nuclear glucocorticoid receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables nuclear receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables nuclear receptor coactivator activity ISO
Inferred from Sequence Orthology
more info
  
enables nuclear retinoic acid receptor binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables nuclear retinoic acid receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables nuclear retinoid X receptor binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables nuclear retinoid X receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables nuclear thyroid hormone receptor binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables nuclear thyroid hormone receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables peroxisome proliferator activated receptor binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables peroxisome proliferator activated receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables protein domain specific binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cell population proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cerebral cortex development IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cerebral cortex development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within interkinetic nuclear migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within microtubule cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic spindle organization IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within neurogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of microtubule-based process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
transforming acidic coiled-coil-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001402841.1 → NP_001389770.1  transforming acidic coiled-coil-containing protein 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC114589

  2. NM_001402842.1 → NP_001389771.1  transforming acidic coiled-coil-containing protein 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC114589

  3. NM_001402843.1 → NP_001389772.1  transforming acidic coiled-coil-containing protein 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC114589

  4. NM_177089.6 → NP_796063.3  transforming acidic coiled-coil-containing protein 1 long isoform

    See identical proteins and their annotated locations for NP_796063.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the long isoform.
    Source sequence(s)
    AC114589
    Consensus CDS
    CCDS40303.1
    UniProtKB/Swiss-Prot
    Q05A66, Q6Y685, Q6Y686
    UniProtKB/TrEMBL
    F8VQ95
    Related
    ENSMUSP00000081043.5, ENSMUST00000084030.6
    Conserved Domains (3) summary
    pfam05010
    Location:570 → 769
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
    pfam09403
    Location:675 → 768
    FadA; Adhesion protein FadA
    cl21478
    Location:577 → 662
    ATP-synt_B; ATP synthase B/B' CF(0)

  5. NM_199323.4 → NP_955355.1  transforming acidic coiled-coil-containing protein 1 short isoform

    See identical proteins and their annotated locations for NP_955355.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. This encodes the short isoform, compared to the long isoform.
    Source sequence(s)
    AC114589
    Consensus CDS
    CCDS40302.1
    UniProtKB/Swiss-Prot
    Q6Y685
    Related
    ENSMUSP00000081560.5, ENSMUST00000084512.11
    Conserved Domains (1) summary
    pfam05010
    Location:162 → 361
    TACC; Transforming acidic coiled-coil-containing protein (TACC)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    25644568..25730901 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6Y685.1 GenPept UniProtKB/Swiss-Prot:Q6Y685

Gene LinkOut

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