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Rps6kc1 ribosomal protein S6 kinase polypeptide 1 [ Mus musculus (house mouse) ]

Gene ID: 320119, updated on 30-Apr-2024

Summary

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Official Symbol
Rps6kc1provided by MGI
Official Full Name
ribosomal protein S6 kinase polypeptide 1provided by MGI
Primary source
MGI:MGI:2443419
See related
Ensembl:ENSMUSG00000089872 AllianceGenome:MGI:2443419
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rpk118; B130003F20Rik
Summary
Predicted to enable ATP binding activity; phosphatidylinositol binding activity; and protein serine/threonine kinase activity. Predicted to be involved in protein phosphorylation. Predicted to act upstream of or within phosphorylation. Is active in postsynaptic density. Is expressed in olfactory epithelium and vomeronasal organ. Orthologous to human RPS6KC1 (ribosomal protein S6 kinase C1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cortex adult (RPKM 3.4), CNS E14 (RPKM 3.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
1 H6; 1 96.2 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (190505076..190645207, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (190772879..190913010, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 38452 Neighboring gene STARR-seq mESC enhancer starr_03419 Neighboring gene predicted gene, 39738 Neighboring gene STARR-seq mESC enhancer starr_03421 Neighboring gene predicted gene, 51740 Neighboring gene STARR-positive B cell enhancer mm9_chr1:192705345-192705646 Neighboring gene STARR-positive B cell enhancer ABC_E3353 Neighboring gene angel homolog 2 Neighboring gene predicted gene, 53493 Neighboring gene vasohibin 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. In-depth protein profiling of the postsynaptic density from mouse hippocampus using data-independent acquisition proteomics. Distler U, et al. Proteomics, 2014 Nov. PMID 25211037
  2. Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics. Federspiel JD, et al. Mol Cell Proteomics, 2019 Aug 9. PMID 31040226, Free PMC Article
  3. Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies. Murtaza N, et al. Cell Rep, 2022 Nov 22. PMID 36417873
  4. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
  5. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Gene trapped (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in early endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in early endosome ISO
Inferred from Sequence Orthology
more info
  
located_in endosome ISO
Inferred from Sequence Orthology
more info
  
located_in lysosome ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in postsynaptic density EXP
Inferred from Experiment
more info
 PubMed 
is_active_in postsynaptic density IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
ribosomal protein S6 kinase delta-1
Names
52 kDa ribosomal protein S6 kinase
S6K-delta-1
ribosomal protein S6 kinase, 52kDa, polypeptide 1
NP_848890.3
XP_006497235.1
XP_006497236.1
XP_006497237.1
XP_006497238.1
XP_011237223.1
XP_030110821.1
XP_030110822.1
XP_036021590.1
XP_036021591.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178775.4 → NP_848890.3  ribosomal protein S6 kinase delta-1

    Status: VALIDATED

    Source sequence(s)
    AK149858, BC058403, BG079911, CJ045347
    UniProtKB/Swiss-Prot
    Q3UDY3, Q6PDY4, Q8BLK9, Q8BMQ5, Q8BX49
    UniProtKB/TrEMBL
    E9QMX4
    Related
    ENSMUSP00000061769.9, ENSMUST00000061611.15
    Conserved Domains (5) summary
    cd07287
    Location:11 → 128
    PX_RPK118_like; The phosphoinositide binding Phox Homology domain of RPK118-like proteins
    smart00220
    Location:864 → 1046
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd02677
    Location:237 → 309
    MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
    cd05576
    Location:869 → 1046
    STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
    cl21453
    Location:334 → 427
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    190505076..190645207 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006497172.4 → XP_006497235.1  ribosomal protein S6 kinase delta-1 isoform X1

    UniProtKB/Swiss-Prot
    Q3UDY3, Q6PDY4, Q8BLK9, Q8BMQ5, Q8BX49
    Conserved Domains (4) summary
    cd02677
    Location:225 → 297
    MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
    cd05576
    Location:857 → 1034
    STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
    cl02563
    Location:11 → 116
    PX_domain; The Phox Homology domain, a phosphoinositide binding module
    cl21453
    Location:322 → 415
    PKc_like; Protein Kinases, catalytic domain

