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Relt RELT tumor necrosis factor receptor [ Mus musculus (house mouse) ]

Gene ID: 320100, updated on 18-Apr-2024

Summary

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Official Symbol
Reltprovided by MGI
Official Full Name
RELT tumor necrosis factor receptorprovided by MGI
Primary source
MGI:MGI:2443373
See related
Ensembl:ENSMUSG00000008318 AllianceGenome:MGI:2443373
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tnfrsf19l; E430021K24Rik
Summary
Involved in amelogenesis. Predicted to be located in nucleoplasm. Is expressed in female associated reproductive structure and urethra of female. Used to study amelogenesis imperfecta. Human ortholog(s) of this gene implicated in amelogenesis imperfecta type 3C. Orthologous to human RELT (RELT TNF receptor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in spleen adult (RPKM 9.5), thymus adult (RPKM 6.5) and 24 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 E2; 7 54.44 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (100495054..100512690, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (100845847..100863489, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 35082 Neighboring gene STARR-seq mESC enhancer starr_19675 Neighboring gene STARR-seq mESC enhancer starr_19676 Neighboring gene family with sequence similarity 168, member A Neighboring gene STARR-seq mESC enhancer starr_19677 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E2834 Neighboring gene STARR-positive B cell enhancer ABC_E4955 Neighboring gene Rho guanine nucleotide exchange factor 17 Neighboring gene STARR-positive B cell enhancer ABC_E8191 Neighboring gene microRNA 3102 Neighboring gene STARR-seq mESC enhancer starr_19682 Neighboring gene STARR-seq mESC enhancer starr_19683 Neighboring gene pyrimidinergic receptor P2Y, G-protein coupled, 6 Neighboring gene STARR-seq mESC enhancer starr_19684

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. RELT negatively regulates the early phase of the T-cell response in mice. Choi BK, et al. Eur J Immunol, 2018 Oct. PMID 30138536
  2. Mutations in RELT cause autosomal recessive amelogenesis imperfecta. Kim JW, et al. Clin Genet, 2019 Mar. PMID 30506946, Free PMC Article
  3. Comparative analysis of apoptosis and inflammation genes of mice and humans. Reed JC, et al. Genome Res, 2003 Jun. PMID 12819136, Free PMC Article
  4. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
  5. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in amelogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in amelogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in amelogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in apoptotic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within programmed cell death RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
tumor necrosis factor receptor superfamily member 19L

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001358914.1 → NP_001345843.1  tumor necrosis factor receptor superfamily member 19L isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC150744
    Conserved Domains (2) summary
    cd13419
    Location:73 → 159
    TNFRSF19L; tumor necrosis factor receptor superfamily member 19-like (TNFRSF19L), also known as receptor expressed in lymphoid tissues (RELT)
    pfam12606
    Location:210 → 245
    RELT; tumor necrosis factor receptor superfamily member 19

  2. NM_177073.6 → NP_796047.2  tumor necrosis factor receptor superfamily member 19L isoform 1 precursor

    See identical proteins and their annotated locations for NP_796047.2

    Status: VALIDATED

    Source sequence(s)
    AC150744
    Consensus CDS
    CCDS21506.1
    UniProtKB/Swiss-Prot
    Q497Z8, Q8BTV0, Q8BX43
    Related
    ENSMUSP00000008462.4, ENSMUST00000008462.11
    Conserved Domains (2) summary
    cd13419
    Location:33 → 119
    TNFRSF19L; tumor necrosis factor receptor superfamily member 19-like (TNFRSF19L), also known as receptor expressed in lymphoid tissues (RELT)
    pfam12606
    Location:170 → 205
    RELT; tumor necrosis factor receptor superfamily member 19

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    100495054..100512690 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006507940.5 → XP_006508003.1  tumor necrosis factor receptor superfamily member 19L isoform X3

    Conserved Domains (2) summary
    cd13419
    Location:73 → 159
    TNFRSF19L; tumor necrosis factor receptor superfamily member 19-like (TNFRSF19L), also known as receptor expressed in lymphoid tissues (RELT)
    pfam12606
    Location:210 → 245
    RELT; tumor necrosis factor receptor superfamily member 19

  2. XM_030242675.2 → XP_030098535.1  tumor necrosis factor receptor superfamily member 19L isoform X5

    Conserved Domains (2) summary
    cd13419
    Location:33 → 119
    TNFRSF19L; tumor necrosis factor receptor superfamily member 19-like (TNFRSF19L), also known as receptor expressed in lymphoid tissues (RELT)
    pfam12606
    Location:170 → 205
    RELT; tumor necrosis factor receptor superfamily member 19

