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Grk3 G protein-coupled receptor kinase 3 [ Mus musculus (house mouse) ]

Gene ID: 320129, updated on 11-Apr-2024

Summary

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Official Symbol
Grk3provided by MGI
Official Full Name
G protein-coupled receptor kinase 3provided by MGI
Primary source
MGI:MGI:87941
See related
Ensembl:ENSMUSG00000042249 AllianceGenome:MGI:87941
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Adrbk2; Bark-2; Adrbk-2; 4833444A01Rik
Summary
Enables G protein-coupled receptor kinase activity. Predicted to be involved in several processes, including cellular protein metabolic process; desensitization of G protein-coupled receptor signaling pathway; and inositol phosphate metabolic process. Predicted to act upstream of or within phosphorylation. Predicted to be located in several cellular components, including Z disc; dendrite; and sperm midpiece. Is expressed in adrenal gland; alimentary system; nervous system; retina; and vibrissa. Orthologous to human GRK3 (G protein-coupled receptor kinase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in frontal lobe adult (RPKM 7.8), cerebellum adult (RPKM 7.5) and 26 other tissues See more
Orthologs
human all
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Genomic context

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Location:
5 F; 5 55.29 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (113058344..113163518, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (112910478..113015660, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene VISTA enhancer mm1731 Neighboring gene predicted gene, 30529 Neighboring gene STARR-seq mESC enhancer starr_14014 Neighboring gene myosin XVIIIb Neighboring gene RIKEN cDNA 1700095B10 gene Neighboring gene STARR-seq mESC enhancer starr_14016 Neighboring gene predicted gene, 22740 Neighboring gene predicted gene 43247 Neighboring gene crystallin, beta B2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. G protein-coupled receptor kinase 3 (GRK3) gene disruption leads to loss of odorant receptor desensitization. Peppel K, et al. J Biol Chem, 1997 Oct 10. PMID 9325250
  2. Aged G Protein-Coupled Receptor Kinase 3 (Grk3)-Deficient Mice Exhibit Enhanced Osteoclastogenesis and Develop Bone Lesions Analogous to Human Paget's Disease of Bone. Rabjohns EM, et al. Cells, 2023 Mar 23. PMID 37048054, Free PMC Article
  3. G protein-coupled receptor kinase 3 modulates mesenchymal stem cell proliferation and differentiation through sphingosine-1-phosphate receptor regulation. Brozowski JM, et al. Stem Cell Res Ther, 2022 Jan 29. PMID 35093170, Free PMC Article
  4. Estrogen Regulation of GRK2 Inactivates Kappa Opioid Receptor Signaling Mediating Analgesia, But Not Aversion. Abraham AD, et al. J Neurosci, 2018 Sep 12. PMID 30076211, Free PMC Article
  5. G protein-coupled receptor kinase-3-deficient mice exhibit WHIM syndrome features and attenuated inflammatory responses. Tarrant TK, et al. J Leukoc Biol, 2013 Dec. PMID 23935208, Free PMC Article

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Aged G Protein-Coupled Receptor Kinase 3 (Grk3)-Deficient Mice Exhibit Enhanced Osteoclastogenesis and Develop Bone Lesions Analogous to Human Paget's Disease of Bone.
    Title: Aged G Protein-Coupled Receptor Kinase 3 (Grk3)-Deficient Mice Exhibit Enhanced Osteoclastogenesis and Develop Bone Lesions Analogous to Human Paget's Disease of Bone.
  2. G protein-coupled receptor kinase 3 modulates mesenchymal stem cell proliferation and differentiation through sphingosine-1-phosphate receptor regulation.
    Title: G protein-coupled receptor kinase 3 modulates mesenchymal stem cell proliferation and differentiation through sphingosine-1-phosphate receptor regulation.
  3. GRK3 controls cardiac alpha1-adrenergic receptor responsiveness
    Title: Cardiac-restricted expression of the carboxyl-terminal fragment of GRK3 Uncovers Distinct Functions of GRK3 in regulation of cardiac contractility and growth: GRK3 controls cardiac alpha1-adrenergic receptor responsiveness.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables D1 dopamine receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables G protein-coupled receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled receptor kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled receptor kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables G protein-coupled receptor kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables beta-adrenergic receptor kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in desensitization of G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in desensitization of G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in inositol phosphate metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular protein transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in receptor internalization ISO
Inferred from Sequence Orthology
more info
  