  2. XM_006497175.4 → XP_006497238.1  ribosomal protein S6 kinase delta-1 isoform X4

    UniProtKB/Swiss-Prot
    Q3UDY3, Q6PDY4, Q8BLK9, Q8BMQ5, Q8BX49
    Conserved Domains (4) summary
    cd07287
    Location:11 → 128
    PX_RPK118_like; The phosphoinositide binding Phox Homology domain of RPK118-like proteins
    cd05576
    Location:749 → 926
    STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
    cl00299
    Location:155 → 189
    MIT; domain contained within Microtubule Interacting and Trafficking molecules. The MIT domain is found in sorting nexins, the nuclear thiol protease PalBH, the AAA protein spastin and archaebacterial proteins with similar domain architecture, vacuolar ...
    cl21453
    Location:214 → 307
    PKc_like; Protein Kinases, catalytic domain

  3. XM_006497173.4 → XP_006497236.1  ribosomal protein S6 kinase delta-1 isoform X2

    UniProtKB/Swiss-Prot
    Q3UDY3, Q6PDY4, Q8BLK9, Q8BMQ5, Q8BX49
    Conserved Domains (4) summary
    cd07287
    Location:11 → 128
    PX_RPK118_like; The phosphoinositide binding Phox Homology domain of RPK118-like proteins
    cd02677
    Location:237 → 309
    MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
    cd05576
    Location:838 → 1015
    STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
    cl21453
    Location:305 → 396
    PKc_like; Protein Kinases, catalytic domain

  4. XM_006497174.4 → XP_006497237.1  ribosomal protein S6 kinase delta-1 isoform X3

    UniProtKB/Swiss-Prot
    Q3UDY3, Q6PDY4, Q8BLK9, Q8BMQ5, Q8BX49
    Conserved Domains (3) summary
    cd07287
    Location:11 → 128
    PX_RPK118_like; The phosphoinositide binding Phox Homology domain of RPK118-like proteins
    cd02677
    Location:237 → 309
    MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
    cl21453
    Location:869 → 960
    PKc_like; Protein Kinases, catalytic domain

  5. XM_030254962.1 → XP_030110822.1  ribosomal protein S6 kinase delta-1 isoform X6

    Conserved Domains (3) summary
    cd02677
    Location:56 → 128
    MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
    cd05576
    Location:657 → 834
    STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
    cl21453
    Location:124 → 215
    PKc_like; Protein Kinases, catalytic domain

  6. XM_030254961.1 → XP_030110821.1  ribosomal protein S6 kinase delta-1 isoform X5

    UniProtKB/Swiss-Prot
    Q3UDY3, Q6PDY4, Q8BLK9, Q8BMQ5, Q8BX49
    Conserved Domains (3) summary
    cd02677
    Location:56 → 128
    MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
    cd05576
    Location:688 → 865
    STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
    cl21453
    Location:153 → 246
    PKc_like; Protein Kinases, catalytic domain

  7. XM_011238921.2 → XP_011237223.1  ribosomal protein S6 kinase delta-1 isoform X5

    UniProtKB/Swiss-Prot
    Q3UDY3, Q6PDY4, Q8BLK9, Q8BMQ5, Q8BX49
    Conserved Domains (3) summary
    cd02677
    Location:56 → 128
    MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
    cd05576
    Location:688 → 865
    STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
    cl21453
    Location:153 → 246
    PKc_like; Protein Kinases, catalytic domain

  8. XM_036165697.1 → XP_036021590.1  ribosomal protein S6 kinase delta-1 isoform X5

    UniProtKB/Swiss-Prot
    Q3UDY3, Q6PDY4, Q8BLK9, Q8BMQ5, Q8BX49
    Conserved Domains (3) summary
    cd02677
    Location:56 → 128
    MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
    cd05576
    Location:688 → 865
    STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
    cl21453
    Location:153 → 246
    PKc_like; Protein Kinases, catalytic domain

  9. XM_036165698.1 → XP_036021591.1  ribosomal protein S6 kinase delta-1 isoform X7

    Conserved Domains (1) summary
    cd05576
    Location:434 → 611
    STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins

RNA

  1. XR_004942884.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BLK9.2 GenPept UniProtKB/Swiss-Prot:Q8BLK9

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