  3. XM_006507939.5 → XP_006508002.1  tumor necrosis factor receptor superfamily member 19L isoform X2

    Conserved Domains (2) summary
    cd13419
    Location:73 → 159
    TNFRSF19L; tumor necrosis factor receptor superfamily member 19-like (TNFRSF19L), also known as receptor expressed in lymphoid tissues (RELT)
    pfam12606
    Location:210 → 245
    RELT; tumor necrosis factor receptor superfamily member 19

  4. XM_030242674.2 → XP_030098534.1  tumor necrosis factor receptor superfamily member 19L isoform X4

    Conserved Domains (2) summary
    cd13419
    Location:33 → 119
    TNFRSF19L; tumor necrosis factor receptor superfamily member 19-like (TNFRSF19L), also known as receptor expressed in lymphoid tissues (RELT)
    pfam12606
    Location:170 → 205
    RELT; tumor necrosis factor receptor superfamily member 19

  5. XM_006507933.3 → XP_006507996.1  tumor necrosis factor receptor superfamily member 19L isoform X1

    See identical proteins and their annotated locations for XP_006507996.1

    UniProtKB/Swiss-Prot
    Q497Z8, Q8BTV0, Q8BX43
    Conserved Domains (2) summary
    cd13419
    Location:33 → 119
    TNFRSF19L; tumor necrosis factor receptor superfamily member 19-like (TNFRSF19L), also known as receptor expressed in lymphoid tissues (RELT)
    pfam12606
    Location:170 → 205
    RELT; tumor necrosis factor receptor superfamily member 19

  6. XM_006507932.5 → XP_006507995.1  tumor necrosis factor receptor superfamily member 19L isoform X1

    See identical proteins and their annotated locations for XP_006507995.1

    UniProtKB/Swiss-Prot
    Q497Z8, Q8BTV0, Q8BX43
    Conserved Domains (2) summary
    cd13419
    Location:33 → 119
    TNFRSF19L; tumor necrosis factor receptor superfamily member 19-like (TNFRSF19L), also known as receptor expressed in lymphoid tissues (RELT)
    pfam12606
    Location:170 → 205
    RELT; tumor necrosis factor receptor superfamily member 19

  7. XM_006507935.4 → XP_006507998.1  tumor necrosis factor receptor superfamily member 19L isoform X1

    See identical proteins and their annotated locations for XP_006507998.1

    UniProtKB/Swiss-Prot
    Q497Z8, Q8BTV0, Q8BX43
    Conserved Domains (2) summary
    cd13419
    Location:33 → 119
    TNFRSF19L; tumor necrosis factor receptor superfamily member 19-like (TNFRSF19L), also known as receptor expressed in lymphoid tissues (RELT)
    pfam12606
    Location:170 → 205
    RELT; tumor necrosis factor receptor superfamily member 19

  8. XM_006507934.5 → XP_006507997.1  tumor necrosis factor receptor superfamily member 19L isoform X1

    See identical proteins and their annotated locations for XP_006507997.1

    UniProtKB/Swiss-Prot
    Q497Z8, Q8BTV0, Q8BX43
    Conserved Domains (2) summary
    cd13419
    Location:33 → 119
    TNFRSF19L; tumor necrosis factor receptor superfamily member 19-like (TNFRSF19L), also known as receptor expressed in lymphoid tissues (RELT)
    pfam12606
    Location:170 → 205
    RELT; tumor necrosis factor receptor superfamily member 19

  9. XM_006507931.5 → XP_006507994.1  tumor necrosis factor receptor superfamily member 19L isoform X1

    See identical proteins and their annotated locations for XP_006507994.1

    UniProtKB/Swiss-Prot
    Q497Z8, Q8BTV0, Q8BX43
    Conserved Domains (2) summary
    cd13419
    Location:33 → 119
    TNFRSF19L; tumor necrosis factor receptor superfamily member 19-like (TNFRSF19L), also known as receptor expressed in lymphoid tissues (RELT)
    pfam12606
    Location:170 → 205
    RELT; tumor necrosis factor receptor superfamily member 19

  10. XM_006507936.5 → XP_006507999.1  tumor necrosis factor receptor superfamily member 19L isoform X1

    See identical proteins and their annotated locations for XP_006507999.1

    UniProtKB/Swiss-Prot
    Q497Z8, Q8BTV0, Q8BX43
    Conserved Domains (2) summary
    cd13419
    Location:33 → 119
    TNFRSF19L; tumor necrosis factor receptor superfamily member 19-like (TNFRSF19L), also known as receptor expressed in lymphoid tissues (RELT)
    pfam12606
    Location:170 → 205
    RELT; tumor necrosis factor receptor superfamily member 19

RNA

  1. XR_378249.5 RNA Sequence

  2. XR_003946489.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BX43.2 GenPept UniProtKB/Swiss-Prot:Q8BX43

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