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Sp8 trans-acting transcription factor 8 [ Mus musculus (house mouse) ]

Gene ID: 320145, updated on 21-Apr-2024

Summary

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Official Symbol
Sp8provided by MGI
Official Full Name
trans-acting transcription factor 8provided by MGI
Primary source
MGI:MGI:2443471
See related
Ensembl:ENSMUSG00000048562 AllianceGenome:MGI:2443471
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mBtd; D930049B17Rik
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within dorsal/ventral pattern formation; embryonic limb morphogenesis; and proximal/distal pattern formation. Predicted to be located in nucleus. Is expressed in several structures, including 1st branchial arch; brain; embryo ectoderm; sensory organ; and tail bud. Orthologous to human SP8 (Sp8 transcription factor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in frontal lobe adult (RPKM 5.4), whole brain E14.5 (RPKM 1.9) and 4 other tissues See more
Orthologs
human all
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Genomic context

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Location:
12 F2; 12 63.48 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (118809968..118816313)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (118846288..118852578)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_33443 Neighboring gene predicted gene, 29689 Neighboring gene predicted gene 6171 Neighboring gene ATP-binding cassette, sub-family B member 5 Neighboring gene STARR-seq mESC enhancer starr_33448 Neighboring gene STARR-positive B cell enhancer mm9_chr12:120165112-120165412 Neighboring gene STARR-seq mESC enhancer starr_33449 Neighboring gene STARR-seq mESC enhancer starr_33450 Neighboring gene STARR-seq mESC enhancer starr_33451 Neighboring gene STARR-seq mESC enhancer starr_33453 Neighboring gene acyl-Coenzyme A binding domain containing 5 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Transient Sp8+ handlebar-like interneuron structure traversing the corpus callosum during the second postnatal week. Cai Y, et al. Neuroreport, 2015 Mar 4. PMID 25646584
  2. The transcription factor Sp8 is required for the production of parvalbumin-expressing interneurons in the olfactory bulb. Li X, et al. J Neurosci, 2011 Jun 8. PMID 21653849, Free PMC Article
  3. A dual role for the transcription factor Sp8 in postnatal neurogenesis. Gaborieau E, et al. Sci Rep, 2018 Sep 28. PMID 30266956, Free PMC Article
  4. Further characterization of the juxtaglomerular neurons in the mouse main olfactory bulb by transcription factors, Sp8 and Tbx21. Kosaka T, et al. Neurosci Res, 2012 May. PMID 22387948
  5. Emx1-expressing neural stem cells in the subventricular zone give rise to new interneurons in the ischemic injured striatum. Wei B, et al. Eur J Neurosci, 2011 Mar. PMID 21219481

