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Ism1 isthmin 1, angiogenesis inhibitor [ Mus musculus (house mouse) ]

Gene ID: 319909, updated on 5-Mar-2024

Summary

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Official Symbol
Ism1provided by MGI
Official Full Name
isthmin 1, angiogenesis inhibitorprovided by MGI
Primary source
MGI:MGI:2442963
See related
Ensembl:ENSMUSG00000074766 AllianceGenome:MGI:2442963
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ism; 5430433G21Rik
Summary
Involved in negative regulation of angiogenesis. Predicted to be located in extracellular region. Is expressed in several structures, including brain; eye; immune system; limb long bone; and lung. Orthologous to human ISM1 (isthmin 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in lung adult (RPKM 22.8), adrenal adult (RPKM 12.2) and 9 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 F3; 2 69.06 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (139515169..139600500)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (139673359..139758581)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene ADP/ATP translocase 2 pseudogene Neighboring gene serine palmitoyltransferase, long chain base subunit 3 Neighboring gene STARR-seq mESC enhancer starr_05833 Neighboring gene STARR-seq mESC enhancer starr_05835 Neighboring gene STARR-seq mESC enhancer starr_05836 Neighboring gene STARR-seq mESC enhancer starr_05837 Neighboring gene STARR-seq mESC enhancer starr_05838 Neighboring gene STARR-seq mESC enhancer starr_05839 Neighboring gene taspase, threonine aspartase 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:139750776-139750959 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:139760469-139760763 Neighboring gene STARR-positive B cell enhancer mm9_chr2:139792158-139792459 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:139867947-139868134 Neighboring gene STARR-positive B cell enhancer ABC_E4503 Neighboring gene ribosomal protein S19, pseudogene 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Phosphoproteomic mapping reveals distinct signaling actions and activation of muscle protein synthesis by Isthmin-1. Zhao M, et al. Elife, 2022 Sep 28. PMID 36169399, Free PMC Article
  2. ISM1 suppresses LPS-induced acute lung injury and post-injury lung fibrosis in mice. Nguyen N, et al. Mol Med, 2022 Jun 25. PMID 35752760, Free PMC Article
  3. ISM1 protects lung homeostasis via cell-surface GRP78-mediated alveolar macrophage apoptosis. Lam TYW, et al. Proc Natl Acad Sci U S A, 2022 Jan 25. PMID 35046017, Free PMC Article
  4. Isthmin-1 is an adipokine that promotes glucose uptake and improves glucose tolerance and hepatic steatosis. Jiang Z, et al. Cell Metab, 2021 Sep 7. PMID 34348115, Free PMC Article
  5. Novel HIF-1-target gene isthmin1 contributes to hypoxia-induced hyperpermeability of pulmonary microvascular endothelial cells monolayers. Li J, et al. Am J Physiol Cell Physiol, 2021 Oct 1. PMID 34469202

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The paracrine isthmin1 transcriptionally regulated by C/EBPbeta exacerbates pulmonary vascular leakage in murine sepsis.
    Title: The paracrine isthmin1 transcriptionally regulated by C/EBPβ exacerbates pulmonary vascular leakage in murine sepsis.
  2. Isthmin-1 attenuates allergic Asthma by stimulating adiponectin expression and alveolar macrophage efferocytosis in mice.
    Title: Isthmin-1 attenuates allergic Asthma by stimulating adiponectin expression and alveolar macrophage efferocytosis in mice.
  3. Isthmin-1 (Ism1) modulates renal branching morphogenesis and mesenchyme condensation during early kidney development.
    Title: Isthmin-1 (Ism1) modulates renal branching morphogenesis and mesenchyme condensation during early kidney development.
  4. Phosphoproteomic mapping reveals distinct signaling actions and activation of muscle protein synthesis by Isthmin-1.
    Title: Phosphoproteomic mapping reveals distinct signaling actions and activation of muscle protein synthesis by Isthmin-1.
  5. ISM1 suppresses LPS-induced acute lung injury and post-injury lung fibrosis in mice.
    Title: ISM1 suppresses LPS-induced acute lung injury and post-injury lung fibrosis in mice.
  6. Isthmin-1 is an adipokine that promotes glucose uptake and improves glucose tolerance and hepatic steatosis.
    Title: Isthmin-1 is an adipokine that promotes glucose uptake and improves glucose tolerance and hepatic steatosis.
  7. ISM1 protects lung homeostasis via cell-surface GRP78-mediated alveolar macrophage apoptosis.
    Title: ISM1 protects lung homeostasis via cell-surface GRP78-mediated alveolar macrophage apoptosis.
  8. Novel HIF-1-target gene isthmin1 contributes to hypoxia-induced hyperpermeability of pulmonary microvascular endothelial cells monolayers.
    Title: Novel HIF-1-target gene isthmin1 contributes to hypoxia-induced hyperpermeability of pulmonary microvascular endothelial cells monolayers.
  9. ISM is a novel vascular permeability inducer that functions through cell-surface GRP78-mediated Src activation as well as induction of apoptosis
    Title: Isthmin is a novel vascular permeability inducer that functions through cell-surface GRP78-mediated Src activation.
  10. ISM1 transcripts are found in tissues as the anterior mesendoderm, paraxial and lateral plate mesoderm, MHB and trunk neural tube, as well as in the somites and dermomyotome. In the newborn and adult, ISM1 is prominently expressed in the lung and brain.
    Title: Distinct spatiotemporal expression of ISM1 during mouse and chick development.
Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Clone Names

  • RP23-296P2.1, 5430433G21Rik

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in negative regulation of angiogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of angiogenesis IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
isthmin-1
Names
isthmin 1 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001276489.2 → NP_001263418.1  isthmin-1 precursor

    Status: VALIDATED

    Source sequence(s)
    AL928831
    Consensus CDS
    CCDS50730.2
    UniProtKB/Swiss-Prot
    A2ATD1
    UniProtKB/TrEMBL
    V9GXR4
    Related
    ENSMUSP00000139280.2, ENSMUST00000184404.8
    Conserved Domains (2) summary
    smart00723
    Location:286 → 449
    AMOP; Adhesion-associated domain present in MUC4 and other proteins
    smart00209
    Location:218 → 259
    TSP1; Thrombospondin type 1 repeats

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    139515169..139600500
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036162293.1 → XP_036018186.1  isthmin-1 isoform X2

    Conserved Domains (1) summary
    smart00209
    Location:218 → 259
    TSP1; Thrombospondin type 1 repeats

  2. XM_036162292.1 → XP_036018185.1  isthmin-1 isoform X1

    Conserved Domains (1) summary
    smart00209
    Location:218 → 259
    TSP1; Thrombospondin type 1 repeats

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001126490.1: Suppressed sequence

    Description
    NM_001126490.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A2ATD1.1 GenPept UniProtKB/Swiss-Prot:A2ATD1

Gene LinkOut

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