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Slc17a4 solute carrier family 17 (sodium phosphate), member 4 [ Mus musculus (house mouse) ]

Gene ID: 319848, updated on 11-Apr-2024

Summary

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Official Symbol
Slc17a4provided by MGI
Official Full Name
solute carrier family 17 (sodium phosphate), member 4provided by MGI
Primary source
MGI:MGI:2442850
See related
Ensembl:ENSMUSG00000021336 AllianceGenome:MGI:2442850
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
9130214H05Rik
Summary
Predicted to enable sialic acid transmembrane transporter activity. Predicted to be involved in sialic acid transport. Predicted to act upstream of or within sodium ion transport. Predicted to be located in plasma membrane. Predicted to be active in lysosome. Predicted to be integral component of plasma membrane. Is expressed in several structures, including alimentary system; genitourinary system; and spinal cord mantle layer. Orthologous to human SLC17A4 (solute carrier family 17 member 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver adult (RPKM 15.9), large intestine adult (RPKM 13.0) and 3 other tissues See more
Orthologs
human all
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Genomic context

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See Slc17a4 in Genome Data Viewer
Location:
13 A3.1; 13 9.98 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (24081862..24098992, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (23897879..23915009, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 17 (sodium phosphate), member 3 Neighboring gene solute carrier family 17 (sodium phosphate), member 1 Neighboring gene U1 small nuclear ribonucleoprotein 1C, pseudogene 2 Neighboring gene predicted gene, 33516 Neighboring gene H2B clustered histone 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A Na+-phosphate cotransporter homologue (SLC17A4 protein) is an intestinal organic anion exporter. Togawa N, et al. Am J Physiol Cell Physiol, 2012 Jun 1. PMID 22460716
  2. Histone variants enriched in oocytes enhance reprogramming to induced pluripotent stem cells. Shinagawa T, et al. Cell Stem Cell, 2014 Feb 6. PMID 24506885
  3. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
  4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables symporter activity IEA
Inferred from Electronic Annotation
more info
  
enables thyroid hormone transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables urate transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables urate transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in monoatomic anion transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within sodium ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in sodium-dependent phosphate transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sodium-dependent phosphate transport ISO
Inferred from Sequence Orthology
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in apical plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in brush border membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
probable small intestine urate exporter
Names
putative small intestine sodium-dependent phosphate transport protein
solute carrier family 17 member 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_177016.3 → NP_795990.2  probable small intestine urate exporter

    See identical proteins and their annotated locations for NP_795990.2

    Status: VALIDATED

    Source sequence(s)
    AK033669, AK050272, AK162320
    Consensus CDS
    CCDS49221.1
    UniProtKB/Swiss-Prot
    B9EJP0, Q5NCM1
    Related
    ENSMUSP00000021769.10, ENSMUST00000021769.16
    Conserved Domains (2) summary
    cd06174
    Location:98 → 475
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00894
    Location:27 → 486
    2A0114euk; Na(+)-dependent inorganic phosphate cotransporter

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    24081862..24098992 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006516694.1 → XP_006516757.1  probable small intestine urate exporter isoform X2

    Conserved Domains (1) summary
    cd17318
    Location:37 → 421
    MFS_SLC17; Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters

  2. XM_006516695.1 → XP_006516758.1  probable small intestine urate exporter isoform X3

    Conserved Domains (1) summary
    cd17318
    Location:37 → 418
    MFS_SLC17; Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters

  3. XM_006516693.1 → XP_006516756.1  probable small intestine urate exporter isoform X1

    UniProtKB/TrEMBL
    A0A2C9F2D4
    Related
    ENSMUSP00000106037.4, ENSMUST00000110407.4
    Conserved Domains (1) summary
    cd17318
    Location:37 → 448
    MFS_SLC17; Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters

  4. XM_006516700.3 → XP_006516763.1  probable small intestine urate exporter isoform X5

    Conserved Domains (1) summary
    TIGR00894
    Location:2 → 283
    2A0114euk; Na(+)-dependent inorganic phosphate cotransporter

  5. XM_006516697.3 → XP_006516760.1  probable small intestine urate exporter isoform X4

    See identical proteins and their annotated locations for XP_006516760.1

    Conserved Domains (1) summary
    cl28910
    Location:37 → 370
    MFS; Major Facilitator Superfamily

  6. XM_006516696.1 → XP_006516759.1  probable small intestine urate exporter isoform X4

    See identical proteins and their annotated locations for XP_006516759.1

    Conserved Domains (1) summary
    cl28910
    Location:37 → 370
    MFS; Major Facilitator Superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5NCM1.2 GenPept UniProtKB/Swiss-Prot:Q5NCM1

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