See all (115) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Transcription factors Sp8 and Sp9 regulate the development of caudal ganglionic eminence-derived cortical interneurons.
    Title: Transcription factors Sp8 and Sp9 regulate the development of caudal ganglionic eminence-derived cortical interneurons.
  2. While Sp8 plays an early role in controlling proliferation in all lineages, it is not involved in the early specification of calretinin+ periglomerular interneurons, but plays a crucial role in their long term survival.
    Title: A dual role for the transcription factor Sp8 in postnatal neurogenesis.
  3. our results demonstrate that Sp8 and Sp9 have crucial roles in regulating olfactory bulb interneuron development
    Title: Transcription Factors Sp8 and Sp9 Coordinately Regulate Olfactory Bulb Interneuron Development.
  4. SP8 and SP9 coordinately promote D2-type medium spiny neuron production by activating Six3 expression.
    Title: SP8 and SP9 coordinately promote D2-type medium spiny neuron production by activating Six3 expression.
  5. Sp5/8 bind directly to GC boxes in Wnt target gene enhancers and to adjacent, or distally positioned, chromatin-bound T-cell factor (Tcf) 1/lymphoid enhancer factor (Lef) 1 to facilitate recruitment of beta-catenin to target gene enhancers.
    Title: Sp5 and Sp8 recruit β-catenin and Tcf1-Lef1 to select enhancers to activate Wnt target gene transcription.
  6. Provide the first direct evidence that a transient Sp8+ interneuron handlebar-like structure exists in the CC during a brief postnatal critical period.
    Title: Transient Sp8+ handlebar-like interneuron structure traversing the corpus callosum during the second postnatal week.
  7. Sp5 and Sp8 are pivotal downstream effectors of Wnt3a/beta-catenin that are essential for the self-renewal and differentiation of neuromesodermal stem cells.
    Title: Transcriptional profiling of Wnt3a mutants identifies Sp transcription factors as essential effectors of the Wnt/β-catenin pathway in neuromesodermal stem cells.
  8. Our data are compatible with Sp6 and Sp8 working together and in a dose-dependent manner as indispensable mediators of Wnt/betacatenin and Bmp signaling in the limb ectoderm
    Title: Sp6 and Sp8 transcription factors control AER formation and dorsal-ventral patterning in limb development.
  9. Findings provide evidence that Sp8 and another transcription factor, COUP-TF1, mutually repress each other's cortical neuroepithelial expression along the anterior-posterior and dorsoventral axes
    Title: Sp8 and COUP-TF1 reciprocally regulate patterning and Fgf signaling in cortical progenitors.
  10. The zinc-finger protein Sp8 plays a supplementary role to Pax6 in establishing the pMN/p3 domain boundary.
    Title: Sp8 plays a supplementary role to Pax6 in establishing the pMN/p3 domain boundary in the spinal cord.
Submit: New GeneRIF Correction See all GeneRIFs (19)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (5)  1 citation
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Clone Names

  • MGC105193

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within dorsal/ventral pattern formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within embryonic limb morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in embryonic limb morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within proximal/distal pattern formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
transcription factor Sp8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001379379.1 → NP_001366308.1  transcription factor Sp8 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC131717, CN527217
    UniProtKB/TrEMBL
    Q640M8
    Conserved Domains (4) summary
    sd00017
    Location:379 → 398
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:434 → 456
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:420 → 443
    zf-H2C2_2; Zinc-finger double domain
    cl41771
    Location:19 → 375
    SP6-9_N; N-terminal domains of transcription factor Specificity Proteins (SP) 6-9, and similar proteins

  2. NM_001379380.1 → NP_001366309.1  transcription factor Sp8 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC131717, AK030745
    UniProtKB/Swiss-Prot
    Q8BMJ8, Q8BWA3
    UniProtKB/TrEMBL
    Q5QR90, Q640M8
    Conserved Domains (4) summary
    sd00017
    Location:361 → 380
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:416 → 438
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:402 → 425
    zf-H2C2_2; Zinc-finger double domain
    cl41771
    Location:1 → 357
    SP6-9_N; N-terminal domains of transcription factor Specificity Proteins (SP) 6-9, and similar proteins

  3. NM_177082.4 → NP_796056.2  transcription factor Sp8 isoform 2

    See identical proteins and their annotated locations for NP_796056.2

    Status: VALIDATED

    Source sequence(s)
    AC131717, AK053093
    Consensus CDS
    CCDS26213.1
    UniProtKB/Swiss-Prot
    Q8BMJ8, Q8BWA3
    UniProtKB/TrEMBL
    Q5QR90, Q640M8
    Related
    ENSMUSP00000065746.3, ENSMUST00000063918.4
    Conserved Domains (4) summary
    sd00017
    Location:361 → 380
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:416 → 438
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:402 → 425
    zf-H2C2_2; Zinc-finger double domain
    cl41771
    Location:1 → 357
    SP6-9_N; N-terminal domains of transcription factor Specificity Proteins (SP) 6-9, and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    118809968..118816313
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006515987.5 → XP_006516050.1  transcription factor Sp8 isoform X1