involved_in rhodopsin metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Z disc ISO
Inferred from Sequence Orthology
more info
  
located_in axon ISO
Inferred from Sequence Orthology
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in dendrite terminus ISO
Inferred from Sequence Orthology
more info
  
located_in dendritic shaft ISO
Inferred from Sequence Orthology
more info
  
located_in dendritic spine ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
  
is_active_in presynapse ISO
Inferred from Sequence Orthology
more info
  
located_in sperm midpiece ISO
Inferred from Sequence Orthology
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
G protein-coupled receptor kinase 3
Names
adrenergic receptor kinase, beta 2
beta ARK2
beta-ARK-2
beta-adrenergic receptor kinase 2
NP_001272735.1
NP_796052.2
XP_036021101.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001285806.1 → NP_001272735.1  G protein-coupled receptor kinase 3 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 5' region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 3, which is shorter at the N-terminus, compared to isoform 1.
    Source sequence(s)
    AI851927, AK076533, AK134672, AK141186, CJ104587
    UniProtKB/TrEMBL
    Q8BVT9
    Conserved Domains (5) summary
    cd01240
    Location:446 → 563
    PH_GRK2_subgroup; G Protein-Coupled Receptor Kinase 2 subgroup pleckstrin homology (PH) domain
    pfam00069
    Location:84 → 346
    Pkinase; Protein kinase domain
    pfam00169
    Location:453 → 540
    PH; PH domain
    cl02565
    Location:1 → 79
    RGS; Regulator of G protein signaling (RGS) domain superfamily
    cl21453
    Location:78 → 423
    PKc_like; Protein Kinases, catalytic domain

  2. NM_177078.4 → NP_796052.2  G protein-coupled receptor kinase 3 isoform 1

    See identical proteins and their annotated locations for NP_796052.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AI851927, AK076533, AK134672, CJ104587
    Consensus CDS
    CCDS19545.1
    UniProtKB/Swiss-Prot
    F8VPM8, Q3UYH7
    UniProtKB/TrEMBL
    Q8BVT9
    Related
    ENSMUSP00000070445.5, ENSMUST00000065167.9
    Conserved Domains (5) summary
    cd08747
    Location:30 → 186
    RGS_GRK2_GRK3; Regulator of G protein signaling domain (RGS) found in G protein-coupled receptor kinase 2 (GRK2) and G protein-coupled receptor kinase 3 (GRK3)
    cd01240
    Location:553 → 670
    PH_GRK2_subgroup; G Protein-Coupled Receptor Kinase 2 subgroup pleckstrin homology (PH) domain
    pfam00069
    Location:191 → 453
    Pkinase; Protein kinase domain
    pfam00169
    Location:560 → 647
    PH; PH domain
    cl21453
    Location:185 → 530
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    113058344..113163518 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036165208.1 → XP_036021101.1  G protein-coupled receptor kinase 3 isoform X1

    Conserved Domains (3) summary
    cd08747
    Location:30 → 186
    RGS_GRK2_GRK3; Regulator of G protein signaling domain (RGS) found in G protein-coupled receptor kinase 2 (GRK2) and G protein-coupled receptor kinase 3 (GRK3)
    cd01240
    Location:517 → 634
    PH_GRK2_subgroup; G Protein-Coupled Receptor Kinase 2 subgroup pleckstrin homology (PH) domain
    cl21453
    Location:185 → 494
    PKc_like; Protein Kinases, catalytic domain

RNA

  1. XR_389274.5 RNA Sequence

  2. XR_880393.4 RNA Sequence

  3. XR_880394.4 RNA Sequence

  4. XR_004942525.1 RNA Sequence

  5. XR_003955659.2 RNA Sequence

  6. XR_389275.5 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001035531.1: Suppressed sequence

    Description
    NM_001035531.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3UYH7.2 GenPept UniProtKB/Swiss-Prot:Q3UYH7

Gene LinkOut

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