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Sidt1 SID1 transmembrane family, member 1 [ Mus musculus (house mouse) ]

Gene ID: 320007, updated on 21-Apr-2024

Summary

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Official Symbol
Sidt1provided by MGI
Official Full Name
SID1 transmembrane family, member 1provided by MGI
Primary source
MGI:MGI:2443155
See related
Ensembl:ENSMUSG00000022696 AllianceGenome:MGI:2443155
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
B830021E24Rik
Summary
Enables double-stranded RNA binding activity. Predicted to be involved in RNA transport. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in lysosome and plasma membrane. Is expressed in intestine and male reproductive gland or organ. Orthologous to human SIDT1 (SID1 transmembrane family member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cortex adult (RPKM 11.4), bladder adult (RPKM 10.6) and 16 other tissues See more
Orthologs
human all
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Genomic context

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Location:
16 B4; 16 28.57 cM
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (44060540..44153575, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (44240177..44333212, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_40895 Neighboring gene STARR-positive B cell enhancer ABC_E9932 Neighboring gene STARR-seq mESC enhancer starr_40896 Neighboring gene STARR-positive B cell enhancer ABC_E11613 Neighboring gene STARR-positive B cell enhancer ABC_E2462 Neighboring gene N(alpha)-acetyltransferase 50, NatE catalytic subunit Neighboring gene upstream transcription factor family member 3 Neighboring gene STARR-seq mESC enhancer starr_40897 Neighboring gene STARR-seq mESC enhancer starr_40898 Neighboring gene STARR-seq mESC enhancer starr_40899 Neighboring gene spindle and centriole associated protein 1 Neighboring gene STARR-seq mESC enhancer starr_40902 Neighboring gene cilia and flagella associated protein 44 Neighboring gene STARR-seq mESC enhancer starr_40903 Neighboring gene STARR-seq mESC enhancer starr_40904

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. SIDT1 plays a key role in type I IFN responses to nucleic acids in plasmacytoid dendritic cells and mediates the pathogenesis of an imiquimod-induced psoriasis model. Morell M, et al. EBioMedicine, 2022 Feb. PMID 35065421, Free PMC Article
  2. Honeysuckle-derived microRNA2911 inhibits tumor growth by targeting TGF-β1. Liu C, et al. Chin Med, 2021 Jun 29. PMID 34187513, Free PMC Article
  3. SIDT1-dependent absorption in the stomach mediates host uptake of dietary and orally administered microRNAs. Chen Q, et al. Cell Res, 2021 Mar. PMID 32801357, Free PMC Article
  4. SIDT1 Localizes to Endolysosomes and Mediates Double-Stranded RNA Transport into the Cytoplasm. Nguyen TA, et al. J Immunol, 2019 Jun 15. PMID 31061008
  5. Systemic RNA Interference Deficiency-1 (SID-1) Extracellular Domain Selectively Binds Long Double-stranded RNA and Is Required for RNA Transport by SID-1. Li W, et al. J Biol Chem, 2015 Jul 31. PMID 26067272, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cholesterol binding ISO
Inferred from Sequence Orthology
more info
  
enables double-stranded RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables double-stranded RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in RNA transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in lysosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
SID1 transmembrane family member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159419.1 → NP_001152891.1  SID1 transmembrane family member 1 isoform 1 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK034344, AY562214, BC079584
    Consensus CDS
    CCDS49853.1
    UniProtKB/TrEMBL
    E9Q247
    Related
    ENSMUSP00000038433.7, ENSMUST00000047446.13
    Conserved Domains (1) summary
    pfam13965
    Location:187 → 811
    SID-1_RNA_chan; dsRNA-gated channel SID-1

  2. NM_198034.3 → NP_932151.2  SID1 transmembrane family member 1 isoform 2 precursor

    See identical proteins and their annotated locations for NP_932151.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    BC079584
    Consensus CDS
    CCDS28185.1
    UniProtKB/Swiss-Prot
    Q6AXF6, Q8R397
    Related
    ENSMUSP00000115372.2, ENSMUST00000136381.8
    Conserved Domains (1) summary
    pfam13965
    Location:187 → 806
    SID-1_RNA_chan; dsRNA-gated channel SID-1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    44060540..44153575 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006522237.2 → XP_006522300.1  SID1 transmembrane family member 1 isoform X2

    Conserved Domains (1) summary
    pfam13965
    Location:1 → 591
    SID-1_RNA_chan; dsRNA-gated channel SID-1

  2. XM_017317034.2 → XP_017172523.1  SID1 transmembrane family member 1 isoform X1

    Conserved Domains (1) summary
    pfam13965
    Location:127 → 754
    SID-1_RNA_chan; dsRNA-gated channel SID-1

RNA

  1. XR_875822.3 RNA Sequence

  2. XR_384572.4 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6AXF6.1 GenPept UniProtKB/Swiss-Prot:Q6AXF6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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