    See identical proteins and their annotated locations for XP_006516050.1

    UniProtKB/Swiss-Prot
    Q8BMJ8, Q8BWA3
    UniProtKB/TrEMBL
    Q5QR90, Q640M8
    Conserved Domains (4) summary
    sd00017
    Location:361 → 380
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:416 → 438
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:402 → 425
    zf-H2C2_2; Zinc-finger double domain
    cl41771
    Location:1 → 357
    SP6-9_N; N-terminal domains of transcription factor Specificity Proteins (SP) 6-9, and similar proteins

  2. XM_006515986.5 → XP_006516049.1  transcription factor Sp8 isoform X1

    See identical proteins and their annotated locations for XP_006516049.1

    UniProtKB/Swiss-Prot
    Q8BMJ8, Q8BWA3
    UniProtKB/TrEMBL
    Q5QR90, Q640M8
    Conserved Domains (4) summary
    sd00017
    Location:361 → 380
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:416 → 438
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:402 → 425
    zf-H2C2_2; Zinc-finger double domain
    cl41771
    Location:1 → 357
    SP6-9_N; N-terminal domains of transcription factor Specificity Proteins (SP) 6-9, and similar proteins

  3. XM_006515985.5 → XP_006516048.1  transcription factor Sp8 isoform X1

    See identical proteins and their annotated locations for XP_006516048.1

    UniProtKB/Swiss-Prot
    Q8BMJ8, Q8BWA3
    UniProtKB/TrEMBL
    Q5QR90, Q640M8
    Conserved Domains (4) summary
    sd00017
    Location:361 → 380
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:416 → 438
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:402 → 425
    zf-H2C2_2; Zinc-finger double domain
    cl41771
    Location:1 → 357
    SP6-9_N; N-terminal domains of transcription factor Specificity Proteins (SP) 6-9, and similar proteins

  4. XM_006515983.5 → XP_006516046.1  transcription factor Sp8 isoform X1

    See identical proteins and their annotated locations for XP_006516046.1

    UniProtKB/Swiss-Prot
    Q8BMJ8, Q8BWA3
    UniProtKB/TrEMBL
    Q5QR90, Q640M8
    Conserved Domains (4) summary
    sd00017
    Location:361 → 380
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:416 → 438
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:402 → 425
    zf-H2C2_2; Zinc-finger double domain
    cl41771
    Location:1 → 357
    SP6-9_N; N-terminal domains of transcription factor Specificity Proteins (SP) 6-9, and similar proteins

  5. XM_006515988.5 → XP_006516051.1  transcription factor Sp8 isoform X1

    See identical proteins and their annotated locations for XP_006516051.1

    UniProtKB/Swiss-Prot
    Q8BMJ8, Q8BWA3
    UniProtKB/TrEMBL
    Q5QR90, Q640M8
    Conserved Domains (4) summary
    sd00017
    Location:361 → 380
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:416 → 438
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:402 → 425
    zf-H2C2_2; Zinc-finger double domain
    cl41771
    Location:1 → 357
    SP6-9_N; N-terminal domains of transcription factor Specificity Proteins (SP) 6-9, and similar proteins

  6. XM_011244124.4 → XP_011242426.1  transcription factor Sp8 isoform X1

    See identical proteins and their annotated locations for XP_011242426.1

    UniProtKB/Swiss-Prot
    Q8BMJ8, Q8BWA3
    UniProtKB/TrEMBL
    Q5QR90, Q640M8
    Conserved Domains (4) summary
    sd00017
    Location:361 → 380
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:416 → 438
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:402 → 425
    zf-H2C2_2; Zinc-finger double domain
    cl41771
    Location:1 → 357
    SP6-9_N; N-terminal domains of transcription factor Specificity Proteins (SP) 6-9, and similar proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BMJ8.1 GenPept UniProtKB/Swiss-Prot:Q8BMJ8

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