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Nwd2 NACHT and WD repeat domain containing 2 [ Mus musculus (house mouse) ]

Gene ID: 319807, updated on 11-Apr-2024

Summary

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Official Symbol
Nwd2provided by MGI
Official Full Name
NACHT and WD repeat domain containing 2provided by MGI
Primary source
MGI:MGI:1920464
See related
Ensembl:ENSMUSG00000090061 AllianceGenome:MGI:1920464
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hn1-ps2; mKIAA1239; 3110047P20Rik; B830017A01Rik
Summary
Is expressed in nervous system and tongue. Orthologous to human NWD2 (NACHT and WD repeat domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cortex adult (RPKM 2.5), frontal lobe adult (RPKM 2.4) and 6 other tissues See more
Orthologs
human all
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Genomic context

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Location:
5 C3.1; 5 32.8 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (63806446..63967889)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (63649103..63810546)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_13173 Neighboring gene STARR-positive B cell enhancer ABC_E11287 Neighboring gene STARR-seq mESC enhancer starr_13174 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:63249548-63249756 Neighboring gene death domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_13175 Neighboring gene STARR-seq mESC enhancer starr_13176 Neighboring gene STARR-seq mESC enhancer starr_13177 Neighboring gene predicted gene, 30837 Neighboring gene STARR-seq mESC enhancer starr_13178 Neighboring gene NACHT and WD repeat domain containing 2, opposite strand Neighboring gene STARR-seq mESC enhancer starr_13179 Neighboring gene hematological and neurological expressed 1 protein pseudogene Neighboring gene RIKEN cDNA 0610040J01 gene Neighboring gene STARR-positive B cell enhancer ABC_E8053 Neighboring gene STARR-seq mESC enhancer starr_13182 Neighboring gene STARR-seq mESC enhancer starr_13187 Neighboring gene STARR-positive B cell enhancer ABC_E8054 Neighboring gene RELT-like 1 Neighboring gene predicted gene, 25608

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identification and expression profile of novel STAND gene Nwd2 in the mouse central nervous system. Yamada S, et al. Gene Expr Patterns, 2022 Dec. PMID 36341976
  2. Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2002 Oct 31. PMID 12465718
  3. Brn3a and Nurr1 mediate a gene regulatory pathway for habenula development. Quina LA, et al. J Neurosci, 2009 Nov 11. PMID 19906978, Free PMC Article
  4. Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant. Quinlan MA, et al. Front Mol Neurosci, 2020. PMID 32581705, Free PMC Article
  5. Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics. Federspiel JD, et al. Mol Cell Proteomics, 2019 Aug 9. PMID 31040226, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA1239

Gene Ontology Provided by MGI

Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
is_active_in synapse EXP
Inferred from Experiment
more info
 PubMed 
is_active_in synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
NACHT and WD repeat domain-containing protein 2
Names
hematological and neurological expressed 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_177006.3 → NP_795980.2  NACHT and WD repeat domain-containing protein 2

    See identical proteins and their annotated locations for NP_795980.2

    Status: VALIDATED

    Source sequence(s)
    AC114408, AC122744
    Consensus CDS
    CCDS51508.1
    UniProtKB/Swiss-Prot
    Q3UVW7, Q6P5U7, Q8CHA7
    Related
    ENSMUSP00000124712.2, ENSMUST00000159584.3
    Conserved Domains (4) summary
    COG2319
    Location:1092 → 1448
    WD40; WD40 repeat [General function prediction only]
    pfam13191
    Location:394 → 539
    AAA_16; AAA ATPase domain
    sd00039
    Location:1013 → 1063
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:1164 → 1425
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    63806446..63967889
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006503991.5 → XP_006504054.1  NACHT and WD repeat domain-containing protein 2 isoform X2

    Conserved Domains (3) summary
    COG2319
    Location:951 → 1307
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:872 → 922
    7WD40; WD40 repeat [structural motif]
    pfam13191
    Location:253 → 382
    AAA_16; AAA ATPase domain

  2. XM_036165207.1 → XP_036021100.1  NACHT and WD repeat domain-containing protein 2 isoform X1

    Conserved Domains (3) summary
    COG2319
    Location:985 → 1341
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:906 → 956
    7WD40; WD40 repeat [structural motif]
    pfam13191
    Location:287 → 416
    AAA_16; AAA ATPase domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_028470.1: Suppressed sequence

    Description
    NM_028470.1: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6P5U7.2 GenPept UniProtKB/Swiss-Prot:Q6P5U7

Gene LinkOut

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