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Taf2 TATA-box binding protein associated factor 2 [ Mus musculus (house mouse) ]

Gene ID: 319944, updated on 5-Mar-2024

Summary

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Official Symbol
Taf2provided by MGI
Official Full Name
TATA-box binding protein associated factor 2provided by MGI
Primary source
MGI:MGI:2443028
See related
Ensembl:ENSMUSG00000037343 AllianceGenome:MGI:2443028
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TAF2B; CIF150; TAFII150; TAFII-150; 4732460C16Rik
Summary
Predicted to enable chromatin binding activity and transcription cis-regulatory region binding activity. Predicted to contribute to RNA polymerase II general transcription initiation factor activity. Predicted to be involved in G2/M transition of mitotic cell cycle and transcription initiation from RNA polymerase II promoter. Predicted to be located in nucleus. Predicted to be part of transcription factor TFIID complex and transcription factor TFTC complex. Is expressed in tail. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability. Orthologous to human TAF2 (TATA-box binding protein associated factor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 13.6), CNS E14 (RPKM 10.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
15 D1; 15 21.96 cM
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (54878525..54935580, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (55015129..55072187, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_38694 Neighboring gene predicted gene, 26684 Neighboring gene predicted gene 2491 Neighboring gene STARR-positive B cell enhancer mm9_chr15:54903568-54903869 Neighboring gene DNA replication and sister chromatid cohesion 1 Neighboring gene predicted gene, 41325 Neighboring gene STARR-positive B cell enhancer ABC_E3139 Neighboring gene predicted gene 9920 Neighboring gene DEP domain containing MTOR-interacting protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. TAF8 regions important for TFIID lobe B assembly or for TAF2 interactions are required for embryonic stem cell survival. Scheer E, et al. J Biol Chem, 2021 Nov. PMID 34634302, Free PMC Article
  2. Isolation of differentially expressed genes from wild-type and Twist mutant mouse limb buds. Loebel DA, et al. Genesis, 2002 Jul. PMID 12124942
  3. UV-damaged DNA-binding protein in the TFTC complex links DNA damage recognition to nucleosome acetylation. Brand M, et al. EMBO J, 2001 Jun 15. PMID 11406595, Free PMC Article
  4. The TBN protein, which is essential for early embryonic mouse development, is an inducible TAFII implicated in adipogenesis. Guermah M, et al. Mol Cell, 2003 Oct. PMID 14580349
  5. Identification of TATA-binding protein-free TAFII-containing complex subunits suggests a role in nucleosome acetylation and signal transduction. Brand M, et al. J Biol Chem, 1999 Jun 25. PMID 10373431

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TAF8 regions important for TFIID lobe B assembly or for TAF2 interactions are required for embryonic stem cell survival.
    Title: TAF8 regions important for TFIID lobe B assembly or for TAF2 interactions are required for embryonic stem cell survival.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
contributes_to RNA polymerase II general transcription initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription cis-regulatory region binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription cis-regulatory region binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in G2/M transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in RNA polymerase II preinitiation complex assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in mRNA transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of transcription initiation by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA repair NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in transcription initiation at RNA polymerase II promoter IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transcription initiation at RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of transcription factor TFIID complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transcription factor TFIID complex ISO
Inferred from Sequence Orthology
more info
 PubMed 
part_of transcription factor TFTC complex ISO
Inferred from Sequence Orthology
more info
  
part_of transcription factor TFTC complex NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
transcription initiation factor TFIID subunit 2
Names
TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor
TBP-associated factor 150 kDa
transcription initiation factor TFIID 150 kDa subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081288.1 → NP_001074757.1  transcription initiation factor TFIID subunit 2

    See identical proteins and their annotated locations for NP_001074757.1

    Status: VALIDATED

    Source sequence(s)
    AC137950
    Consensus CDS
    CCDS37075.1
    UniProtKB/Swiss-Prot
    Q8BKQ7, Q8C176
    UniProtKB/TrEMBL
    B9EJX5
    Related
    ENSMUSP00000043733.8, ENSMUST00000041733.9
    Conserved Domains (1) summary
    cd09839
    Location:27 → 541
    M1_TAF2; TATA binding protein (TBP) associated factor 2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    54878525..54935580 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011245657.4 → XP_011243959.1  transcription initiation factor TFIID subunit 2 isoform X1

    UniProtKB/Swiss-Prot
    Q8BKQ7, Q8C176
    Conserved Domains (1) summary
    cd09839
    Location:28 → 527
    M1_like_TAF2; TATA binding protein (TBP) associated factor 2

  2. XM_006521076.5 → XP_006521139.1  transcription initiation factor TFIID subunit 2 isoform X2

    UniProtKB/Swiss-Prot
    Q8BKQ7, Q8C176
    Conserved Domains (1) summary
    cd09839
    Location:28 → 523
    M1_like_TAF2; TATA binding protein (TBP) associated factor 2

RNA

  1. XR_001781544.3 RNA Sequence

  2. XR_001781543.3 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_177040.3: Suppressed sequence

    Description
    NM_177040.3: This RefSeq was removed because it was based on a cloning artifact.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8C176.2 GenPept UniProtKB/Swiss-Prot:Q8C176

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