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Vwc2 von Willebrand factor C domain containing 2 [ Mus musculus (house mouse) ]

Gene ID: 319922, updated on 11-Apr-2024

Summary

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Official Symbol
Vwc2provided by MGI
Official Full Name
von Willebrand factor C domain containing 2provided by MGI
Primary source
MGI:MGI:2442987
See related
Ensembl:ENSMUSG00000050830 AllianceGenome:MGI:2442987
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
G11; UNQ739; cradin; PSST739; A930041G11Rik
Summary
Involved in negative regulation of BMP signaling pathway and positive regulation of neuron differentiation. Acts upstream of or within positive regulation of cell-substrate adhesion. Located in basement membrane; extracellular space; and interstitial matrix. Part of AMPA glutamate receptor complex. Is expressed in alimentary system; blood vessel; and nervous system. Orthologous to human VWC2 (von Willebrand factor C domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
human all
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Genomic context

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Location:
11 A1; 11 6.27 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (11063836..11219295)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (11113868..11269295)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_28579 Neighboring gene STARR-seq mESC enhancer starr_28580 Neighboring gene ribosomal protein L36a, related sequence 8 Neighboring gene 60S ribosomal protein L36 pseudogene Neighboring gene STARR-seq mESC enhancer starr_28581 Neighboring gene STARR-seq mESC enhancer starr_28583 Neighboring gene STARR-seq mESC enhancer starr_28584 Neighboring gene STARR-seq mESC enhancer starr_28585 Neighboring gene STARR-seq mESC enhancer starr_28586 Neighboring gene STARR-seq mESC enhancer starr_28587 Neighboring gene STARR-seq mESC enhancer starr_28588 Neighboring gene STARR-seq mESC enhancer starr_28589 Neighboring gene STARR-seq mESC enhancer starr_28590 Neighboring gene STARR-seq mESC enhancer starr_28591 Neighboring gene STARR-seq mESC enhancer starr_28592 Neighboring gene STARR-seq mESC enhancer starr_28593 Neighboring gene STARR-seq mESC enhancer starr_28594 Neighboring gene predicted gene, 39578 Neighboring gene BRCA1/BRCA2-containing complex, subunit 3 pseudogene Neighboring gene zona pellucida binding protein Neighboring gene STARR-seq mESC enhancer starr_28595 Neighboring gene predicted gene, 26458

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. VWC2 Increases Bone Formation Through Inhibiting Activin Signaling. Almehmadi A, et al. Calcif Tissue Int, 2018 Dec. PMID 30074079, Free PMC Article
  2. Brorin, a novel secreted bone morphogenetic protein antagonist, promotes neurogenesis in mouse neural precursor cells. Koike N, et al. J Biol Chem, 2007 May 25. PMID 17400546
  3. A novel neural-specific BMP antagonist, Brorin-like, of the Chordin family. Miwa H, et al. FEBS Lett, 2009 Nov 19. PMID 19852960
  4. Reconstruction of phrenic neuron identity in embryonic stem cell-derived motor neurons. Machado CB, et al. Development, 2014 Feb. PMID 24496616, Free PMC Article
  5. High-resolution proteomics unravel architecture and molecular diversity of native AMPA receptor complexes. Schwenk J, et al. Neuron, 2012 May 24. PMID 22632720

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in negative regulation of BMP signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of BMP signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in neurotransmitter receptor localization to postsynaptic specialization membrane IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in neurotransmitter receptor localization to postsynaptic specialization membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of cell-substrate adhesion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of neuron differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of AMPA glutamate receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of AMPA glutamate receptor complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in basement membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular matrix IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in extrinsic component of postsynaptic membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in extrinsic component of postsynaptic membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in interstitial matrix IDA
Inferred from Direct Assay
more info
 PubMed 
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
brorin
Names
CR (chordin-like cysteine-rich) domain-containing adhesive protein
brain-specific chordin-like protein
von Willebrand factor C domain-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_177033.3 → NP_796007.1  brorin precursor

    See identical proteins and their annotated locations for NP_796007.1

    Status: VALIDATED

    Source sequence(s)
    AK141514, AL663071
    Consensus CDS
    CCDS36111.1
    UniProtKB/Swiss-Prot
    B2RQ98, Q5SSH5, Q8C8N3
    Related
    ENSMUSP00000105303.2, ENSMUST00000109681.8
    Conserved Domains (1) summary
    cl17735
    Location:217 → 272
    VWC; von Willebrand factor type C domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    11063836..11219295
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036156760.1 → XP_036012653.1  brorin isoform X1

    UniProtKB/Swiss-Prot
    B2RQ98, Q5SSH5, Q8C8N3
    Related
    ENSMUSP00000128761.2, ENSMUST00000129670.8
    Conserved Domains (1) summary
    cl17735
    Location:217 → 272
    VWC; von Willebrand factor type C domain

RNA

  1. XR_380971.4 RNA Sequence

  2. XR_380970.4 RNA Sequence

  3. XR_001780018.3 RNA Sequence

  4. XR_004936977.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8C8N3.1 GenPept UniProtKB/Swiss-Prot:Q8C8N3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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