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Ptpn7 protein tyrosine phosphatase, non-receptor type 7 [ Mus musculus (house mouse) ]

Gene ID: 320139, updated on 11-Apr-2024

Summary

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Official Symbol
Ptpn7provided by MGI
Official Full Name
protein tyrosine phosphatase, non-receptor type 7provided by MGI
Primary source
MGI:MGI:2156893
See related
Ensembl:ENSMUSG00000031506 AllianceGenome:MGI:2156893
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
LPTP; HEPTP; BPTP-4; LC-PTP; C920001D21Rik
Summary
Predicted to enable protein tyrosine phosphatase activity. Acts upstream of or within protein dephosphorylation. Predicted to be located in cytoplasmic side of plasma membrane; cytosol; and mitotic spindle. Is expressed in liver and thymus primordium. Orthologous to human PTPN7 (protein tyrosine phosphatase non-receptor type 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in thymus adult (RPKM 47.9), spleen adult (RPKM 10.4) and 4 other tissues See more
Orthologs
human all
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Genomic context

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Location:
1 E4; 1 58.24 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (135059577..135073064)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (135131838..135145328)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1231 Neighboring gene ubiquitin-conjugating enzyme E2T Neighboring gene leucine-rich repeat-containing G protein-coupled receptor 6 Neighboring gene STARR-seq mESC enhancer starr_02346 Neighboring gene STARR-seq mESC enhancer starr_02347 Neighboring gene protein tyrosine phosphatase receptor type V Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:137029652-137029867 Neighboring gene STARR-positive B cell enhancer ABC_E9480 Neighboring gene ADP-ribosylation factor-like 8A Neighboring gene G protein-coupled receptor 37-like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Liver of MRL/lpr mice contain interleukin-4-producing lymphocytes and accessory cells that support the proliferation of Th2 helper T lymphocyte clones. Magilavy DB, et al. Eur J Immunol, 1992 Sep. PMID 1387611
  2. The protein tyrosine phosphatase PTPN7 is a negative regulator of ERK activation and thromboxane generation in platelets. Inamdar VV, et al. J Biol Chem, 2019 Aug 16. PMID 31266805, Free PMC Article
  3. Role of protein tyrosine phosphatase non-receptor type 7 in the regulation of TNF-α production in RAW 264.7 macrophages. Seo H, et al. PLoS One, 2013. PMID 24265715, Free PMC Article
  4. Hematopoietic protein tyrosine phosphatase suppresses extracellular stimulus-regulated kinase activation. Gronda M, et al. Mol Cell Biol, 2001 Oct. PMID 11564869, Free PMC Article
  5. Hematopoietic protein tyrosine phosphatase mediates beta2-adrenergic receptor-induced regulation of p38 mitogen-activated protein kinase in B lymphocytes. McAlees JW, et al. Mol Cell Biol, 2009 Feb. PMID 19047375, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PTPN7 regulates platelet functional responses downstream of GPCR agonists, but not GPVI agonists, through inhibition of ERK activation and thromboxane generation.
    Title: The protein tyrosine phosphatase PTPN7 is a negative regulator of ERK activation and thromboxane generation in platelets.
  2. PTPN7 as a negative regulator of TNF-alpha expression and the inflammatory response in macrophages
    Title: Role of protein tyrosine phosphatase non-receptor type 7 in the regulation of TNF-α production in RAW 264.7 macrophages.
  3. beta(2)AR stimulation on a B cell phosphorylates and inactivates HePTP in a Gs/cAMP/PKA-dependent manner to release bound p38 MAPK, making more available for phosphorylation and subsequent IgE regulation.
    Title: Hematopoietic protein tyrosine phosphatase mediates beta2-adrenergic receptor-induced regulation of p38 mitogen-activated protein kinase in B lymphocytes.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

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General gene information

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Homology

Clone Names

  • MGC107411

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tyrosine phosphatase activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein dephosphorylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic side of plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in mitotic spindle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
tyrosine-protein phosphatase non-receptor type 7
Names
hematopoietic protein-tyrosine phosphatase
NP_001343311.1
NP_796055.1
XP_006529759.1
XP_006529761.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356382.1 → NP_001343311.1  tyrosine-protein phosphatase non-receptor type 7

    Status: VALIDATED

    Source sequence(s)
    AC133097
    Consensus CDS
    CCDS15315.1
    UniProtKB/Swiss-Prot
    Q8BUM3
    UniProtKB/TrEMBL
    B7ZNE1
    Related
    ENSMUSP00000129474.2, ENSMUST00000167080.3
    Conserved Domains (1) summary
    cd14612
    Location:105 → 349
    PTPc-N7; catalytic domain of tyrosine-protein phosphatase non-receptor type 7

  2. NM_177081.4 → NP_796055.1  tyrosine-protein phosphatase non-receptor type 7

    See identical proteins and their annotated locations for NP_796055.1

    Status: VALIDATED

    Source sequence(s)
    AC133097
    Consensus CDS
    CCDS15315.1
    UniProtKB/Swiss-Prot
    Q8BUM3
    UniProtKB/TrEMBL
    B7ZNE1
    Related
    ENSMUSP00000045803.5, ENSMUST00000049449.11
    Conserved Domains (1) summary
    cd14612
    Location:105 → 349
    PTPc-N7; catalytic domain of tyrosine-protein phosphatase non-receptor type 7

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    135059577..135073064
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006529698.5 → XP_006529761.1  tyrosine-protein phosphatase non-receptor type 7 isoform X1

    See identical proteins and their annotated locations for XP_006529761.1

    UniProtKB/Swiss-Prot
    Q8BUM3
    UniProtKB/TrEMBL
    B7ZNE1
    Conserved Domains (1) summary
    cd14612
    Location:105 → 349
    PTPc-N7; catalytic domain of tyrosine-protein phosphatase non-receptor type 7

  2. XM_006529696.5 → XP_006529759.1  tyrosine-protein phosphatase non-receptor type 7 isoform X1

    See identical proteins and their annotated locations for XP_006529759.1

    UniProtKB/Swiss-Prot
    Q8BUM3
    UniProtKB/TrEMBL
    B7ZNE1
    Related
    ENSMUSP00000141133.2, ENSMUST00000187985.7
    Conserved Domains (1) summary
    cd14612
    Location:105 → 349
    PTPc-N7; catalytic domain of tyrosine-protein phosphatase non-receptor type 7
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BUM3.1 GenPept UniProtKB/Swiss-Prot:Q8BUM3

Gene LinkOut

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